Subarachnoid hemorrhage

This study tests whether a program called iHeLP is practical and acceptable for stroke survivors. The program includes a one-on-one interview to set personal goals, followed by six weekly group sessions focused on healthy lifestyle changes. Researchers will measure how many peopl…

This study investigates whether a noninvasive brain stimulation technique called transcranial direct current stimulation (tDCS) can enhance recovery from spatial neglect — a condition where stroke survivors ignore one side of their world. Participants who had a stroke 3 to 12 mon…

This study tested whether giving a clot-busting drug directly into the brain's fluid spaces could save lives after a severe brain bleed caused by a burst aneurysm. Nineteen patients with heavy bleeding inside the brain's chambers received the treatment. The main goal was to see i…

This study tested whether a medicine called milrinone, given through a vein, can help people recover better from a serious type of stroke called subarachnoid hemorrhage. After this stroke, many patients develop dangerous spasms in brain arteries that can cause further brain damag…

This study tested two types of nerve blocks (superior cervical sympathetic block and stellate ganglion block) to treat blood vessel spasms in the brain after a traumatic head bleed. The goal was to improve blood flow and prevent further brain damage. The study included 60 adults …

This study tested whether a nurse-led safety program using checklists can reduce complications in patients undergoing emergency surgery for a brain bleed (subarachnoid hemorrhage). 156 adults were randomly assigned to receive either standard nursing care or standard care plus the…

This study tested whether giving a sedative called dexmedetomidine during a procedure to fix a brain aneurysm can prevent dangerous blood vessel spasms. 90 adults who had a brain bleed from a ruptured aneurysm took part. The goal was to see if the drug reduces complications and i…

This study tested whether tiopronin, a drug used for liver disease, can lower a harmful chemical in the brain and improve recovery after a bleeding stroke from a burst aneurysm. Sixty patients received either tiopronin or a placebo for up to 14 days. The goal was to see if the dr…

This trial evaluates the safety and feasibility of a portable, low-field MRI device called Axana for imaging the brain in people with suspected stroke. Researchers will compare scans from the Axana device with standard hospital MRI scans in 60 adults, including healthy volunteers…

This study tested whether a non-invasive device placed on the forehead (NIRS) can detect blood vessel spasms in the brain after a severe aneurysm rupture. Fifty patients were monitored continuously from day 4 to day 12 after their bleed. The goal was to see if this oxygen-measuri…

This study tested whether a special ultrasound of the eye's main artery can help doctors diagnose increased pressure inside the skull. Researchers measured blood flow in the central retinal artery of 66 patients with stroke or traumatic brain injury. The goal was to see if change…

This trial tests whether adding music therapy to standard rehabilitation helps people recover better after serious neurological injuries like stroke, brain injury, or spinal cord damage. About 75 participants aged 16-80 will be randomly assigned to receive either music therapy or…

This study tested whether draining some fluid from the spine (a lumbar puncture) can help relieve severe headaches that often follow a brain aneurysm rupture. The trial involved 74 patients with mild to moderate brain bleeds. Half received a real lumbar puncture, and half receive…

This study tested whether a non-invasive brain stimulation technique called tDCS, combined with balance and walking exercises, could help stroke survivors improve their mobility and thinking. Thirty adults who had a stroke participated. The results suggest tDCS may enhance rehabi…

This study looks at people with acute brain injuries from trauma, bleeding, or aneurysm. Researchers will measure blood markers of oxidative and nitrosative stress—chemical imbalances that may harm brain cells—during the early phase after injury. They will track how these markers…

This study investigates whether people with late-onset Pompe disease have a higher risk of severe blood vessel problems in the brain and aorta. Researchers will collect medical and genetic data from adults with Pompe disease and from those who have had a brain aneurysm or bleedin…

This study tests a tablet- and smartphone-based system designed to help ICU staff decide when and how to safely start moving patients with severe brain injuries. The system checks safety factors and suggests mobility levels, from simple stretches to walking. Researchers will see …

