CHRONIC KIDNEY DISEASES

This study looked at whether taking a prebiotic supplement (resistant starch) and doing moderate aerobic exercise for 16 weeks could reduce inflammation and improve blood vessel health, thinking, and mood in people with stage 3-4 chronic kidney disease. 68 adults aged 30-75 who w…

This study tested whether dapagliflozin, a diabetes drug, can reduce protein in the urine and protect kidney function in 55 people who had a kidney transplant and have chronic kidney disease. Participants took the drug for 6 months, and researchers measured changes in urine prote…

This study tested whether people with type 2 diabetes and kidney damage can safely participate in a clinical trial from home. Twelve participants took the drug empagliflozin, and depending on their response, some added or switched to finerenone. The goal was to see if remote data…

This study tested a personalized lifestyle program for 120 adults with early-stage chronic kidney disease (CKD). Participants received tailored advice on diet, exercise, and kidney health knowledge over 30 months. The goal was to see if this program could improve kidney function,…

This study looked at whether special programs can help people with chronic kidney disease get kidney transplants earlier and reduce racial differences in care. Over 1,100 adults with advanced kidney disease took part. The programs included a system to identify patients who might …

This study looked at whether giving hospital-level care to acutely ill adults in their own rural homes is a good option. 160 adults with conditions like infections, heart failure, or COPD took part. The goal was to see if this approach could lower costs and help people recover at…

This study tested an experimental cell therapy called REACT (rilparencel) in 53 adults with type 1 or 2 diabetes and chronic kidney disease. The therapy involves injecting a person's own kidney cells into their kidneys to see if it can slow the loss of kidney function. The goal i…

This study tested whether an educational worksheet plus health coaching could help people with chronic kidney disease and high blood pressure lower their blood pressure. 320 participants with moderate to severe kidney disease were split into two groups to compare the effects. The…

This study looked at 108 people with early chronic kidney disease, high blood pressure, and a condition called metabolic acidosis (too much acid in the blood). Researchers compared eating more fruits and vegetables versus taking sodium bicarbonate (baking soda) pills to see if ei…

This study tested an experimental drug called KBP-5074 in 162 adults with moderate-to-severe chronic kidney disease and high blood pressure that wasn't controlled by other medications. The goal was to see if the drug could safely lower blood pressure and reduce kidney damage over…

This study tested a drug called Ziltivekimab in 264 people with advanced chronic kidney disease and high inflammation. The goal was to see if the drug could lower inflammation markers and find the best dose for a future heart study. Participants received monthly injections of eit…

This study tested a digital program called DDEP that helps people with chronic kidney disease and their care partners adopt healthier habits. Over 200 pairs participated, with one group receiving the digital program plus usual care and the other only usual care. The goal was to s…

This study tested whether baricitinib, a drug used for rheumatoid arthritis, can safely reduce protein in the urine of African American adults with APOL1 gene-related kidney disease. Eight participants took the drug for 12 weeks. The goal was to see if it lowers kidney damage mar…

This study tested a drug called TOUR006 in 143 adults with chronic kidney disease and high levels of a protein linked to inflammation (hs-CRP). The goal was to see if monthly or quarterly shots could safely lower inflammation. The study is complete, and results will show if the d…

This study tested whether a drug called Lokelma (SZC) can help people with both chronic kidney disease and heart failure safely reach the highest recommended doses of their heart medications (RAAS inhibitors). These medications are often avoided because they can cause dangerously…

This study tested a new dialysis filter called ELISIO-HX in 22 adults with kidney failure. The goal was to see if the filter safely removes harmful waste from the blood without lowering important proteins like albumin. Patients used the filter during their regular dialysis sessio…

This study tested whether a low-dose blood thinner called rivaroxaban could reduce the risk of major heart problems like heart attack or stroke in people with advanced chronic kidney disease or kidney failure on dialysis. About 1,753 participants were randomly assigned to receive…

This study tested a new device (everlinQ System) to create a connection between an artery and vein in the arm for dialysis in 32 adults with kidney failure. The goal was to see if the connection matured properly and was safe to use for dialysis. The approach is a less invasive wa…

This study tested a new device that creates a blood vessel connection (fistula) for dialysis without major surgery. It involved 24 adults with kidney failure who needed dialysis. The goal was to see if the procedure could be done safely and successfully, and if the connection sta…

This study looked at whether community health workers (CHWs) can improve health outcomes for people with chronic conditions like diabetes, high blood pressure, and obesity. Over 10 months, 202 low-income adults from specific zip codes received either CHW support plus standard car…

This small pilot study tested a cognitive behavioral program to help reduce fatigue in people with chronic kidney disease. Five adults with moderate-to-severe kidney disease took part in remote sessions. The goal was to see if the program was acceptable and to gather data for a l…

This study tested whether adding empagliflozin (a diabetes drug) to standard water pills helps people with acute heart failure and moderate-to-advanced kidney disease urinate out more excess fluid. 25 adults participated, and researchers compared urine output with and without the…

