CHRONIC KIDNEY DISEASES

This study tests if a device called the Gemini System can safely lower blood pressure by treating nerves in the kidney and liver. It includes 175 adults with uncontrolled high blood pressure, with or without other health risks like heart or kidney disease. The main goal is to see…

This study tests a special wrap called SelfWrap that is placed around blood vessels during surgery to create a connection for dialysis. The wrap helps the vessels grow strong and work well without extra procedures. About 600 adults with advanced kidney disease who need a new dial…

This study tests whether taking sodium bicarbonate (baking soda) can improve muscle energy and physical endurance in people with chronic kidney disease and metabolic acidosis. About 80 adults with moderate-to-severe kidney disease will take either sodium bicarbonate or a placebo …

This study tests whether a potassium-lowering drug (SZC) can help elderly patients with heart failure and chronic kidney disease safely take higher, more effective doses of standard heart medications (RAASi). High potassium levels often prevent these patients from getting the ful…

This study tests whether a drug called ferric citrate can lower a harmful protein (FGF23) in children aged 6–18 with moderate chronic kidney disease. About 160 kids will take either the drug or a placebo for 12 months. The goal is to see if the drug is safe and helps control kidn…

This study tests a program called NAVIGATE-Kidney for 448 adults with advanced chronic kidney disease. The program helps patients avoid starting dialysis with a temporary catheter, which is linked to worse outcomes. The goal is to improve health equity and patient decision-making…

This study tests whether a specially designed health behavior program can help people with metabolic syndrome and chronic kidney disease reduce their waist size and improve kidney function. Researchers will compare the program to usual care in 160 adults, measuring changes in wai…

This study looks at how long people with advanced chronic kidney disease should take two blood thinners (aspirin plus clopidogrel or prasugrel) after getting a heart stent. About 900 adults with severe kidney disease will be randomly assigned to either a short or long course of d…

This study tests the safety of using donor bone marrow stem cells in 75 adults with chronic kidney disease, including kidney transplant recipients. The stem cells are given through a vein or directly into the kidney arteries. The goal is to see if this approach is safe and tolera…

This study tests a quicker version of a procedure called renal denervation, which uses energy to calm overactive nerves in the kidneys that can raise blood pressure. The goal is to see if the faster method works as well as the standard approach for people with uncontrolled high b…

This study tests whether giving two common drugs, tranexamic acid and desmopressin, before surgery can reduce bleeding in patients with chronic kidney disease or acute kidney injury. About 100 adults having noncardiac surgery will be randomly assigned to receive one or both drugs…

This study tests whether patiromer, a drug that lowers potassium, allows people with moderate-to-severe chronic kidney disease to safely increase their dose of a common blood pressure medication (irbesartan). The goal is to see if this leads to better kidney protection and lower …

This early-stage study tests whether a stem cell infusion from the same donor can allow kidney transplant recipients to safely stop taking immunosuppressive drugs. Ten adults with a well-functioning, HLA-matched kidney transplant will receive a conditioning treatment followed by …

This study tests a program that helps people with high blood pressure, diabetes, or kidney disease manage their health. Participants use a home blood pressure monitor and get support from community health workers and pharmacists via phone or video. The goal is to see if this extr…

This study looks at whether an automated insulin delivery system (the Medtronic 780G) can help adults with diabetes and advanced kidney disease manage their blood sugar better than their usual insulin injections. Participants will use the system for 8 weeks and then switch to the…

This study tests a treatment called REACT (rilparencel) for people with type 2 diabetes and chronic kidney disease. The treatment involves injecting special kidney cells to help slow down kidney damage. About 685 adults aged 30–80 will receive either the cell injection or a sham …

This study tests a new treatment for high blood pressure in people with moderate to severe chronic kidney disease. It uses low-intensity shockwaves applied to the kidneys over three weeks. The goal is to see if this treatment can safely lower blood pressure and improve kidney fun…

This study tests whether a 12-week physical activity program helps teens with chronic kidney disease (CKD) become more active. About 100 teens aged 13-18 with CKD (stages II-V, not on dialysis or with a transplant) will wear a Fitbit to track their activity. The goal is to see if…

This study looks at whether checking blood pressure at home and having a case manager adjust medications can improve blood pressure control for people with chronic kidney disease who live far from clinics. About 146 adults in northern Alberta, Canada, will either use home monitor…

This study tests a program to help people with low income who have chronic health problems like diabetes, heart disease, or lung disease take their medicines correctly after leaving the hospital. The program provides free medicines, delivers them to the bedside and then home, and…

This early-phase study at Mayo Clinic tests whether transplanting a bladder along with a kidney is safe and works well. It includes up to 30 people aged 1 to 60 who have both kidney failure and bladder problems. The goal is to see if the new bladder functions properly and improve…

