Subarachnoid hemorrhage

Researchers compare two approaches for adults with small unruptured brain aneurysms found by chance: regular imaging surveillance without initial treatment, or immediate endovascular or surgical repair. The trial enrolls 600 adults aged 35 to 75 with aneurysms measuring 2 to 7.9 …

Researchers are testing whether adding tirofiban to standard antiplatelet therapy improves recovery for people whose ruptured brain aneurysm is repaired with a stent. The trial enrolls adults with acute subarachnoid hemorrhage who receive stent-assisted coiling within 72 hours of…

This study tests a community-based exercise program for people aged 50 and older who have at least two chronic conditions, such as heart disease, diabetes, arthritis, or obesity. The program is designed to improve muscle strength, heart and lung fitness, and overall well-being. R…

This trial tests whether adding a traditional Chinese medicine, Angong Niuhuang Pill, to standard stroke care can improve outcomes for adults who have just had a stroke. The study uses an adaptive platform design, allowing multiple treatments to be tested simultaneously and effic…

This study tests whether huperzine A, an injected drug, can help prevent or reduce memory and thinking problems that often follow surgery for a bleeding brain aneurysm. Adults aged 18-70 who had an aneurysm bleed and underwent endovascular or surgical treatment will receive eithe…

This trial tests whether a simple, non-invasive technique called remote ischemic preconditioning (RIPC) can reduce brain damage after an aneurysmal subarachnoid hemorrhage, a severe type of stroke. The procedure involves briefly inflating a blood pressure cuff on the leg to restr…

This early study tests whether a drug called sirolimus (rapamycin), given directly into the brain's fluid spaces, can prevent hydrocephalus after a severe brain hemorrhage. Hydrocephalus is a dangerous buildup of fluid that often requires a permanent surgical shunt. The trial wil…

This study tests whether a stellate ganglion block (a nerve block injection) can improve neurological outcomes in people who have had a bleeding stroke from a ruptured aneurysm. The procedure is done before surgery to reduce brain artery spasms and improve blood flow. Researchers…

This study tests whether giving aspirin early after repairing a ruptured brain aneurysm helps patients recover better. About 388 adults who had a bleeding aneurysm will receive either aspirin or a placebo for 10–14 days. The goal is to see if aspirin reduces brain complications a…

This study tests whether a personalized weaning strategy can help adults with chronic heart, brain, or lung conditions leave ventilators earlier. The strategy tailors care based on the main reason a patient struggles to breathe on their own, such as heart or muscle problems. Rese…

This study tests a drug called tirofiban (Aggrastat) in 82 people who have had bleeding from a brain aneurysm. The drug is given through a vein to prevent blood clots that can cause delayed brain damage. The main goal is to find the safest dose, while also checking if it reduces …

This study tests whether a device that gently stimulates a nerve in the ear can reduce brain damage and inflammation after a traumatic brain injury or bleeding stroke. Sixty adults will be randomly assigned to receive either real stimulation or a sham (fake) treatment. Researcher…

This study looks at whether giving extra oxygen through a facemask can help people who have had a brain aneurysm bleed and are breathing too fast, causing low carbon dioxide levels. About 80 adults with this condition will receive the oxygen treatment to see if it reduces the ris…

This study tests whether giving magnesium sulfate early through an IV can reduce dangerous narrowing of brain arteries after a traumatic brain bleed. About 50 adults with head injuries will receive the treatment within 24 hours. The goal is to see if it lowers the risk of delayed…

This study tests whether the drug cilostazol can prevent delayed brain injury in people who have had a bleeding stroke from a burst aneurysm. About 316 adults will receive either cilostazol or a placebo for 14 days. The goal is to see if the drug reduces the risk of delayed brain…

This study tests whether adding cilostazol, a drug that improves blood flow, to standard nimodipine treatment helps people recover better after a brain aneurysm rupture. Researchers will enroll 630 adults in France within 96 hours of the bleed and follow them for 6 months. The go…

This study tests whether raising or lowering blood pressure after aneurysm repair improves outcomes in people with a brain bleed. 750 adults who had surgery within 72 hours will be randomly assigned to different blood pressure targets. Their recovery will be tracked for 6 months …

This trial tests whether two non-invasive tools can help paramedics detect dangerously high pressure inside the skull in patients with sudden brain injury, such as stroke or head trauma, before they reach the hospital. The tools are a wearable sensor placed on the head and an ult…

This study will check if an artificial intelligence (AI) system can accurately score stroke severity as well as a trained doctor. About 297 adults with a recent stroke will have their speech and facial movements recorded. The AI will analyze these recordings to produce a G-FAST s…

This trial tests whether ticagrelor, an antiplatelet drug, can prevent stroke and delayed brain ischemia in people who have had a low-grade aneurysmal subarachnoid hemorrhage. Participants receive either ticagrelor or a placebo for 14 days, starting just before endovascular treat…

