ATOPIC DERMATITIS

This study tested a drug called tralokinumab for people with moderate-to-severe atopic hand eczema that hasn't improved with standard treatments. 235 adults received either the drug or a placebo every two weeks for 16 weeks, then everyone got the drug for another 16 weeks. The go…

This study tested whether a moisturizer containing postbiotics (beneficial yeast and bacteria) can lower the chance of eczema returning in children aged 0-6 years whose skin had cleared up. 98 children used either the special moisturizer or a regular one. The goal was to see if t…

This study looked at the long-term safety and effectiveness of lebrikizumab for people with moderate-to-severe atopic dermatitis (eczema). Over 1,100 participants who had already been in earlier lebrikizumab studies were followed for up to 33 months. The main goal was to see how …

This study tested whether teenagers and adults with moderate-to-severe eczema (atopic dermatitis) could successfully give themselves injections of the drug rocatinlimab at home. 151 participants used special injection devices over 16 weeks. The main goal was to see how many full …

This study tested whether a team-based online care model works as well as in-person visits for managing atopic dermatitis (eczema). 300 patients were randomly assigned to either online or in-person care for 12 months. Researchers measured changes in disease severity, quality of l…

This study tested a new medicine called BSI-045B in 22 adults with moderate to severe atopic dermatitis (eczema). Participants received injections weekly for the first month, then every two weeks for 24 weeks. The goal was to see if the treatment safely reduces eczema severity by…

This study tested whether adding dupilumab (an injectable drug) to standard steroid creams can better control eczema in Japanese children aged 6 months to 18 years whose eczema was not helped by existing treatments. The trial involved 62 participants and lasted 16 weeks. The main…

This study tested a daily pill called upadacitinib in over 900 teens and adults with moderate to severe eczema (atopic dermatitis) who needed stronger treatment. The goal was to see if the drug could clear skin and reduce itching better than a placebo. Results showed significant …

This study tested whether methotrexate works as well as cyclosporine for adults with moderate to severe eczema. One hundred participants received one of the two drugs for 24 weeks. The main goal was to see how many people had a 50% improvement in their eczema symptoms after 8 wee…

This study looked at how safe and effective the drug upadacitinib is for teenagers aged 12 to 18 with atopic dermatitis (eczema) in Japan. About 167 teens took the drug as prescribed by their doctor and were followed for up to 2 years. The goal was to see how well it works and wh…

This study tested a drug called tralokinumab in 28 children aged 6 to 12 with moderate-to-severe eczema. The goal was to see how the drug moves through the body and if it is safe. Children received injections over many weeks and used moisturizer daily. The study is complete, but …

This study tested a new medicine called UCB1381 in healthy volunteers and people with moderate to severe atopic dermatitis (eczema). The goal was to check if the drug is safe and if it can improve skin symptoms like redness and itching. Researchers measured side effects and used …

This study tested whether baricitinib, a newer pill, works better than azathioprine, an older pill, for adults with moderate-to-severe eczema. Both were used along with steroid creams. The trial involved 40 adults and measured skin improvement after 12 weeks. The goal was to see …

This study tested a new medicine called UCB9741 in healthy volunteers and people with moderate-to-severe atopic dermatitis (eczema). The main goals were to check if the drug is safe and how the body processes it. Researchers also looked for early signs that it might improve eczem…

This study looked at how dupilumab, a medication for moderate to severe eczema (atopic dermatitis), improves the skin's barrier function in Chinese patients. 44 participants received the drug for 16 weeks, and researchers measured water loss from the skin to see how well the barr…

This study looked at the long-term safety and effectiveness of lebrikizumab for adults and teenagers with moderate-to-severe atopic dermatitis (eczema). Participants who completed a previous year-long study were given lebrikizumab for up to 2 more years. The goal was to see how m…

This study tested a drug called rocatinlimab in 187 teenagers aged 12 to 17 with moderate-to-severe atopic dermatitis (eczema) that didn't improve with standard creams. The main goal was to check the drug's safety over 52 weeks. This is a disease-control treatment, not a cure, me…

This study tested a new medicine called CM310 in 180 teenagers with moderate-to-severe eczema (atopic dermatitis). The goal was to see if it could clear skin and reduce itching better than a placebo. Results showed that more teens using CM310 had significant skin improvement by w…

This study tested a new medicine called camoteskimab in 62 adults with moderate to severe eczema (atopic dermatitis). The goal was to see if it reduces skin redness, itching, and rash better than a placebo over 12 weeks. Participants received either the drug or a placebo, and som…