This study tests whether taking a combination of green propolis extract and royal jelly for two months can lower inflammation and oxidative stress in people with chronic kidney disease or high blood pressure. About 153 participants will be randomly assigned to receive the supplem…

This study tests whether a single dose of equol, a compound made from soy, can improve blood vessel function in postmenopausal women with and without chronic kidney disease (CKD). Researchers will measure changes in artery health over a few hours after taking equol. The goal is t…

This study tests a team-based program to safely reduce or stop unnecessary medications in people with chronic kidney disease. Researchers will enroll 424 patients in Qatar to see if the program lowers the number of risky drugs, reduces daily pill count, and improves quality of li…

This study tests different treatments to slow chronic kidney disease (CKD) so fewer people develop kidney failure. About 1,000 adults with CKD will receive standard care plus one or more experimental agents. The goal is to find the best treatment or combination that preserves kid…

This study looks at whether mindfulness meditation can improve nerve function in people with chronic kidney disease (CKD). It also tests if a gentle nerve stimulation device can boost meditation's effects. About 150 adults with moderate CKD will participate. The goal is to see if…

This study aims to find better ways to treat depression in people with chronic kidney disease (CKD). About 201 adults with advanced CKD and major depression will receive either behavioral activation teletherapy plus a non-SSRI antidepressant, or the antidepressant plus teletherap…

This study tests whether colchicine, an anti-inflammatory drug, can improve heart function in people with chronic kidney disease. Researchers will measure changes in heart muscle strain using ultrasound. The trial involves 20 adults aged 21-80 with moderate to severe kidney disea…

This early-stage study tests whether stem cells from the amniotic sac can help heal painful wounds in people with calciphylaxis, a rare and serious condition linked to chronic kidney disease. Nine adults aged 18-75 will receive the treatment and be monitored for wound healing and…

This study tests a new ultrasound technique called shear wave elastography to help doctors quickly tell whether a patient has acute or chronic kidney disease in the emergency room. Researchers will enroll 800 adults who need a kidney ultrasound. The goal is to see if this painles…

This study tests a new imaging technique called dynamic full-field optical coherence tomography (OCT) to examine kidney tissue samples. The goal is to see if this method can quickly and accurately identify signs of acute kidney injury or chronic kidney disease, compared to the us…

This study looks at whether a simple home-based walking program can boost memory, thinking skills, and brain structure in older adults (over 55) who have both chronic kidney disease and mild cognitive impairment. Over 6 months, participants will either walk regularly or receive h…

This study tests whether a mobile phone app can help people with kidney problems better control body swelling by guiding daily adjustments to their water pill (diuretic) dose. About 30 participants will use the app for 90 days, entering their weight and blood pressure daily. The …

This study looks at whether taking beetroot extract along with a supervised exercise program can reduce inflammation and oxidative stress, and improve physical function and quality of life in people with chronic kidney disease. About 25 adults with moderate kidney disease (stages…

This study tests a medicine called difelikefalin in teenagers aged 12 to 17 who are on hemodialysis and have moderate to severe itching. The goal is to see if the drug is safe and how much gets into the blood. About 18 teens will receive the medicine up to 4 times a week for 12 w…

This study tests whether a small device that stimulates a nerve in the ear (taVNS) is safe and tolerable for people with chronic kidney disease (stages 3-5) who have autonomic nervous system dysfunction. Thirty participants will use the device daily for two weeks. The goal is to …

This study tests whether a 12-week high-velocity resistance training program is safe and doable for 30 older adults with advanced chronic kidney disease. Participants will either do the strength exercises or attend weekly healthy lifestyle group sessions. The goal is to see if th…

This study looks at how chronic kidney disease affects the immune system, specifically T cells. Researchers will analyze blood samples from 100 patients to understand immune weakness and test a new lab technique to restore T-cell function. The goal is to gather knowledge that cou…

This study is for people who received a kidney transplant and have reduced kidney function. It aims to understand how the drug dapagliflozin affects the structure and blood flow of the transplanted kidney. About 48 participants will be randomly assigned to take dapagliflozin or n…

This study follows 200 adults with advanced chronic kidney disease as they start dialysis, comparing those who choose home dialysis with those who go to a clinic. Researchers will track quality of life, frailty, fatigue, and mood through questionnaires and simple physical tests e…

This study is looking at 300 people with type 2 diabetes who have high levels of protein in their urine, a sign of kidney trouble. Researchers will take small samples of kidney tissue (biopsies) and analyze blood, urine, and stool to find patterns that could improve diagnosis and…

