ATOPIC DERMATITIS

This study tested whether adding an investigational drug called rocatinlimab to standard eczema creams works better than using the creams alone. It involved 746 adults with moderate-to-severe atopic dermatitis (eczema) whose skin didn't respond well enough to strong prescription …

This study tested the safety and effectiveness of a drug called lebrikizumab for adults and adolescents with moderate-to-severe atopic dermatitis (eczema) who had previously been treated with dupilumab. The 86 participants received lebrikizumab injections to see if it could signi…

This small study tested whether getting a measles vaccine could improve symptoms of moderate-to-severe eczema in adults. Researchers gave 20 adult participants either the real measles vaccine or a placebo shot. They then monitored changes in the participants' immune systems and e…

This study tested a new drug called UCB1381 to see if it is safe and if it can help control moderate to severe eczema (atopic dermatitis). First, healthy volunteers received single doses to check for safety. Then, people with eczema received multiple doses over time to see if the…

This study tested a new topical cream called tapinarof for people with moderate to severe eczema (atopic dermatitis). Over 400 children and adults applied the cream or a placebo once daily for 8 weeks to see if it could clear or nearly clear their skin and reduce itching. The goa…

This study tested a new ointment called LNK01004 for adults with moderate to severe atopic dermatitis, also known as eczema. About 75 participants applied one of two strengths of the ointment or a placebo cream twice daily for 8 weeks. The main goal was to see how well it reduced…

This was a first-step safety study for a new injectable drug called BSI-045B, intended to treat atopic dermatitis (eczema). Researchers tested single and multiple doses in 54 healthy volunteers and a small group of patients with moderate-to-severe eczema to see how safe and toler…

This study compared two oral medications, baricitinib and azathioprine, when used alongside standard steroid creams for adults with moderate-to-severe eczema. The goal was to see which drug combination was more effective and safer at reducing skin inflammation and itch over 12 we…

This study tested the safety and how much of a new topical cream called tapinarof gets into the body when used by children with widespread atopic dermatitis (eczema). 36 children aged 2 to 17 applied the cream daily for 4 weeks. The main goal was to check for side effects and mea…

This study tested whether a moisturizer containing postbiotics (substances from 'friendly' bacteria and yeast) could help prevent eczema from coming back in children aged 0-6 years. It compared this special lotion to stopping moisturizer use entirely after getting the eczema unde…

This study tested a new topical cream called PRN473 for adults with mild to moderate eczema. In 39 participants, researchers applied the cream to one skin patch and a placebo cream to another to compare safety and early signs of effectiveness. The main goal was to see if the trea…

This study tested a new drug called camoteskimab for adults with moderate to severe eczema (atopic dermatitis). For the first 16 weeks, some participants received the drug and others received a placebo, then everyone received the drug. The main goal was to see if the drug safely …

This study tested a new ointment called YR001 for adults with mild to moderate eczema (atopic dermatitis). The main goal was to check how safe and well-tolerated the ointment is when applied to the skin. Researchers also looked at whether it helped improve eczema symptoms and how…

This study tested lebrikizumab, an injectable medication, for long-term safety and effectiveness in people with moderate-to-severe eczema (atopic dermatitis). Over 1,100 participants who had previously been in lebrikizumab studies continued treatment for up to 33 months. The rese…

This study tested whether a new drug called rocatinlimab can help adults with moderate-to-severe eczema when other creams haven't worked well enough. 769 participants were randomly assigned to receive either the drug or a placebo injection for 24 weeks. Researchers measured how m…

This large, completed study tested whether a daily oral medication called upadacitinib could safely reduce the skin rash and severe itching of moderate to severe eczema. It involved over 900 participants, including teenagers and adults, who were candidates for systemic therapy. T…

This study tested an injectable drug called lebrikizumab in 90 teens and adults with moderate-to-severe atopic dermatitis (eczema) who have skin of color. The main goal was to see how safe the drug is and how well it works to clear skin and reduce severe itching over 24 weeks. Re…

This study tested whether methotrexate works as well as cyclosporine for adults with moderate-to-severe eczema (atopic dermatitis). Both drugs aim to control the disease, but cyclosporine carries risks like high blood pressure and kidney problems. Researchers enrolled 100 patient…

This study tested a new drug called UCB9741 to see if it is safe and if it can help control moderate-to-severe atopic dermatitis (eczema). First, healthy volunteers received single doses to check safety. Then, people with eczema received repeated doses to see if their skin condit…

This study tested an injectable drug called dupilumab, given with a standard steroid cream, in 62 Japanese children and teenagers (aged 6 months to 18 years) with moderate-to-severe eczema that wasn't well-controlled by their usual treatments. The main goal was to see if the drug…