This early-stage study tested a new drug called DISC-0974 in 55 adults with chronic kidney disease (not on dialysis) who also have anemia. The main goal was to check the drug's safety and how the body processes it. Researchers measured side effects, vital signs, and lab results t…

This study tested a 12-week online program combining gentle movement, breathing exercises, and coping skills for adults with chronic physical conditions like heart failure, liver disease, or cancer. The goal was to reduce anxiety and depression. 825 participants completed surveys…

This study analyzed medical records from nearly 920,000 Canadian adults to see how the COVID-19 pandemic affected primary care for chronic conditions like diabetes, heart failure, and depression. Researchers looked at changes in doctor visits, tests, and treatments before and dur…

This study looked at 319 patients with severe acute kidney injury who needed dialysis. The goal was to create a scoring system to predict which patients would develop long-term kidney disease and would benefit from seeing a kidney specialist. Researchers also looked for new risk …

This study looked at whether a computer program could predict when patients being treated at home might deteriorate. Researchers used data from 526 patients in a home hospital program to train and test the machine learning model. The goal was to see if the program could accuratel…

This study looked at data from 372 patients to see if a computer program could predict who would need to be readmitted to the hospital within 30 days. Researchers used information like age and health history to train the computer model. The goal was to find patterns that could he…

This study looked at how sex hormones, especially estrogen, affect blood vessel function in women with chronic kidney disease (CKD). Researchers compared pre- and post-menopausal women with CKD to healthy women of similar ages. The goal was to understand why women with CKD have h…

This study tested a program that helps low-income African Americans with diabetic kidney disease get their basic needs met, like food and housing. 50 people took part to see if this kind of help is practical and can improve their health. The goal was to learn if addressing life c…

This study tested an electronic alert system that reminds doctors to screen, monitor, and refer patients with chronic kidney disease (CKD). It involved 66 primary care centers in Stockholm, covering about 780,000 people. The goal was to see if the system improves detection and ma…

This study tested whether 3D ultrasound can accurately measure kidney and tumor volumes compared to standard CT or MRI scans. 53 adults with chronic kidney disease or kidney tumors participated. Researchers compared 3D ultrasound measurements to those from contrast-enhanced CT or…

This study looked at 76 adults with end-stage kidney disease to see if special ultrasound tests could predict whether their dialysis access (a connection called an arteriovenous fistula) would work well. The researchers measured artery stiffness and blood vessel function before a…

This study used advanced MRI scans to look at the hearts of 276 people with chronic kidney disease, including those on dialysis. The goal was to identify different types of heart damage and see which patterns lead to worse outcomes. The research did not test a new treatment but a…

This study reviewed medical records of 345 adults to see if primary care doctors referred patients with chronic kidney disease to a kidney specialist at the right time and with the right treatment. The goal was to understand how well current referral practices work, not to test a…

This study tested whether sending digital letters to patients with chronic kidney disease and their family doctors could increase the use of recommended medications. Over 28,000 adults in Denmark took part. The goal was to see if simple reminders through the official government e…

This study looked at whether training community health workers to focus on kidney disease care, and teaching doctors about trauma-informed care, could improve quality of life for Black and Hispanic patients with advanced chronic kidney disease. The study involved 153 patients fro…

This study looked at how dapagliflozin, a drug already used for kidney protection, changes the gut bacteria in people with chronic kidney disease who do not have diabetes. Researchers measured gut bacteria diversity and related waste products in the blood before and after 12 week…

This study tested a program to help older adults (65+) with advanced kidney disease and their doctors talk together about dialysis options. The program included training for doctors and coaching for patients to share their values and ask key questions. The goal was to see if the …

This study looked back at medical records of 490 patients with liver cirrhosis and a type of kidney failure called hepatorenal syndrome. Researchers compared how well patients with and without chronic kidney disease responded to standard treatment with terlipressin and albumin. T…

This study looked at whether certain gene variants (APOL1) are linked to advanced chronic kidney disease (stage 4) in Afro-Caribbean adults living in Guadeloupe. Researchers analyzed blood samples from 88 participants to find how common these gene variants are. The goal was to be…

This study tested whether using a more accurate blood pressure reading (central aortic pressure) instead of the standard arm cuff helps manage hypertension in people with advanced chronic kidney disease. 116 participants were randomly assigned to either the new method or usual ca…

This study tested ways to improve kidney disease screening and treatment for Hispanic and Black patients with diabetes. Researchers worked with community groups to screen people and helped clinics provide better care. The goal was to slow kidney disease in these groups and gather…

This study tested whether an electronic alert in the medical record system could prompt doctors to order a simple urine test (UACR) for patients with type 2 diabetes who hadn't had one in the past year. The goal was to catch chronic kidney disease earlier, when treatments can mak…

This study tested whether a video-based education program (KidneyTIME) helps people with kidney failure learn more about getting a kidney from a living donor. Over 400 adults waiting for a kidney transplant were split into two groups: one received the video program plus usual car…

This study asked 140 people in the UK—including patients with early chronic kidney disease, their families, and healthcare professionals—what they think are the most important goals for managing the condition on their own. Through a series of surveys, the team identified top prio…