This study tested a drug called lebrikizumab in 86 adults and teenagers with moderate-to-severe eczema who had already tried dupilumab. The goal was to see if lebrikizumab could safely improve their skin condition. Researchers measured how many participants achieved at least a 75…

This study tested a new medication called SIM0718 in 259 adults and teenagers (ages 12-75) with moderate to severe atopic dermatitis (eczema) that didn't respond well to topical treatments. The goal was to see if the drug could improve skin symptoms like redness and itching bette…

This study tested a new medicine called rocatinlimab, given as an injection, along with standard skin creams, in 746 adults with moderate-to-severe eczema. The goal was to see if the combination could clear the skin and reduce itching better than creams alone. Results showed that…

This study tested a new medication called rocatinlimab for adults with moderate-to-severe atopic dermatitis (eczema) that didn't improve with standard creams. About 769 participants received either the drug or a placebo for 24 weeks. The goal was to see if the drug could clear sk…

This study tested a new drug called AK120 in 450 adults with moderate to severe atopic dermatitis (eczema). The goal was to see if the drug is safe and helps improve skin symptoms like redness and itching. Researchers measured side effects and changes in eczema severity over time…

This study tested a new medication called rocatinlimab in 532 teenagers aged 12 to 17 with moderate-to-severe eczema that didn't improve with standard creams. The goal was to see if the drug could clear skin and reduce itching over 24 weeks. Participants received either the drug …

This study tested a drug called lebrikizumab in 90 adults and teens with moderate-to-severe eczema who have skin of color. The goal was to see if the drug safely improves skin symptoms like redness, itching, and rash over 24 weeks. Participants received the drug as an injection, …

This study tested a daily pill called upadacitinib in 912 teens and adults with moderate to severe eczema that wasn't controlled by creams. Participants received either the drug or a placebo for 16 weeks. The main goals were to see if the drug could clear most of the eczema and r…

This study tested a new treatment called STMC-103H in babies and young children who are at risk for developing allergies because of their family history. The goal was to see if it is safe and can prevent or delay the onset of allergic conditions like eczema and food allergies. Pa…

This study looked at how dupilumab, a medication for moderate to severe eczema, improves the skin's barrier function. Researchers measured water loss through the skin before and after treatment in 52 patients. The goal was to see if the drug helps restore the skin's natural prote…

This study tested an experimental drug called ATI-2138 in 14 adults with moderate to severe atopic dermatitis (eczema). Participants took the drug for 12 weeks to see if it was safe and could improve their skin symptoms. The main goal was to check for side effects, while also mea…

This study tested a special moisturizing cream containing a friendly bacteria called Lactobacillus reuteri to see if it could improve eczema symptoms in children. Forty children aged 6 months to 12 years with mild-to-moderate eczema used the cream for 8 weeks. The researchers mea…

This study tested a cream called VC005 in 118 adults with mild to moderate atopic dermatitis (eczema). The goal was to see if it reduces skin redness, itching, and rash better than a cream with no active ingredient. Researchers measured changes in the Eczema Area and Severity Ind…

This study tested a new cream called PRN473 on 39 adults with mild to moderate eczema. Each person had two patches of eczema treated: one with the study cream and one with a placebo (fake cream) to compare. The main goal was to check safety and how the body processes the cream. T…

This study tested whether a measles vaccine could help improve symptoms of moderate to severe atopic dermatitis (eczema) in adults. Twenty participants received either the vaccine or a placebo and were followed for 45 days. The main goal was to see how the vaccine affected immune…

This study tested whether a new ointment called LNK01004 can safely improve symptoms of atopic dermatitis (eczema) in adults. 75 people with moderate-to-severe eczema applied either a low dose, high dose, or a placebo cream twice daily for 8 weeks. The main goal was to see how mu…

This early-stage study tested an oral medication called KT-621 in 22 adults with moderate to severe atopic dermatitis (eczema). The main goal was to check the drug's safety and how the body handles it. Researchers monitored side effects and drug levels in the blood. This is a fir…

This early-stage study tested an experimental pill called soquelitinib in 82 adults with moderate to severe atopic dermatitis (eczema). The main goal was to check if the drug is safe and tolerable compared to a placebo. Researchers also looked at whether it could reduce eczema se…

This study looked at how well the drug upadacitinib works for people in Japan with moderate to severe eczema that also causes hard, itchy bumps called prurigo nodularis. About 200 adults and teens took the drug once daily for 48 weeks. The main goal was to see if their worst itch…

