END STAGE RENAL DISEASE

This study looks at 75 kidney transplant patients to compare two different drug plans that help prevent organ rejection. One group gets a single dose of a drug called RATG, while the other gets seven doses over a week. The goal is to see which plan causes fewer side effects like …

This study compares a new surgical method, called RADAR, to the standard approach for creating a blood vessel connection (fistula) used for dialysis in people with end-stage kidney disease. The new technique involves moving the radial artery to attach it to a nearby vein with les…

This study looks at whether adding a special filter (hemoperfusion) to regular dialysis can better remove waste products from the blood of people with end-stage kidney disease. About 410 adults on maintenance dialysis will be randomly assigned to get either standard dialysis or d…

This study tests a new device called STARgraft-3, a tube used for dialysis in people with end-stage kidney disease. The goal is to see if it stays open longer and resists infection better than standard grafts. About 21 adults will be followed for up to a year to check how well th…

This study looks at whether people with ANCA vasculitis who have reached end-stage kidney disease can safely stop taking immunosuppressive medications. The goal is to see if stopping these drugs lowers the risk of serious infections and other side effects without causing dangerou…

This study tests a new robotic system, the Medtronic Hugo, for urologic surgeries like prostate, bladder, and kidney procedures. About 144 adults will have surgery with the robot to see if it works safely and effectively. The main goal is to see if the surgery can be completed wi…

This study tests a 1-month course of three medicines (isoniazid, rifapentine, and vitamin B6) to treat latent tuberculosis in 25 adults with end-stage kidney disease who are candidates for a kidney transplant. The goal is to see if this shorter treatment is safe and easy to compl…

This study follows 11 kidney transplant patients who previously received an experimental cell therapy (TX200-TR101) designed to help the body accept the new kidney. Researchers will track safety and side effects for up to 15 years after treatment. The goal is to understand long-t…

This study tests whether a drug called nicorandil can reduce the risk of heart attacks, strokes, and other serious heart problems in people with coronary artery disease who are on dialysis. The trial involves 268 participants and compares those taking nicorandil to those not taki…

This study is testing a new device called the aXess graft for people with end-stage kidney disease who need hemodialysis but cannot have a standard fistula. The graft is placed in the arm to provide a reliable access point for dialysis. Researchers are checking how safe the graft…

This study looks at whether giving extra nutrition through a vein during dialysis (called IDPN) helps people with kidney failure maintain muscle mass and improve their quality of life. About 166 adults on long-term dialysis will receive IDPN or standard care. The goal is to see i…

This study tests whether robot-assisted kidney transplant causes fewer serious problems (like bleeding or blood clots) within 30 days compared to standard open surgery. About 106 adults with kidney failure are randomly assigned to one of the two methods. The goal is to see if the…

This study looks at whether a supervised fitness program can help people with a high body mass index (40-44) lose weight so they can become active on the kidney transplant waiting list. Ten adults who are currently listed as inactive due to obesity will follow a six-month exercis…

This study aimed to see if hydroxychloroquine could prevent COVID-19 hospitalizations in adults on dialysis for kidney failure. It was planned as a randomized trial but was withdrawn before any participants were enrolled. No results are available.

This study tests a virtual health platform that provides exercise, nutrition, and psychological support for people on hemodialysis. About 70 adults with end-stage kidney disease will use the platform to improve their walking ability and overall well-being. The goal is to make hea…

This study tests a recovery plan called ERAS in 60 adults getting a kidney from a living donor. The plan includes a pre-surgery drink, Tylenol, gabapentin, a numbing injection during surgery, and early walking. The goal is to see if it lowers pain and the need for strong narcotic…

This study looks at whether a home-based, virtually supervised exercise program can improve physical function in adults waiting for a kidney transplant. About 80 participants will either do the exercise program or receive health education. The main goal is to see if they can stan…

This study uses health records from 17,000 Canadian adults to understand why some people switch from peritoneal dialysis (done at home) to hemodialysis (done in a clinic). Researchers will look at how often this happens, what predicts it, and what happens to patients after the sw…

This study checks if measuring certain substances in urine can tell if a child's kidney transplant is being rejected or damaged. Researchers will collect urine samples from 445 children aged 2-18 who are getting a kidney biopsy. The goal is to see if these urine markers can repla…

This study compares a new, less invasive needle-based method (endo-AVF) with traditional surgery for creating arteriovenous fistulas (AVFs) needed for dialysis. About 21 adults will be randomly assigned to one of the two techniques to see if a larger trial is feasible. The goal i…

This study looks at 25 people getting a kidney transplant from a living donor. Researchers want to see if the amount of protein in urine is linked to blood flow in the kidneys before and after transplant. The goal is to better understand heart risks after transplant.

This study tests a special education program for veterans with advanced chronic kidney disease. The goal is to help them understand their condition and choose the best type of dialysis, especially home dialysis. About 656 veterans will take part to see if this program improves th…

This study looks at 1000 people who had a first arteriovenous fistula (AVF) created for dialysis. Researchers want to know how many are actually being used for dialysis two years later, and why some are not. The goal is to understand what prevents these fistulas from being used.

This study looks at whether people who received a kidney transplant later regret their choice. Researchers will survey 250 patients at one hospital about their feelings and quality of life one year after surgery. The goal is to understand how common regret is and help doctors sup…

This study aims to find the genes that cause certain inherited kidney diseases, such as Focal Segmental Glomerulosclerosis (FSGS) and Nephrotic Syndrome. Researchers will collect saliva and urine samples from up to 2,050 participants, including patients, their family members, and…

This study uses continuous glucose monitors to track blood sugar changes in 40 adults with diabetes and end-stage kidney disease who are on dialysis. Researchers want to see how glucose levels shift during and between dialysis sessions, and whether those patterns relate to fluid …

This study was designed to see if different types of numbing medicine (anesthesia) could help a surgically created blood vessel connection (fistula) work better for dialysis patients. It planned to compare three methods in people with kidney failure needing a new fistula. However…