Sleep apnea syndrome

This study tests whether combining a nerve-stimulating implant with two medications (atomoxetine and oxybutynin) can improve breathing during sleep more than either treatment alone. Twenty-four adults with obstructive sleep apnea who already have the implant will try each combina…

This trial tests whether removing the tonsils at the same time as implanting a hypoglossal nerve stimulator improves treatment for obstructive sleep apnea in adults whose airway collapses from the side during sleep. Participants are randomly assigned to receive the nerve stimulat…

This trial tests whether a combination of two sleep medications, eszopiclone and lemborexant, can help people who have both obstructive sleep apnea and insomnia. The idea is that these drugs may raise the brain's threshold for waking up, allowing more stable breathing during slee…

This study tests whether a program that includes remote monitoring, couple therapy, and peer support can help African American patients with sleep apnea use their CPAP machine more consistently. The goal is to improve sleep and quality of life for both the patient and their bed p…

This study tests whether oxygen, acetazolamide, or finasteride can help treat sleep apnea in people aged 60 and older. Researchers will measure how these treatments affect breathing stability during sleep. The goal is to find better, more personalized options for elderly veterans…

This early-phase trial is testing whether dronabinol, a synthetic form of THC, can reduce the severity of obstructive sleep apnea. 120 adults with moderate to severe sleep apnea will take the drug for two weeks. Sleep studies before and after treatment will measure changes in bre…

This study investigates whether oxygen and the drug acetazolamide can help stabilize breathing during sleep in people who take prescription opioids and have sleep apnea. Researchers will measure breathing patterns and sleep quality in 150 veterans. The goal is to find new ways to…

This study looks at whether using a CPAP machine for sleep apnea after a heart procedure (catheter ablation) can help prevent atrial fibrillation from coming back. About 658 adults with both conditions will be randomly assigned to use CPAP for a year or receive usual care. The go…

This study looks at whether using a positive airway pressure (PAP) machine at night can improve thinking, sleepiness, and quality of life in older veterans (age 60+) who have both COPD and obstructive sleep apnea—a combination called Overlap Syndrome. About 668 participants will …

This study tests whether removing the tonsils and adenoids can slow or stop the progression of scoliosis (curved spine) in children aged 6 to 15 who also have mild sleep-disordered breathing. Half of the 160 participants will have surgery within 4 weeks, while the other half will…

This study tests a jaw surgery called maxillomandibular advancement for people with moderate to severe obstructive sleep apnea who cannot use standard treatments like CPAP machines. The surgery moves the jaw forward to open the airway, and researchers will track breathing, sleepi…

This early study tests a new device called MAGNAP for people with moderate to severe obstructive sleep apnea who cannot tolerate CPAP machines. The device is surgically implanted in the neck and works with an external magnetic brace to keep the airway open during sleep. The study…

This study tests a device called the Lunair Alpha System, a neurostimulator implant that aims to treat moderate to severe sleep disordered breathing. It is for people who cannot use or do not tolerate other treatments like CPAP machines. The trial will check if the device is safe…

This study tests whether telehealth care, including a human sleep navigator, works as well as private sector care for obstructive sleep apnea in 160 military members aged 18-64. Participants will receive education, support, and troubleshooting via telehealth. The goal is to see i…

This study is testing a new implantable device called the Remede Dual Channel System for people with severe sleep apnea. The device is designed to stimulate nerves to keep the airway open during sleep. Researchers will check if the implant is safe and if it can reduce breathing p…

This study looks at whether screening for and treating sleep apnea can reduce the burden of atrial fibrillation (AFib) in patients who are candidates for heart ablation. Fifty adults with paroxysmal or persistent AFib that hasn't responded to medication will be screened for sleep…

This registry follows 225 adults with moderate-to-severe obstructive sleep apnea who receive the Inspire hypoglossal nerve stimulation implant. The device is for people who cannot use CPAP, the standard treatment. Researchers will measure how well it reduces breathing pauses duri…

