Could fewer injections keep kids' eye inflammation in check?
NCT ID NCT07699107
First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time
Summary
This trial investigates whether children and young adults with juvenile idiopathic arthritis (JIA)-related uveitis can safely take adalimumab injections less frequently without their eye or joint inflammation returning. Participants are assigned to receive injections every 2, 4, 8, or 12 weeks and are monitored for 24 weeks, with a follow-up at 48 weeks. The goal is to find the least frequent dosing schedule that still keeps the disease under control.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- adalimumab (a biologic drug that reduces inflammation)
- What this could lead to
- If successful, this could allow children with JIA-related uveitis to take fewer injections while still controlling eye and joint inflammation.
- What could go wrong
- This is a Phase 4 trial with 160 participants, so results may not apply to all patients. Less frequent dosing might lead to disease flare-ups in some children.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Alder Hey Children's Hospital
Liverpool, L14 5AB, United Kingdom
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Children's Mercy Hospital
Kansas City, Missouri, 64108, United States
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Cincinnati Children's Hospital
Cincinnati, Ohio, 45229, United States
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Great North Children's Hospital
Newcastle upon Tyne, NE1 4LP, United Kingdom
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Great Ormond Street Hospital
London, WC1N 3JH, United Kingdom
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Manchester University NHS Foundation Trust
Manchester, M13 9WL, United Kingdom
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Meyer Children's Hospital
Florence, 50139, Italy
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Norfolk and Norwich University Hospital
Norwich, NR4 6TZ, United Kingdom
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Sheffield Children's Hospital
Sheffield, S10 2TQ, United Kingdom
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University Hospitals Bristol and Weston
Bristol, BS1 3NU, United Kingdom
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University Hospitals of Leicester
Leicester, LE1 5WW, United Kingdom
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University of California, Davis
Sacramento, California, 95817, United States
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University of California, Los Angeles
Los Angeles, California, 90095, United States
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University of California, San Francisco
San Francisco, California, 94143, United States
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University of Miami
Miami, Florida, 33136, United States
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University of Texas, Austin
Austin, Texas, 78712, United States
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University of Utah Health
Salt Lake City, Utah, 84132, United States
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Vanderbilt University Medical Center
Nashville, Tennessee, 37212, United States
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