Uveitis

This study tests whether certolizumab pegol (Cimzia), a drug already used for arthritis, can reduce flares of anterior uveitis—a painful eye inflammation—in people with axial spondyloarthritis who have had uveitis before. About 89 adults with active axial spondyloarthritis and a …

This study tested whether analyzing a patient's DNA and RNA could help doctors pick the right drug for inflammatory diseases that don't fit standard categories. 32 adults with at least two affected organs (including skin) received one of six targeted therapies based on their mole…

This phase 3 trial tested TRS01 eye drops in 142 people with active non-infectious anterior uveitis, an inflammatory eye condition that can cause pain and vision loss. Participants used the drops four times a day, and researchers measured how well the drug reduced inflammation co…

This study tested two different steroid eye drops—loteprednol and prednisolone—in 66 children with inflammatory nodules in the front part of the eye. The goal was to see if loteprednol could control inflammation as well as prednisolone while causing fewer increases in eye pressur…

This completed phase 4 trial tested whether a rapid weight loss program using semaglutide (Ozempic/Wegovy) plus a very low calorie diet can help people with idiopathic intracranial hypertension (IIH), a condition where high pressure in the skull causes headaches and vision proble…

This study looked at 30 people with Vogt-Koyanagi-Harada (VKH) disease, a rare autoimmune condition that causes eye inflammation and can lead to vision loss. Researchers compared two initial treatments: oral prednisolone (steroid pills) and steroid injections near the eye. They c…

This study followed 30 uveitis patients who received a fluocinolone acetonide implant to control eye inflammation. Researchers used advanced imaging (OCT, OCTA, fluorescein angiography) to track changes in inflammation over 12 months. The goal was to see if imaging could better m…

This study tested whether a weekly injection of abatacept (Orencia) plus usual care could prevent juvenile idiopathic arthritis (JIA) from spreading to more joints or causing eye inflammation. 121 children with recent-onset JIA affecting 4 or fewer joints took part. The goal was …

This study tested what happens when patients with rheumatoid arthritis, Crohn's disease, or eye inflammation switch from the original drug Remicade to its lower-cost biosimilar Inflectra. Over 260 adults who had been on Remicade for at least 4 months were switched. The main goal …

This study tested ACTH gel, given as a shot under the skin, in 28 people with non-infectious uveitis (eye inflammation not caused by an infection). The goal was to see if it is safe and can help control inflammation. Participants received one of two doses, and researchers tracked…

This study tests a daily pill called ALK-001, a modified form of vitamin A, to see if it can slow the growth of geographic atrophy—an advanced form of dry age-related macular degeneration that causes blind spots. About 300 people with the condition took either the drug or a place…

This study tested three biologic drugs—adalimumab, anakinra, and tocilizumab—in 112 people with severe, treatment-resistant uveitis, an inflammatory eye disease that can cause blindness. Participants received one of the drugs for 16 weeks. The goal was to see which drug best redu…

This small study tested ustekinumab, a drug that calms the immune system, in 16 adults with Behçet disease. The goal was to see if it could reduce mouth ulcers and eye inflammation. The trial is complete, but because it's early and small, we don't yet know if the drug will become…

This study tested the drug adalimumab against a placebo in 34 children with juvenile arthritis and active eye inflammation (uveitis) that wasn't controlled by steroid drops or methotrexate. The goal was to see if adalimumab could reduce eye inflammation after two months. After th…

This study tested a new method called metagenomic deep sequencing (MDS) to find the cause of eye infections. 100 adults with suspected infectious uveitis or endophthalmitis were randomly assigned to have their doctors receive MDS results or not, in addition to standard tests. The…

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This study looked at whether a new, high-resolution MRI can help doctors more accurately and confidently diagnose the cause of optic disc swelling (a sign of various eye or brain problems). Researchers used these detailed scans on 197 adults with optic disc swelling to see if the…

This early study tested a new radioactive tracer called 18F-FDS in 16 people with suspected bacterial or fungal infections. The tracer is designed to light up infection sites on PET/CT scans, helping doctors see exactly where an infection is. The goal was to check how the tracer …

Researchers tested an artificial intelligence program that analyzes retinal images to diagnose several nerve and brain conditions, such as optic neuropathy and brain tumors. The study used data from 693 patients with confirmed diagnoses. The goal is to create a fast triage tool f…

This study tested whether a smartphone meditation app (Calm Health) could help reduce anxiety and depression in 100 adults with non-infectious uveitis, an inflammatory eye disease. Participants used the app and reported their symptoms. The goal was to see if digital mindfulness c…

This study tested whether a tiny eye insert called DEXTENZA, placed after cataract surgery, works better than standard eye drops alone for reducing pain and swelling. Fifty adults having cataract surgery took part. The insert slowly releases medicine over time, aiming to improve …

This completed study looked at how the social networks of caregivers affect their stress and health when caring for someone with an inherited disease. Researchers surveyed over 680 participants, including family members and formal caregivers, to understand caregiving burden and s…

This study looked at the natural bacteria in the gut of 131 adults with and without uveitis, an inflammatory eye disease. Researchers collected stool and blood samples and performed eye exams to see if differences in gut bacteria are linked to eye inflammation. No treatment was g…

This study collected blood, saliva, and eye fluid samples from 343 people with uveitis, an inflammatory eye disease that can cause vision loss. Researchers aimed to learn which genes and other factors might lead to the disease and affect treatment response. Participants were foll…

This study compared gum health and levels of inflammatory substances in the mouth and blood of 25 people with non-infectious uveitis (an eye inflammation) and 27 healthy individuals. Researchers measured gum pocket depth, bleeding, and cytokines like TNF-α and IL-10. The goal was…

This study followed 76 women with congenital toxoplasmosis (a parasitic infection present from birth) to see if pregnancy increases the risk of eye inflammation (retinochoroiditis). Researchers checked eye exams done during pregnancy and after childbirth, comparing them to non-pr…

This study looked at over 550,000 people who received Eylea® injections for eye conditions to find out how often retinal vasculitis (a rare eye inflammation) occurs. Researchers used a large US registry and medical records to confirm cases. The goal was to better understand the s…

This completed study analyzed data from nearly 290,000 patients who received aflibercept (Eylea) injections for various retinal diseases. The goal was to estimate how often retinal vasculitis (inflammation of blood vessels in the eye) occurs in real-world clinical practice. Resea…

This study looked at the brain's lymphatic system in 40 women with idiopathic intracranial hypertension (IIH), a condition causing severe headaches and vision loss. Researchers used a special MRI technique to compare lymphatic vessels in patients and healthy controls. The goal wa…

This study looked at 905 people with uveitis, an eye inflammation, to see if a standardized step-by-step diagnostic plan works as well as letting doctors choose any tests they want. The goal was to find the cause of the uveitis more efficiently and at a lower cost. Researchers co…