This registry follows 1,000 people with obstructive sleep apnea who have received the Inspire implant, a device that stimulates nerves to keep the airway open during sleep. Researchers will track how well the device works over time and how consistently patients use it, using rout…

This trial evaluates a new chest patch sensor designed to monitor breathing movements and sleep position, which could improve the diagnosis of sleep apnea. The sensor aims to provide additional information beyond current fingertip sensors, potentially helping to distinguish betwe…

This study investigates whether tiny molecules in the blood, called microRNAs, can serve as biomarkers for obstructive sleep apnea (OSA). Researchers will compare blood samples from people with moderate-to-severe OSA and those without the condition, before and after treatment wit…

This study aims to see if a French version of the OSA-18 questionnaire can accurately identify obstructive sleep apnea in children. Parents of children aged 4 to 17 who are already scheduled for a sleep test (polysomnography) will fill out the questionnaire. The results will be c…

This study looks at whether a simple questionnaire given during a dental checkup can identify children at risk for sleep-disordered breathing (like sleep apnea). Sixty children aged 8-13 will fill out the questionnaire and then wear a home sleep monitor for one night to measure t…

This study looks at whether a home sleep apnea test is as accurate as the standard overnight sleep lab test for children ages 5 to 12. Researchers will compare results from both tests and see how they affect treatment choices. The goal is to find a more comfortable and convenient…

This study is testing whether a portable sleep monitor can accurately detect obstructive sleep apnea in children with autism spectrum disorder. Twenty children aged 6 to 18 will wear the portable device at the same time as their standard in-hospital sleep test. Researchers will c…

This study tests a wearable device called Sunrise that tracks small jaw movements during sleep to diagnose obstructive sleep apnea (OSA). About 100 adults referred to a sleep clinic will use Sunrise alongside standard tests like oximetry or WatchPAT. Researchers want to see if Su…

This study checks if wearable devices like movement sensors, headbands, and pulse oximeters can accurately track sleep stages in children and teens aged 3 to 18. Results will be compared with standard sleep lab tests to see if these gadgets can help diagnose sleep problems more e…

This study is testing whether a smartphone app called Apneal can accurately diagnose sleep apnea in adults who already need an overnight sleep test. About 500 participants will wear the app on their chest while also undergoing standard polysomnography at home. The goal is to see …

This study tests two simple ways to prevent bite changes in people using a mouthpiece for sleep apnea or snoring. Some participants will use a special aligner each morning to gently guide their jaw back into place, while others will do daily jaw exercises. The goal is to see whic…

Researchers test whether non-invasive light therapy, called photobiomodulation, can reduce tonsil size and improve sleep apnea in children. The study enrolls 64 children with enlarged tonsils and sleep apnea symptoms. Participants receive either active or sham light therapy to th…

This study tests whether bexagliflozin, a drug used for diabetes, can reduce the severity of obstructive sleep apnea in overweight or obese adults. Over 6 months, participants will take either the drug or a placebo and undergo sleep tests and body scans. The goal is to see if the…

This study tests a special nasal airway device (ssNPA) in 40 children with weak throat muscles and obstructive sleep apnea, including those with Down syndrome. The device is designed to keep the airway open during sleep without needing surgery. Researchers will measure how well i…

This study tests whether extra support—like personalized mask fitting, monthly phone calls, and a tracking app—helps stroke patients with sleep apnea use their CPAP machine more consistently during rehab. About 250 participants will be randomly assigned to either this intensive s…

This study tests three approaches—oxygen therapy, the drug trazodone, and brief low-oxygen episodes—to see if they can improve sleep apnea in people with chronic cervical spinal cord injury. Researchers will measure changes in breathing and sleep quality in 100 participants. The …

This study tests whether a silicone mouth tape worn during sleep can reduce snoring and improve sleep quality in people with mild sleep apnea or simple snoring. About 100 adults with a bed partner will use the tape for a period, and both the snorer and partner will report on snor…

