Uveitis

This study tests whether oral valganciclovir or ganciclovir eye drops can reduce the virus causing eye inflammation and prevent flare-ups. About 117 adults with CMV anterior uveitis will receive either antiviral treatment or placebo for 7 days, then some continue for 12 months. T…

This trial investigates whether children and young adults with juvenile idiopathic arthritis (JIA)-related uveitis can safely take adalimumab injections less frequently without their eye or joint inflammation returning. Participants are assigned to receive injections every 2, 4, …

This trial investigates whether people with chronic non-infectious uveitis—an eye condition that can cause blindness—can safely reduce their dose of adalimumab (a drug that calms the immune system) by using regular blood tests to monitor drug levels. Participants whose uveitis ha…

This study will follow 100 adults with non-infectious posterior uveitis, a chronic inflammatory eye disease, who have received a fluocinolone acetonide implant. Researchers will analyze medical records over three years to see how well the implant reduces the frequency and severit…

This early-stage study tests a one-time cell therapy called TRX103 for people with active non-infectious uveitis, a condition causing inflammation inside the eye. Up to 18 adults aged 18 to 70 will receive the treatment by IV and be monitored for a year. The main goal is to check…

This study tests whether the drug upadacitinib can reduce how often people with axial spondyloarthritis (a type of arthritis affecting the spine) get sudden eye inflammation (acute anterior uveitis). About 200 adults who have had at least one eye flare in the past year will take …

This study will test a new, non-invasive eye scanner called wide field OCTA in 200 people with various eye diseases, including age-related macular degeneration, diabetic retinopathy, and dry eye. The goal is to see if this device can provide better images of blood vessels in the …

This study tests whether a short course of the steroid prednisolone can prevent paradoxical immune reconstitution inflammatory syndrome (IRIS) in people with AIDS who have low CD4 counts and are starting HIV treatment. About 131 participants will receive either prednisolone or no…

This observational study will use advanced imaging techniques to measure changes in the retina and choroid (the layer beneath the retina) in people with eye diseases and healthy volunteers. Over 5 years, researchers will track thickness and blood vessel density to better understa…