This study tested whether a daily oral medication called upadacitinib could safely and effectively treat moderate to severe eczema (atopic dermatitis). It involved over 900 teens and adults whose eczema was not well-controlled with creams. The main goal was to see if the pill cou…

This study tested whether a daily probiotic supplement could help control eczema in children aged 3 months to 3 years. One hundred children with eczema were given either the probiotic or a placebo for three months. Researchers measured changes in their skin condition, quality of …

This completed Phase 3 trial tested whether adding traditional Chinese herbal medicine to standard care helps control moderate-to-severe eczema (atopic dermatitis). The study involved 19 participants aged 6-30 and measured changes in skin symptoms and quality of life over 14 week…

This study looked at whether the medication dupilumab helps repair the skin's protective barrier in people with moderate-to-severe eczema. It involved 44 Chinese patients who received dupilumab for 16 weeks. Researchers measured how well the skin held moisture before and after ge…

This study tested an injectable medication called rocatinlimab for teenagers with moderate-to-severe eczema (atopic dermatitis). Over 500 participants received either the drug or a placebo for 52 weeks to see how well it cleared skin and reduced itching. The main goal was to see …

This study tested whether a cream containing ruxolitinib could help adults with moderate atopic dermatitis (eczema) who had not gotten enough relief from common prescription creams like corticosteroids. The trial involved 241 participants and compared the active cream to a placeb…

This early-stage study tested the safety and initial effectiveness of an oral medication called soquelitinib for adults with moderate-to-severe atopic dermatitis (eczema) who haven't responded well to other treatments. Researchers gave different doses to 82 participants, comparin…

This study tested whether managing eczema through an online team of doctors works as well as traditional in-person visits. 300 patients with eczema were randomly assigned to either use the online system or continue with regular office appointments for one year. Researchers compar…

This early-stage study tested a new oral medication called KT-621 for adults with moderate to severe eczema. The main goals were to check if the pill was safe and how the body processed it. Researchers enrolled 22 participants to take the drug and monitored them closely for side …

This study tested an experimental drug called ATI-2138 in 14 adults with moderate to severe atopic dermatitis (eczema) for 12 weeks. Researchers wanted to see if the drug was safe and if it could reduce skin inflammation and itching. The study measured changes in skin severity, i…

This study tested a new injectable medication called BSI-045B for adults with moderate to severe atopic dermatitis (eczema). Twenty-two participants received injections weekly for a month, then every two weeks for about six months. Researchers measured how much the treatment redu…

This study tested a new injectable medication called rocatinlimab in teenagers with moderate-to-severe eczema (atopic dermatitis). The main goal was to check how safe and well-tolerated the treatment was over one year. It involved 187 adolescents whose eczema was not well-control…

This completed study tested four different doses of an experimental drug called LEO 138559 (temtokibart) against a placebo in 262 adults with moderate-to-severe atopic dermatitis (eczema). The goal was to find the most effective and safest dose to reduce the severity and extent o…

This study observed how safe and effective the approved eczema medication upadacitinib was for teenagers in Japan during routine medical care. It followed about 170 adolescents, aged 12 to 18, who were prescribed the drug by their doctors for up to two years. The goal was to gath…

This study tested an investigational injectable drug called CM310 for teenagers with moderate-to-severe eczema. The main goal was to see if the drug could significantly clear skin and reduce itching compared to a placebo. It was a large, late-stage trial involving 180 participant…

This study tested an investigational drug called AK120 in adults with moderate to severe atopic dermatitis (eczema). The main goal was to see if the drug safely reduces the severity and extent of the skin rash. About 450 participants received the treatment and were followed for a…

This first-in-human study tested a new drug called CM512 to see if it is safe for people. It involved both healthy volunteers and patients with moderate to severe eczema. The main goal was to check for side effects and see how the drug moves through the body at different doses.

This completed Phase 3 trial tested whether tralokinumab injections every two weeks could safely and effectively treat moderate-to-severe atopic hand eczema. The study involved 235 adults whose hand eczema did not improve enough with standard creams and who also had eczema elsewh…

This study tested a once-daily cream called tapinarof for people with moderate to severe eczema. Over 400 children and adults used the cream or a placebo for 8 weeks to see if it could clear or nearly clear their skin. The main goal was to see if the active cream was more effecti…

This study checked if a new eczema medication called rocatinlimab affects how well vaccines work. Researchers compared 221 adults with moderate-to-severe eczema who received either the drug or a placebo. They measured participants' immune responses to tetanus and meningococcal va…