This study looked at hormone levels in 26 people within 48 hours of a brain bleed from a burst aneurysm. Researchers checked cortisol and thyroid hormones and did a stimulation test to see if the pituitary gland was working properly. They then tracked complications like rebleedin…

This completed study looked at 114 adults with a type of brain bleed called subarachnoid hemorrhage from a ruptured aneurysm. Researchers measured the optic nerve sheath on early CT scans to see if the size could predict whether a patient would survive for 6 months. The goal was …

This small pilot study tested whether a non-invasive eye scan called OCTA can detect changes in the brain related to stroke and other neurological conditions. Researchers compared eye scans from 7 people with brain diseases and healthy volunteers. The goal was to gather early dat…

This pilot study tested a new rehabilitation approach called early motor-cognitive integrative training (e-MCIT) in 6 patients recovering from a brain aneurysm bleed. The training combines thinking exercises with physical movement in 30-minute sessions, done 4-5 times a week unti…

This study tested whether a special PET scan can predict delayed brain damage in people who had a bleeding stroke from a burst aneurysm. 35 participants received a PET scan within days of their stroke to measure how their brain cells take up sugar, which reflects blood flow. The …

This study observed how breathing machines (mechanical ventilation) are used in 2,299 brain-injured patients in intensive care units worldwide. Researchers collected data on different ventilation strategies and their link to patient recovery. No new treatments were tested; the go…

This study looked at 208 adults with severe brain injuries from bleeding or trauma. Researchers used a special monitor to track brain temperature and pressure together. The goal was to see if certain patterns could predict how well patients would recover 30 days later.

This study looked at whether doctors, nurses, or standard risk scores are better at predicting long-term recovery after a brain hemorrhage. Over 1,000 patients were followed for 6 months. The goal is to improve how we estimate outcomes for these serious conditions.

This study aimed to better understand why some people develop delayed brain damage after a brain aneurysm rupture. Researchers measured platelet activation over time in 90 patients, comparing those with aneurysm bleeds to those with other types of brain bleeds. The goal was to cl…

This study looked at how different types of exercise (interval vs. continuous) and intensity levels (moderate vs. high) affect aerobic fitness and blood vessel health in people who have had a stroke. 59 participants used a seated stepper that moves both arms and legs. The goal wa…

This study tested whether implanting special electrodes on the brain's surface can safely detect spreading depolarizations—electrical waves that may signal new damage after severe head trauma or brain hemorrhage. Twenty patients in intensive care received these electrodes alongsi…

This study looked back at data from 50 patients with severe brain injuries (from trauma or bleeding) who were treated in the ICU. Researchers analyzed brain blood flow, oxygen levels, and scans to understand how treatments affect the brain and body. The goal is to develop more pe…

This study looked at 366 people who had a brain bleed from a burst aneurysm. Researchers measured hemoglobin in the fluid around the brain and spine to see if it could predict secondary brain injury, like artery spasms or lack of blood flow. The goal is to find a better way to mo…

This study aimed to find genetic markers that could predict which patients will develop vasospasm—a dangerous narrowing of brain arteries—after a bleeding brain aneurysm. Researchers collected blood samples daily from 89 patients for 12 days to analyze their DNA and RNA. The goal…

This study followed 364 adults with severe stroke who needed a breathing machine in the ICU. Researchers measured their recovery and disability levels at 3 months and 1 year after ICU admission. The goal was to better understand what happens to these patients over time, not to te…

Researchers studied 354 adults who came to the emergency room with a brain aneurysm rupture. They looked at a specific measurement from a standard ECG, called the frontal QRS/T angle, to see if it could predict who would die within 28 days or have lasting brain damage. The goal w…

This study gathered brain monitoring data from 162 patients with serious brain injuries, such as traumatic brain injury or stroke. Using a noninvasive ultrasound device, researchers recorded blood flow signals to build a database. The goal is to develop algorithms that could one …

This study tested whether it is safe to get patients with severe brain injuries out of bed early in the intensive care unit. 22 patients were moved using a special device called the Sara Combilizer, and researchers measured brain oxygen levels and other vital signs. The goal was …