Uveitis

This study tests NOV05, a water-free tacrolimus eye drop, in 20 adults with active non-infectious anterior uveitis. Participants receive either a high or low dose for 6 weeks. The goal is to see if it safely controls inflammation and reduces the need for steroid eye drops.

This study tests a new drug, GenSci048, in people with active non-infectious uveitis, an inflammatory eye disease. The trial will compare two doses of GenSci048 against a placebo to see if it can control the disease and reduce treatment failure. About 111 adults with active uveit…

This study tests the drug adalimumab (Tebiovio®) in 30 adults with non-infectious uveitis, an inflammatory eye disease. The goal is to see if the drug can control inflammation and prevent treatment failure. Participants will receive injections and be monitored for up to 24 weeks.…

This study tests whether faricimab (Vabysmo), an FDA-approved eye injection for other retinal diseases, can safely treat abnormal blood vessel growth in the eye caused by presumed ocular histoplasmosis syndrome. About 25 adults with this condition will receive an initial injectio…

This study tests a new treatment called LB-DTK-CMV for people with cytomegalovirus (CMV) retinitis that has not responded to standard antiviral medicines. The treatment uses a patient's own immune cells, specially trained to attack CMV, and is given as two infusions. The trial ai…

This early-stage trial tests an oral drug called DF-003 in 12 people with ROSAH syndrome, a rare genetic condition causing eye inflammation, enlarged spleen, and headaches. The main goal is to check safety and how the body processes the drug, while also watching for improvements …

This study looks at whether starting strong immune-suppressing drugs early can help control Vogt-Koyanagi-Harada (VKH) disease, a rare condition that causes eye inflammation and vision loss. Researchers will treat 40 newly diagnosed patients with high-dose steroids and other immu…

This study tests an oral medication called FXS5626 in 40 adults with active non-infectious uveitis, a condition causing inflammation inside the eye. The goal is to see if the drug can control the disease better than a placebo, reducing the need for other treatments. Participants …

This study compares two common procedures—CSF shunting and dural venous sinus stenting—to see which better preserves vision in adults with idiopathic intracranial hypertension (IIH) who are at risk of permanent sight loss. About 80 participants will be randomly assigned to one of…

This study tests special lens implants that correct both cataracts and presbyopia (age-related blurry near vision) in patients with additional eye structure issues like lens dislocation or inflammation. About 320 adults will receive these lenses during cataract surgery, with doct…

This study tests a new diagnostic method called metagenomic sequencing to find hidden infections in people with eye inflammation (uveitis). Standard tests often miss the cause. Researchers will analyze fluid from the eye to detect bacteria, viruses, fungi, or parasites. The goal …

This study tests a smartphone app that uses artificial intelligence to detect 16 different eye diseases from photos taken with the phone. The AI works entirely on the device, so no internet is needed. Researchers will compare its accuracy to eye doctors and see if non-medical use…

Infectious uveitis is a serious cause of blindness, but current tests often miss the culprit. This study uses a broad panel of molecular tests to detect bacteria, viruses, and fungi in eye fluid from 100 patients with suspected infectious uveitis in China. The goal is to map whic…

This study is observing 300 children under 18 with uveitis, an eye inflammation condition. Researchers want to learn how common different types of uveitis are and what treatments children receive. Participants have one visit with their doctor, and some will have their medical rec…

This study is tracking 290 children with non-infectious chronic uveitis, a rare eye inflammation that can cause vision loss. Researchers will collect data on symptoms, lab results, and complications over several years. The goal is to better understand the disease and identify ris…

This study follows 600 people with birdshot chorioretinopathy, a rare inflammatory eye disease, to better understand its features and causes. Researchers will use imaging, vision tests, and quality-of-life surveys to track the disease over time. They will also analyze DNA to find…

This study is testing whether a special eye scan (OCT) can accurately measure inflammation inside the eye for people with uveitis. Researchers will scan the eyes of 1500 patients and compare the results to standard exams. The goal is to find a faster, painless way to track diseas…

This study aims to uncover genetic mutations or variations linked to uveitis, an inflammatory eye disease. Researchers will collect blood samples from 1,500 patients with uveitis (including infectious types) and analyze their DNA. The goal is to better understand what causes the …

This study collects tissue and blood samples from 300 people with autoimmune diseases like Crohn's, multiple sclerosis, and celiac disease. Researchers aim to identify the specific targets of immune cells (T cells) that cause inflammation. The goal is to discover new targets for …