This study tested whether a treatment called STMC-103H, which contains live bacteria, could prevent babies from developing eczema and other allergies. It involved 283 newborns and infants who had a family history of allergies. The main goal was to see if the treatment was safe an…

This study tested whether adding a short psychological therapy (called EMD-U) to usual care could improve life quality for adults with eczema or prurigo nodularis who have severe scratching problems. The therapy combines techniques from different talk therapies to help reduce the…

This study observed how well an approved drug, upadacitinib, works for people in Japan with a severe form of atopic dermatitis that causes intensely itchy, painful skin bumps called prurigo nodularis. About 200 participants took the oral medication daily for 48 weeks as part of t…

This study tested whether an existing eczema medication, dupilumab, could improve sleep quality for adults with moderate-to-severe atopic dermatitis. It involved 188 participants who received either the drug or a placebo for 12 weeks, with researchers tracking sleep quality, itch…

This study aimed to understand how easy it was for parents to use a special online platform. The platform let parents track their infant's gut bacteria and eating habits over time. It involved parents of both healthy babies and babies with early eczema. The main goal was to see i…

This was an early-stage study to check the safety of a new injection called 9MW1911 in healthy people. The main goal was to see how well the body tolerated the drug and to find the highest safe dose. Researchers also measured how long the drug stayed in the body and if it trigger…

This study is checking on children years after their mothers took part in a trial of a special nutritional drink before and during pregnancy. Researchers want to see if that early nutrition affects the children's growth, weight, thinking skills, metabolism, and overall health. Th…

This was a small, completed lab study that tested whether specially engineered versions of a natural immune protein (called IL-2 muteins) could selectively boost a type of calming immune cell (regulatory T cells) taken from patients with various autoimmune and inflammatory diseas…

This study aimed to understand how the approved eczema medication dupilumab changes the immune environment and gene activity in the skin over time. Seventeen adults with moderate-to-severe eczema received dupilumab injections for a year. Researchers took small skin samples to ana…

This study aimed to understand if specific fungi on the skin are linked to atopic dermatitis (eczema), especially on the head and neck. Researchers compared skin and blood samples from 30 adults with eczema to 15 healthy adults. The goal was to map the skin's fungal community and…

This study aimed to understand how the approved eczema medication dupilumab affects the skin's barrier function. It involved 52 patients with moderate to severe atopic dermatitis who received dupilumab, plus some healthy volunteers for comparison. Researchers used a special tape-…

This early-stage study tested a single dose of an experimental drug called rocatinlimab in 20 healthy Chinese adults. The main goal was to see how the drug moves through the body and to check for any immediate side effects. This information helps researchers understand the drug's…

This study tested a new method using tiny needles to collect fluid from just under the skin. It involved 20 people, both healthy volunteers and those with atopic dermatitis (eczema). The goal was to see if this method works well and is comfortable, to help researchers better unde…

This early study tested how a potential eczema medicine moves through the body when made in different forms (fast-release vs. slow-release pills). Researchers gave 12 healthy adults five different versions of the pill, some with food and some without, to see which formula is abso…

This study aimed to understand if key nutrients in a mother's body during pregnancy, like folate and vitamin D, are connected to whether her baby develops atopic dermatitis (eczema) in the first 6 months of life. Researchers followed 487 pregnant women in Shanghai, checking their…

This small, early-stage study aimed to understand how a new drug for moderate-to-severe eczema (rocatinlimab) might change how the body processes other common medications. It involved 21 adults with eczema to measure drug levels in the blood when taken alone and together. The mai…

This study aimed to see if a new auto-injector pen delivers a drug for atopic dermatitis (eczema) as effectively as the standard vial and syringe method. It involved 231 healthy adults who received a single dose. Researchers measured the drug levels in the blood and monitored for…

This small study aimed to understand if and how the common skin bacteria Staphylococcus aureus (staph) triggers inflammation in people with eczema (atopic dermatitis). Researchers applied patches containing staph bacteria, its proteins, and a harmless skin bacteria to the skin of…

This study aimed to understand the different genetic patterns, or 'endotypes,' in the skin of people with mild versus moderate-to-severe eczema (atopic dermatitis). Researchers collected skin samples from 433 participants, including people with eczema and those without, over mult…

This study aimed to see if a potential eczema medication, rocatinlimab, is absorbed the same way by the body when given from a traditional glass vial versus a newer, ready-to-use prefilled syringe. It involved 240 healthy adults who received a single injection. The main goal was …

This study aimed to understand how common skin bacteria (staphylococci) and their toxins might worsen eczema and lead to related skin infections like eczema herpeticum. Researchers enrolled 41 adults with moderate to severe eczema to compare samples from their affected skin and b…