This study tests whether giving a calcium channel blocker (nicardipine) through a lumbar drain can prevent dangerous artery spasms and delayed brain damage in people who have had a brain bleed from a ruptured aneurysm. About 214 adults with mild to moderate bleeds will receive th…

This study tests a new approach to prevent delirium (sudden confusion) in patients with a type of stroke called subarachnoid hemorrhage who are in the intensive care unit. The program combines standard medical care with basic body awareness therapy and video-based communication. …

Researchers test whether infusing lidocaine into the middle meningeal artery reduces headache severity in adults who have had a bleeding brain aneurysm. Participants receive either lidocaine or a saline placebo during their endovascular aneurysm repair. The trial measures headach…

This trial tests whether different types of pressure garments can improve touch sensation in the hand after a stroke. Adults aged 21 to 60 with hand stiffness will wear one of three garment designs for at least 12 hours daily over four weeks. Researchers will measure how the pres…

This study tests whether having a neurologist consult via video during ambulance transport helps decide the best hospital for suspected stroke patients. About 484 adults with stroke symptoms will be randomly assigned to standard care or standard care plus a telemedicine consultat…

This large registry study will follow over 2,700 postmenopausal women aged 45-75 who use newer forms of hormone replacement therapy (creams, gels, sprays). The goal is to see if these modern delivery methods lower the risk of heart attacks, strokes, and other cardiovascular event…

After a severe brain injury, some patients survive but cannot communicate, and it is difficult to predict who will recover consciousness. This observational study in Cyprus is testing whether a brain-wave monitoring technique called the bispectral index (BIS) can improve predicti…

This study investigates why some people develop long-term thinking and memory problems after surgery to repair a ruptured brain aneurysm. Researchers will review past medical records and then bring in 150 adult survivors for brain scans and cognitive tests. The goal is to identif…

This study uses a non-invasive forehead sensor to continuously monitor brain oxygen levels in 120 patients with subarachnoid hemorrhage (a type of stroke caused by bleeding around the brain). The goal is to see how the brain's ability to regulate blood flow changes over time and …

This study will track 1000 adults who had a brain bleed from a burst aneurysm. The goal is to learn how often delayed brain injury happens and how doctors currently diagnose and treat it. By comparing different hospital approaches, researchers hope to find better ways to prevent …

This study tests two strategies for removing an external ventricular drain (a tube that drains fluid from the brain) in 170 adults who had a brain bleed. One method clamps the drain shut as soon as it's safe, while the other gradually raises the drain over time. The goal is to se…

This study tests if a non-invasive device called Electrical Impedance Tomography (EIT) can safely monitor brain blood flow in 100 ICU patients with conditions like stroke or brain bleeding. Currently, doctors must insert a probe into the skull to check this, which can cause infec…

This study will observe 300 adults in the intensive care unit with serious brain conditions like bleeding, stroke, or injury. Researchers will use noninvasive monitors to track brain activity and blood flow, linking this data to patients' recovery. The goal is to better understan…

This study looks at 300 adults with a brain bleed from a ruptured aneurysm. It tests a non-invasive headband to monitor brain blood flow and two nerve treatments (a neck injection and ear stimulation) to see if they improve brain function. The goal is to find better ways to preve…

This study compares two ways to perform brain angiography: accessing an artery through the wrist (transradial) versus the groin (transfemoral). Over 2,400 people needing this imaging test will be randomly assigned to one method. Researchers will measure success rates, complicatio…

This study will look at medical records of 170 patients aged 70 and older who were in the ICU for a bleeding stroke called aneurysmal subarachnoid hemorrhage. Researchers want to find out which factors are linked to poor recovery or death six months later. The goal is to help doc…

This study aims to develop a new EEG-based technique to detect 'cognitive-motor dissociation'—where a patient is aware but cannot move. Researchers will stimulate the median nerve (in the wrist) and analyze brain signals in 50 comatose ICU patients. The goal is to identify those …

This study will look at brain scans (MRI/CT) and symptoms of over 1,100 people with cerebrovascular disease. The goal is to find patterns linking specific scan findings to different types of the disease. This could help doctors diagnose and treat these conditions more accurately …

This study looks at blood markers related to inflammation and clotting in people who have had a stroke or a brain bleed. Researchers want to see how these markers change over time and differ between patients with complications. About 499 adults will give blood samples at five tim…

This study will check how common thinking and memory problems are in people who have had their first stroke. Researchers will evaluate 400 adults aged 18 to 60 within three months of their stroke. The goal is to better understand the impact of stroke on the brain, not to test a n…

This study will observe 125 adults with confirmed stroke to see how factors like symptom awareness, calling emergency services, and transport time affect their recovery. No new treatment is given; instead, researchers will measure stroke knowledge and care pathways to find ways t…