END STAGE RENAL DISEASE

This study tested whether kidneys from donors with hepatitis C can be safely transplanted into people without the virus. After transplant, recipients took antiviral medication to cure the hepatitis C infection. The goal was to expand the donor pool and reduce wait times for kidne…

This study looked at whether taking vitamin C by mouth can safely lower the amount of erythropoietin (a drug for anemia) needed by people with end-stage kidney disease on regular dialysis. Sixty adults on stable dialysis with low iron levels and moderate anemia took part. Researc…

This study tested a drug called imlifidase in 64 people with very high antibody levels (cPRA ≥99.9%) who were waiting for a kidney transplant. The goal was to see if imlifidase could help them receive a kidney from a deceased donor and improve kidney function after one year compa…

This study tested a drug called imlifidase in 113 highly sensitized kidney patients who had a positive crossmatch against a deceased donor. The drug was given before transplant to reduce the risk of rejection. The main goal was to see how many patients still had a working kidney …

This study tested ways to reduce low blood pressure episodes during dialysis in over 1,400 kidney failure patients. Researchers trained healthcare providers and encouraged patients to be more involved in their care. The goal was to make dialysis sessions safer and more stable.

This study tested a special collagen implant that slowly releases a drug called sirolimus. It was placed around the new blood vessel connection (fistula) during surgery in 136 people with kidney failure who were on dialysis. The goal was to see if the implant helps the fistula ma…

This study looked at whether adjusting the dose of the anti-rejection drug tacrolimus based on a patient's genetic makeup could help achieve better drug levels in the blood after a kidney transplant. About 280 adult kidney transplant recipients took part. Researchers compared sta…

This study tested whether face-to-face nutrition education about potassium could help people on maintenance hemodialysis control their potassium levels. Fifty adult patients with high potassium took part. The goal was to reduce complications and improve quality of life.

This study examined whether adding a monthly blood-cleaning procedure (hemoperfusion) to regular dialysis can reduce the risk of death, especially from heart or brain problems. Researchers reviewed records of 879 adult dialysis patients over 10 years, comparing those who received…

This study tested a device called the Carry Life UF system in 28 adults with end-stage kidney disease who use continuous ambulatory peritoneal dialysis (CAPD). The device adds glucose to the dialysis fluid already in the belly to help remove more fluid during a 5-hour session. Th…

This study gave 25 people with end-stage kidney disease continued access to the HemoCare™ home hemodialysis system to monitor its safety before it could be sold to the public. Participants had already used the system in a previous study and needed a trained care partner to help w…

This study tested a new dialysis filter called ELISIO-HX in 22 adults with kidney failure. The goal was to see if the filter safely removes harmful waste from the blood without lowering important proteins like albumin. Patients used the filter during their regular dialysis sessio…

This study tested an experimental drug called MK-2060 in 506 adults with end-stage kidney disease who need regular dialysis through a special tube (graft) in their arm. The goal was to see if the drug could prevent dangerous blood clots from blocking the graft. Participants recei…

This study tested a special collagen implant that slowly releases sirolimus around a new dialysis fistula (a surgically created blood vessel connection). The goal was to see if it helps the fistula become usable for dialysis sooner and stay working well. The trial involved 269 ad…

This study tested a man-made blood vessel (HAV) against a standard surgically-created one (AVF) for dialysis in 242 adults with kidney failure. The goal was to see which works better and lasts longer for connecting patients to dialysis machines. Results will help doctors choose t…

This study tested a new dialysis filter (Clearum HS) in 20 adults with end-stage kidney disease who were already on dialysis. The goal was to see if the new filter safely removes waste products like urea as well as or better than standard filters. Participants used their usual fi…

This study tested whether teaching good sleep habits and having motivational conversations could help people on hemodialysis sleep better and improve their quality of life. Forty patients took part, and the results suggest these approaches can boost sleep hygiene, sleep quality, …

This study tested whether doing art therapy during hemodialysis sessions can reduce common symptoms like fatigue and discomfort, and improve patients' sense of spiritual well-being. Sixty adults on dialysis took part; half received at least 30 minutes of art therapy per session w…

This study looked at two different nerve blocks to control pain after a kidney transplant. 40 adults who had a kidney transplant received either an erector spinae plane block or a transmuscular quadratus lumborum block. The goal was to see which block provides better pain relief …

This study tested two drug-free methods to help people on dialysis sleep better and feel more comfortable. Sixty patients in Cyprus received either reflexology (a special foot massage) or sleep hygiene education. Both approaches improved sleep and comfort, but reflexology worked …

