CHRONIC KIDNEY DISEASES

This study tests whether starting four approved kidney medicines within 8 weeks is safe and works better than the usual slow approach for people with type 2 diabetes and chronic kidney disease. About 64 adults will be randomly assigned to either the rapid start or standard care, …

This study looks at whether doing handgrip exercises at home for 8 weeks can help lower blood pressure in people with chronic kidney disease (CKD). Researchers will also study why blood pressure rises, such as from stress hormones or stiff blood vessels. The study involves 50 adu…

This study tests whether empagliflozin, a diabetes medicine, can reduce protein leakage in urine and help protect the kidneys in people with very advanced chronic kidney disease (eGFR between 10 and 20). About 34 adults with type 2 diabetes will take either empagliflozin or a pla…

This study tests whether a fruit called jaboticaba can help people with chronic kidney disease by reducing inflammation and oxidative stress, and improving gut health. Researchers will give the fruit to 30 adults with kidney disease and measure changes in blood and stool samples.…

This study tests whether sending tailored reminders to doctors can increase the use of recommended medications for chronic kidney disease (CKD). About 1,000 adults with CKD will be included, and doctors will receive alerts through their computer system. The goal is to see if thes…

This study tests if the drug finerenone can prevent chronic kidney disease in adults with liver cirrhosis caused by fatty liver disease (MASLD) who also have fluid buildup in the belly (ascites). About 160 participants will receive either finerenone or spironolactone, along with …

This study tests a new drug, QRX3, in 3,000 adults with chronic kidney disease (CKD) to see if it can slow down kidney function loss. Participants must have declining kidney function but not too rapid. The goal is to improve quality of life and delay the need for dialysis, not to…

This study looks at whether oral semaglutide, a drug already used for diabetes, can slow kidney disease in people who also have fatty liver disease. About 90 adults with both conditions will receive either the drug or standard care for 2 years. Researchers will track kidney funct…

This study checks if a new handheld device can accurately measure creatinine levels from a fingerstick at home, compared to standard lab tests. About 200 adults with kidney disease will use the device themselves and answer a questionnaire about how easy it is to use. The goal is …

This study tests whether a health literacy program can help older adults who take five or more medications daily prevent chronic kidney disease. About 104 participants aged 55-74 will either join the program or receive standard care. The program teaches better medication manageme…

This study looks at whether doing virtual reality exercise during dialysis can help balance important minerals like sodium and potassium in people with end-stage kidney disease. About 40 adults on regular dialysis will try this approach. The goal is to see if it improves their el…

This study looks at a natural chemical called kynurenine in the blood of pregnant women. Some women have chronic kidney disease, which raises their risk of a dangerous pregnancy complication called preeclampsia. Researchers want to see if kynurenine levels differ between women wi…

This study will develop and test new MRI methods to examine the kidneys and brain in people with chronic kidney disease, kidney transplants, or on dialysis. Researchers hope to find better ways to diagnose and track kidney problems and understand why kidney disease often leads to…

This study looks at how a new drug called HRS-1780, being developed for chronic kidney disease, is absorbed, broken down, and removed from the body. Six healthy adult men will take a single dose with a radioactive tracer so scientists can track it in blood, urine, and stool. The …

This study looks at whether gum disease (periodontitis) and chronic kidney disease are connected through bacteria in the mouth and gut. Researchers will study 80 adults aged 18 to 75, some with one or both conditions and some healthy. They will collect mouth and stool samples to …

This study tests whether educational videos and text messages can help people with kidney failure learn about and pursue living-donor transplants. About 430 adults waiting for a kidney will be randomly assigned to get the digital tools with or without a human guide. Researchers w…