This study tested two creams—crisaborole and fluticasone—on 40 children aged 1 to 12 with mild to moderate eczema. Both creams were applied twice daily for 6 weeks, then twice weekly for 12 weeks if the skin improved a lot. Both treatments helped reduce itching and skin redness, …

This early-stage study tested a new medicine called CM512 in 110 healthy volunteers and people with moderate to severe atopic dermatitis (eczema). The main goal was to check safety and how the body processes the drug. Researchers gave either a single or multiple doses and compare…

This study tested whether a daily probiotic supplement (Bifidobacterium longum) can reduce eczema symptoms in infants and toddlers aged 3 months to 3 years. 100 children with atopic dermatitis were split into two groups: one received the probiotic, the other a placebo. Over 3 mon…

This study tested a new medicine called LEO 138559 (also known as Temtokibart) in 262 adults with moderate-to-severe eczema. Participants received different doses or a placebo as injections under the skin for 16 weeks. The goal was to see if the drug safely reduces eczema severit…

This study tested whether adding vitamin K2 (45 mg daily for 12 weeks) to standard treatment can reduce eczema severity in 100 children aged 6-12 with moderate-to-severe atopic dermatitis. The main goal was to see if the SCORAD score improved. The study is complete, but results a…

This study tested whether dupilumab, an injectable drug, improves sleep in 188 adults with moderate to severe eczema who also had trouble sleeping. Participants received either dupilumab or a placebo for 12 weeks. The main goal was to measure changes in sleep quality and itch sev…

This study tested a cream called tapinarof for people aged 2 and older with moderate to severe eczema (atopic dermatitis). Over 400 participants applied the cream or a placebo daily for 8 weeks. The main goal was to see if the cream could make skin clear or almost clear. The stud…

This study tested an experimental drug called LNK01001 in 356 adults with moderate to severe atopic dermatitis (eczema) that didn't improve enough with standard creams or other treatments. Participants received either the drug or a placebo pill for 16 weeks. The main goals were t…

This study tested whether a special behavior-change program (EMD-U) added to usual care improves skin-related quality of life in adults with atopic dermatitis or prurigo nodularis who scratch severely. 96 participants were randomly assigned to either the program plus usual care o…

This study tested a cream called tapinarof in 407 children and adults with moderate to severe atopic dermatitis (eczema). The goal was to see if the cream could clear or almost clear the skin rash by 8 weeks compared to a placebo cream. Participants applied the cream daily, and d…

This study looked at how well a moisturizing cream (RV4427C WM0071) works for adults with moderate-to-severe atopic dermatitis (eczema) that is already being managed with systemic treatments like pills or injections. About 80 participants used the cream and answered questionnaire…

This early-stage study tested a new medicine called BSI-045B in 54 healthy adults and people with eczema (atopic dermatitis). The main goal was to check if the drug is safe and tolerable. Researchers also looked at how the drug works in the body and whether it can improve eczema …

This study tested a special cream containing a substance called butyrate, which is naturally found in the skin, to see if it helps children aged 6 to 36 months with eczema. The cream aims to improve the skin barrier and reduce inflammation. The study involved 100 children and mea…

This study looked at whether adding Chinese herbal medicine to standard care can help people with moderate to severe atopic dermatitis (eczema). Nineteen people aged 6 to 30 took part. Researchers measured skin symptoms and quality of life before and after treatment to see if the…

This study looked at how safe a new cream called tapinarof is for children aged 2 to 17 with moderate to severe eczema covering large areas of their body. Researchers checked for side effects and measured how much of the drug got into the bloodstream. The goal was to see if the c…

This study tested a cream called ruxolitinib on adults with moderate eczema (atopic dermatitis) who had not gotten better with standard steroid creams. The goal was to see if the cream could reduce skin redness, swelling, and itching. 241 adults took part, and the study compared …

This study tested a new ointment called YR001 in 35 adults with mild to moderate atopic dermatitis (eczema). The main goal was to check safety and how the body processes the ointment. Researchers also looked at whether it improved skin symptoms. The trial was completed and compar…

This study looked at the types of fungi living on the skin of 30 adults with eczema (atopic dermatitis) affecting the head and neck, compared to healthy volunteers. The goal was to understand if an imbalance in skin fungi contributes to eczema in these areas. Researchers used adv…

This study tested a single dose of rocatinlimab in 20 healthy Chinese adults to see how the drug moves through the body and if it is safe. The goal was to gather information, not to treat any disease. Participants were monitored for side effects and drug levels in the blood.

