Antiplatelet drug ticagrelor tested to prevent stroke after brain bleed
NCT ID NCT07821008
First seen Sep 15, 2026 · Last updated Sep 16, 2026 · Updated 1 time
Summary
This trial tests whether ticagrelor, an antiplatelet drug, can prevent stroke and delayed brain ischemia in people who have had a low-grade aneurysmal subarachnoid hemorrhage. Participants receive either ticagrelor or a placebo for 14 days, starting just before endovascular treatment to repair the aneurysm. Researchers will track blood clots during the procedure and neurological worsening from delayed ischemia. The study aims to see if ticagrelor reduces these complications.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- ticagrelor, an antiplatelet drug
- What this could lead to
- If ticagrelor works, it could offer a way to prevent stroke and delayed brain ischemia after a brain aneurysm bleed, improving recovery for survivors.
- What could go wrong
- Ticagrelor carries a risk of bleeding, which is a concern after a recent brain bleed. The trial may show no benefit or the results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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About 274 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Sep 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2029
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age 18 - 80 years old * Low grade aneurysmal subarachnoid hemorrhage defined by a WFNS 1-3 * Aneurysmal treatment planned to be completed within 72 h after rupture * Sacciform aneurysm diameter ≥ 4 mm * Ruptured aneurysm treatable by endovascular, endo-saccular technic (stent and flow diverters are not allowed). If the aneurysm responsible of the SAH is difficult to identify, several aneurysms that may be related to the SAH can be treated during the procedure. * Affiliated person or beneficiary of a social security scheme. * Free, informed and written consent signed by the participant or truthworthy/proxy representative and the investigator (at the latest on the day of inclusion and before any examination required by the research). Exclusion Criteria: * Poor grade aSAH defined as WFNS 4 and 5 * Fusiform, dissecting, thrombosed aneurysms and aneurysm associated with brain arteriovenous malformation * Associated unruptured aneurysm requiring treatment within 3 months * History of intracranial hemorrhage within the past 6 months * Intraparenchymal hematoma associated with SAH -Ongoing antiplatelet drug * Acute symptomatic hydrocephalus or ventricular derivation * Intra-ventricular hemorrhage on admission CT scan, filling \>50% of both lateral ventricles and 3rd and 4th ventricles * Pre aSAH mRS ≥ * Active pathological bleeding and notably recent extra cranial hemorrhage (within previous 30 days), gastrointestinal hemorrhage within the past 6 months, or major surgery within 30 days * Other contra-indications to Ticagrelor: hypersensitivity to the active substance or to any of the excipients, * Severe hepatic or kidney failure, * Concomitant administration of strong CYP3A4 inhibitors(for ex ketoconazole, clarithromycine, nefazodone, ritonavir and atazanavir) drugs that interfered with P-glycoprotein transporter * Respiratory failure, asthma , obstructive broncho-pneumopathy * Pregnant and breastfeeding women * Patients under guardianship or other legal protection, deprived of their liberty by judicial or administrative decision
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
7 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Bretonneau Hospital - Tours Regional University Hospital
Tours, 37 000, France
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Fondation Adolphe de Rothschild Hospital
Paris, 75 019, France
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GH Pellegrin
Bordeaux, 33 000, France
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Gui de Chauliac Hospital - Montpellier University Hospital
Montpellier, 34 295, France
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Hautepierre Hospital - Strasbourg Hospital University
Strasbourg, 67 200, France
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Nord Laennec Hospital - Nantes University Hospital
Nantes, 44 800, France
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Pierre Paul Riquet Hospital - Toulouse University Hospital
Toulouse, 31 300, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a stronger blood thinner protect the brain after a ruptured aneurysm?
- Can a forehead light sensor spot hidden brain oxygen drops during carotid surgery?
- Can lifestyle choices after a stroke extend life and prevent a second one?
- Can blood markers predict brain injury outcomes?
- Rural doctor + telemedicine: a new way to cut stroke risk in seniors?
- Could a heart drug save brains after a burst aneurysm?