Antiplatelet drug ticagrelor tested to prevent stroke after brain bleed

NCT ID NCT07821008

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

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Status unknown
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First seen Sep 15, 2026 · Last updated Sep 16, 2026 · Updated 1 time

Summary

This trial tests whether ticagrelor, an antiplatelet drug, can prevent stroke and delayed brain ischemia in people who have had a low-grade aneurysmal subarachnoid hemorrhage. Participants receive either ticagrelor or a placebo for 14 days, starting just before endovascular treatment to repair the aneurysm. Researchers will track blood clots during the procedure and neurological worsening from delayed ischemia. The study aims to see if ticagrelor reduces these complications.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ticagrelor, an antiplatelet drug
What this could lead to
If ticagrelor works, it could offer a way to prevent stroke and delayed brain ischemia after a brain aneurysm bleed, improving recovery for survivors.
What could go wrong
Ticagrelor carries a risk of bleeding, which is a concern after a recent brain bleed. The trial may show no benefit or the results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 274 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Dec 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 - 80 years old * Low grade aneurysmal subarachnoid hemorrhage defined by a WFNS 1-3 * Aneurysmal treatment planned to be completed within 72 h after rupture * Sacciform aneurysm diameter ≥ 4 mm * Ruptured aneurysm treatable by endovascular, endo-saccular technic (stent and flow diverters are not allowed). If the aneurysm responsible of the SAH is difficult to identify, several aneurysms that may be related to the SAH can be treated during the procedure. * Affiliated person or beneficiary of a social security scheme. * Free, informed and written consent signed by the participant or truthworthy/proxy representative and the investigator (at the latest on the day of inclusion and before any examination required by the research). Exclusion Criteria: * Poor grade aSAH defined as WFNS 4 and 5 * Fusiform, dissecting, thrombosed aneurysms and aneurysm associated with brain arteriovenous malformation * Associated unruptured aneurysm requiring treatment within 3 months * History of intracranial hemorrhage within the past 6 months * Intraparenchymal hematoma associated with SAH -Ongoing antiplatelet drug * Acute symptomatic hydrocephalus or ventricular derivation * Intra-ventricular hemorrhage on admission CT scan, filling \>50% of both lateral ventricles and 3rd and 4th ventricles * Pre aSAH mRS ≥ * Active pathological bleeding and notably recent extra cranial hemorrhage (within previous 30 days), gastrointestinal hemorrhage within the past 6 months, or major surgery within 30 days * Other contra-indications to Ticagrelor: hypersensitivity to the active substance or to any of the excipients, * Severe hepatic or kidney failure, * Concomitant administration of strong CYP3A4 inhibitors(for ex ketoconazole, clarithromycine, nefazodone, ritonavir and atazanavir) drugs that interfered with P-glycoprotein transporter * Respiratory failure, asthma , obstructive broncho-pneumopathy * Pregnant and breastfeeding women * Patients under guardianship or other legal protection, deprived of their liberty by judicial or administrative decision

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    7 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Bretonneau Hospital - Tours Regional University Hospital

    Tours, 37 000, France

  • Fondation Adolphe de Rothschild Hospital

    Paris, 75 019, France

  • GH Pellegrin

    Bordeaux, 33 000, France

  • Gui de Chauliac Hospital - Montpellier University Hospital

    Montpellier, 34 295, France

  • Hautepierre Hospital - Strasbourg Hospital University

    Strasbourg, 67 200, France

  • Nord Laennec Hospital - Nantes University Hospital

    Nantes, 44 800, France

  • Pierre Paul Riquet Hospital - Toulouse University Hospital

    Toulouse, 31 300, France

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