This study looked at how dupilumab affects the immune cells and genes inside the skin of people with moderate-to-severe eczema. Seventeen adults took the drug and had skin samples tested before and after 12 weeks of treatment. The goal was to understand how the medicine works at …

This study looked at how staphylococcus bacteria on the skin affect eczema (atopic dermatitis) and related viral infections like eczema herpeticum. Researchers compared skin and blood samples from 41 adults with moderate to severe eczema to healthy skin. The goal was to understan…

This study looked at 80 adults with moderate-to-severe eczema whose skin was under control with prescription medications. Researchers wanted to understand how these patients use moisturizers, what they expect from them, and how their skin feels. The goal was to gather information…

This study looked at the genes in the skin of 433 people with eczema (atopic dermatitis) to find patterns that separate mild from severe disease. Researchers also checked how standard treatments like steroid creams and dupilumab change those gene patterns over time. The goal was …

This early-phase study looked at how rocatinlimab changes the way the body processes certain other medications in 21 adults with moderate to severe atopic dermatitis (eczema). Participants received a cocktail of common drugs before and after rocatinlimab to measure differences in…

This study looked at how Staphylococcus aureus (staph) bacteria, commonly found on eczema-affected skin, might cause disease flares. Researchers applied staph bacteria or their toxins to the skin of 7 people with eczema and healthy volunteers to see if it triggers inflammation. T…

This study looked at how the body processes rocatinlimab when given as a shot from a vial versus a prefilled syringe. It involved 240 healthy adults aged 18 to 65. The goal was to see if both methods work the same way, not to treat any disease.

This study looked at whether rocatinlimab, a drug for moderate-to-severe eczema, changes how well vaccines work. 221 adults with eczema received either rocatinlimab or a placebo, then got tetanus and meningococcal vaccines. The goal was to see if the drug affects the body's abili…

This study followed 487 mothers and their babies to see if key nutrients like folate and vitamin D during early pregnancy are linked to eczema (atopic dermatitis) in infants up to 6 months old. Researchers measured nutrient levels in the mothers' blood and checked babies for ecze…

This study looked at how parents of infants with early eczema and parents of healthy infants use a mobile-friendly website called OneBiome to track their baby's gut bacteria and eating patterns. The goal was to see if parents found the reports easy to understand and useful. No tr…

This study followed 461 children ages 6-8 whose mothers took a special nutritional drink before and during pregnancy. Researchers measured the children's growth, body composition, thinking skills, and metabolism to understand how parents' diet and lifestyle early on influence lon…

This study looked at skin samples from 170 people with psoriasis, atopic dermatitis, or healthy skin to understand how a protein called Lyn is involved in inflammation. Researchers measured Lyn levels and activity, along with other inflammatory markers. The goal was to see if a s…

This study looked at how an experimental medicine for atopic dermatitis (eczema) behaves in the body when made in different versions. Twelve healthy adults each took five different pill forms—some fast-acting, some slow-release—both on an empty stomach and after a high-fat meal. …

This early-stage study tested a new drug called 9MW1911 in 48 healthy adults to see if it is safe and how the body processes it. No treatment was given for any disease. The results will help decide safe doses for future studies in people with asthma, COPD, or atopic dermatitis.

This early-stage study tested a single dose of the SM17 antibody in 30 healthy Chinese adults to see if it is safe and how the body processes it. The goal was not to treat any disease, but to gather important safety and drug-level information. No direct benefit was expected for p…

This study tested how well the drug rocatinlimab enters the body when given by an autoinjector pen versus a traditional vial and syringe. 231 healthy adults aged 18 to 60 received a single dose. The goal was to compare drug levels and check for side effects, not to treat eczema.

This study looked at eye problems in 100 adults with atopic dermatitis (eczema) who were treated with tralokinumab. The main goal was to find out how often eye issues like conjunctivitis happen with this medication. Researchers followed participants for 4 months to track any new …

This study tested a new microneedle patch to collect fluid from the skin of 20 healthy volunteers and people with eczema (atopic dermatitis). The goal was to see how much fluid could be collected and how well it was tolerated. This early-stage research aims to improve how we samp…

This study tested specially engineered versions of a natural immune protein (IL-2) in blood samples from 67 people with autoimmune or inflammatory diseases like lupus, multiple sclerosis, and rheumatoid arthritis. The goal was to see if these modified proteins could selectively a…