This study tested if doing hand grip exercises for six weeks helps the arm blood vessel connection (fistula) used for dialysis grow stronger and work better. 34 adults with kidney failure on dialysis were randomly assigned to either do the exercises or receive standard care. The …

This study tested whether a type of counseling called interpersonal psychotherapy could help people on hemodialysis adjust to their illness and feel less depressed. 48 adults on dialysis for at least 6 months took part. For 8 weeks, some received the counseling while others got u…

This study tested an optimized dialysis method using a special membrane and biofeedback software in 18 adults with kidney failure. The goal was to see if it could shorten recovery time after dialysis and improve quality of life. Participants were observed on both standard and opt…

This study tested whether taking a virtual museum tour during dialysis can help reduce common symptoms and anxiety. Sixty adults who had been on hemodialysis for at least one year participated. Patients in the intervention group viewed a virtual museum five times, while the contr…

This study looked at whether a 26-week exercise program can reduce symptoms and improve quality of life for people on long-term hemodialysis. 133 participants were randomly assigned to exercise or usual care. The main goal was to see if exercise lowered symptom burden after 12 we…

This study tested whether trained transplant recipients, called navigators, could help kidney failure patients complete the steps needed to get a kidney transplant. About 167 adults on dialysis took part, with some getting navigator help and others receiving usual care. The goal …

This study looked at whether people on hemodialysis know how to safely disconnect themselves from the dialysis machine during an emergency, like a fire or power outage. Researchers tested 620 patients from multiple countries using a checklist. The goal was to find out if patients…

This early-stage study tested a single injection of MK-2060 in 14 people with advanced chronic kidney disease to check for side effects and how the drug moves through the body. Only the first part was completed; the later parts were not started for reasons unrelated to safety. Th…

This study looked at whether adding an islet transplant after a kidney transplant helps people with type 1 diabetes avoid kidney failure or death. Researchers reviewed data from 327 French patients who received a kidney transplant between 2000 and 2017. They compared those who al…

This study aimed to understand how dialysis patients personally experience and think about their treatment. Researchers asked 26 adults with end-stage kidney failure to rank statements about their care. The goal was to capture their real perspectives, not to test a new treatment.

This study tested a small implant and an ultrasound system to measure blood flow, diameter, and depth in arteriovenous fistulae (connections between an artery and a vein used for dialysis). Twenty adults with kidney disease took part. The goal was to see if the device is safe and…

This study tested a tool called "Best Case/Worst Case" to help older adults with advanced kidney disease talk with their doctors about future care. 407 patients and their doctors took part across ten clinics. The goal was to see if the tool helped more patients receive palliative…

This study tested a decision-making tool for people waiting for a kidney transplant. 100 participants used an online education tool and discussed their options with a doctor. The goal was to see if the tool helps patients feel more prepared and confident when deciding whether to …

This study tested a program to help older adults (65+) with advanced kidney disease and their doctors talk together about dialysis options. The program included training for doctors and coaching for patients to share their values and ask key questions. The goal was to see if the …

This study tested a program called SPIRIT that helps kidney dialysis patients and their families plan for end-of-life care. The program involved two face-to-face sessions to improve communication and decision-making. Researchers enrolled 852 patients and their surrogates from dia…

This study tested a video-based education program called Explore Transplant@Home to help nearly 1,000 patients with chronic kidney disease learn about living kidney donation. The goal was to improve knowledge and informed decision-making, especially for Black, Hispanic, and Asian…

This study tested a program that teaches kidney transplant waitlist patients and their friends or family about kidney disease, transplantation, and live donation. The goal was to help patients find a live donor by having a 'champion' advocate for them. Researchers looked at how w…

This study looked at how kidney doctors (nephrologists) think about choosing the right type of dialysis for patients with kidney failure. Researchers interviewed 25 active nephrologists to understand their beliefs and attitudes. The goal is to find out if doctors' own preferences…

This study tested a new way for doctors to talk about CPR with seriously ill older patients and their families. About 182 patients with conditions like advanced heart failure or cancer took part. The goal was to see if this approach improved how patients and families rated the qu…

This study aimed to find out how often people in Reunion Island start dialysis as an emergency and what social or medical factors lead to that. Researchers followed 233 adult patients beginning dialysis at local centers. The goal was to gather information to improve care and redu…

This study tested whether a video-based education program (KidneyTIME) helps people with kidney failure learn more about getting a kidney from a living donor. Over 400 adults waiting for a kidney transplant were split into two groups: one received the video program plus usual car…