Could a liver drug protect the brain after a bleeding stroke?

NCT ID NCT01095731

Completed Disease control Sponsor: E. Sander Connolly Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether tiopronin, a drug used for liver disease, can lower a harmful chemical in the brain and improve recovery after a bleeding stroke from a burst aneurysm. Sixty patients received either tiopronin or a placebo for up to 14 days. The goal was to see if the drug is safe and reduces brain damage.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tiopronin
What this could lead to: If it works, this could point toward a treatment that reduces brain damage after a bleeding stroke.
What could go wrong: This is an early phase 2 trial with only 60 participants, so results may not apply to everyone. The drug may not improve recovery or could cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acquired aneurysmal subarachnoid hemorrhage Aneurysm brain ischemia Hemorrhage subarachnoid hemorrhage

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANEURYSMAL SUBARACHNOID HEMORRHAGE

Contacts and locations

Locations

Columbia University Medical Center

New York, New York, 10032, United States
University of Florida

Gainesville, Florida, 32611, United States
University of Washington

Seattle, Washington, 96104, United States

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