Can a gel tame eye inflammation? new trial tests ACTH for uveitis

NCT ID NCT02931175

Completed Disease control Sponsor: Quan Dong Nguyen Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested ACTH gel, given as a shot under the skin, in 28 people with non-infectious uveitis (eye inflammation not caused by an infection). The goal was to see if it is safe and can help control inflammation. Participants received one of two doses, and researchers tracked side effects and changes in eye haze over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ACTH gel (corticotropin)
What this could lead to: If successful, this could provide a new treatment option for controlling inflammation in non-infectious uveitis, potentially reducing reliance on steroids.
What could go wrong: This is a small, early-phase (Phase 2) study with only 28 participants, so results may not apply to all patients. The treatment may cause side effects and may not work better than existing therapies.

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Conditions

The condition(s) this trial relates to.

intermediate uveitis posterior uveitis uveitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

UVEITIS

Contacts and locations

Locations

Metropolitan Eye Research and surgery Institute

Waltham, Massachusetts, 02451, United States
Retina Centers Professional Corporation - RCPC

Cleveland, Ohio, 44139, United States
Retina Consultants of Houston

Bellaire, Texas, 77401, United States
Retina Vitreous Associates, Medical Group

Los Angeles, California, 90017, United States
Stanford University

Palo Alto, California, 94303, United States
TExas Retina Associates

Dallas, Texas, 75231, United States
Texas Retina Assiciates

Dallas, Texas, 75231, United States

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