This study looks at how social needs—like food, housing, or safety—affect the health and self-care of African American adults with both type 2 diabetes and chronic kidney disease. Researchers will talk with 330 participants to understand what helps or hinders their care. The goal…

This study tests easier methods to measure how well the kidneys can handle extra work (kidney reserve). It involves 44 adults with sickle cell kidney disease or who have donated a kidney. Participants take a protein drink, and researchers check changes in a blood test called eGFR…

This study looks at why some people with chronic kidney disease (CKD) lose muscle mass and strength, a condition called sarcopenia. Researchers will follow 1,000 adults with CKD to find risk factors for sarcopenia and see if it leads to worse health outcomes like faster kidney de…

This study aims to find out how common chronic kidney disease (CKD) is in semi-rural Sub-Saharan Africa and what factors increase the risk. Researchers will follow 1,200 adults for one year, measuring kidney function and looking at conditions like diabetes, high blood pressure, a…

This study will enroll 5,000 adults with kidney disease or at risk for it, including transplant recipients. Researchers will analyze blood and urine samples to find molecular patterns that predict disease progression, complications, or treatment response. The goal is to improve r…

This study is testing a smartphone app designed to help older adults (55+) with conditions like heart failure, diabetes, and kidney disease manage their health after leaving the hospital. The app provides fall prevention tips, a personalized care plan, and a way to track symptoms…

This study aims to learn why American Indians are at high risk for chronic kidney disease and heart disease. Researchers will follow 500 participants over time, measuring kidney function and tracking heart problems. The goal is to identify key risk factors to improve prevention a…

This study compares two programs designed to help people aged 75 and older with advanced kidney disease decide on their treatment. One program provides standard kidney education, while the other offers personalized decision support. Researchers will see which program helps patien…

This early-stage study looks at whether it's possible to run a larger trial of empagliflozin, a diabetes drug, in 40 children with chronic kidney disease. Participants are randomly assigned to take the drug or continue usual care for 3 months. Researchers will check if the drug i…

This study looks at how blood pressure and artery stiffness change between day and night in people at increased risk for heart disease, including those with kidney problems. Researchers will monitor 120 participants over 24 hours to understand who lacks the healthy nighttime bloo…

This study looks at how dapagliflozin, a diabetes drug, affects heart function and metabolism in people with chronic kidney disease. Researchers will measure heart strain, exercise capacity, and blood markers in 60 adults. The goal is to understand how this drug helps the heart i…

This study is testing a new blood test that uses tiny molecules called microRNA to diagnose bone disease in people with chronic kidney disease. The goal is to find a simple, accurate way to guide treatment without needing a painful bone biopsy. About 40 adults with kidney disease…

This study aims to better understand acute kidney injury and chronic kidney disease by analyzing kidney tissue from 1000 volunteers. Researchers will use advanced technology to identify different disease types and find new targets for therapies. The goal is to pave the way for pe…

This study looks at how common sleep apnea is in people with chronic kidney disease and whether it makes kidney function worse over time. Researchers will follow 356 adults with moderate kidney disease for several years, tracking their health and sleep patterns. The goal is to fi…

This study looks at whether treating suddenly ill adults at home can be a safe and cost-effective alternative to hospital care. Researchers will enroll 3,000 adults with conditions like infections, heart failure, or COPD who live near the hospital. The goal is to compare costs, s…

This study will screen 3,000 adults at a large hospital to find out how many have chronic kidney disease—especially those who don't know it yet. Participants must be over 50, or over 18 with conditions like diabetes or high blood pressure. The goal is to measure how common undiag…

This study watches 1000 people getting a new heart valve (TAVI) to see how it changes their kidneys' reaction to contrast dye. It looks at whether fixing the valve lowers the risk of kidney injury from the dye. The goal is to learn, not to test a new treatment.

This study looks at how the sedative remimazolam behaves in the body of 30 adults receiving a kidney transplant. Researchers will measure drug levels in the blood and monitor sedation depth to ensure safe and predictable anesthesia. The goal is to gather information for better se…

This study is for adults with chronic kidney disease who either have or are at risk for calciphylaxis, a rare and life-threatening condition where blood vessels in the skin harden. Researchers will compare these patients to similar kidney patients without calciphylaxis to learn w…

This study follows 300 preterm and full-term infants from birth to age 10 to understand how early kidney size and function relate to future heart and kidney disease. Researchers use ultrasound and blood/urine tests to find early warning signs. The goal is to identify at-risk chil…

This study looks at how chronic kidney disease (CKD) affects the eyes, brain, and kidneys together. Researchers will use non-invasive MRI scans and eye imaging to see if changes in the brain and retina are linked to memory problems and kidney function. About 1500 adults with CKD …