This study tests whether a sleep medication called eszopiclone can help people with obstructive sleep apnea use their CPAP machine more consistently and improve their thinking skills. About 250 adults with a new sleep apnea diagnosis will receive either eszopiclone or a placebo f…

This study looks at whether children with medical complexity (ages 5-17) can safely start using a nighttime breathing machine at home instead of in a hospital sleep lab. The machine helps them breathe better at night, improving quality of life. Researchers will compare home start…

This study tests whether a nasal spray of oxytocin, a natural hormone, can lower the air pressure needed from a CPAP machine in people with obstructive sleep apnea. Forty adults who already use CPAP will take the spray or a placebo before bed for 14 days. Researchers will measure…

This study tests whether daily treatments with slightly elevated carbon dioxide (hypercapnia) can improve breathing and reduce sleep apnea in Veterans with spinal cord injury. About 30 adults with chronic spinal cord injury or able-bodied people with sleep apnea will receive the …

This study tests whether adding a quick stitching step (lateral pharyngoplasty) to standard tonsillectomy helps children recover better. About 160 kids aged 3-17 will be randomly assigned to get tonsillectomy with or without the extra stitch. Parents will track pain, eating, and …

This study tests whether a non-invasive electrical stimulation device can help people with obstructive sleep apnoea breathe easier during sleep. Fifteen adults with moderate to severe sleep apnoea will wear sticky electrodes under their chin while sleeping. The goal is to see if …

This study compares two methods of delivering oxygen during sleep in children aged 5-17 with Down syndrome and moderate to severe obstructive sleep apnea. Ten participants will have two sleep studies—one with continuous oxygen flow and one with pulse flow from a portable concentr…

This study compares a single dose of methadone (a long-acting opioid) given during surgery to standard short-acting opioids for pain relief after tonsillectomy in children ages 3 to 17. The goal is to see if methadone reduces the need for extra pain medication in the recovery roo…

This study tests whether taking nattokinase, a supplement made from fermented soybeans, can improve sleep quality, thinking skills, and heart health in people at risk for metabolic syndrome. About 80 adults will take either the supplement or a placebo for 12 weeks, then switch af…

Researchers want to know if breathing patterns recorded while premature babies are in the neonatal intensive care unit relate to asthma, sleep-disordered breathing, and neurodevelopmental problems at preschool age. The study follows up to 500 children born before 29 weeks of preg…

This study looks at how common sleep apnea is in people hospitalized with schizophrenia and whether it affects their mental health. Researchers will use a special ring and a fiber-optic mat to track breathing during sleep without any wires or uncomfortable equipment. The goal is …

This study follows 200 adults with newly diagnosed obstructive sleep apnea who are starting CPAP therapy. Researchers measure biomarkers from the initial sleep study, including hypoxic burden, pulse wave amplitude drops, and heart rate variability. They then check whether these m…

This trial tests whether mailing a sleep apnea home-testing device to people with atrial fibrillation can improve their quality of life. About 936 participants will either receive the device and possible treatment, or no test at all. Researchers will track symptoms, activity, and…

This study checks tongue strength in 78 children with suspected obstructive sleep apnea. Researchers use a device to measure tongue pressure during pushing and swallowing. They compare results to healthy kids to see if weak tongue muscles are linked to sleep problems.

This study looks at how sleep apnea measurements change from night to night. Current tests rely on a single night, which can be inaccurate. Researchers will track 192 people over multiple nights to find more reliable markers for diagnosis and treatment.

This study looks at why central sleep apnea happens and how to treat it better. Researchers will test a combination of a drug (acetazolamide), extra oxygen, and a breathing machine (PAP therapy) in 200 veterans with this condition. The goal is to understand the body's breathing c…

This study looks at how sleep-disordered breathing (like snoring or pauses in breathing) affects blood vessel function and heart health in pregnant people. Participants complete an 8-day testing protocol at two points during their pregnancy. The goal is to understand whether slee…

This study follows 320 people with small-to-moderate thoracic aortic aneurysms for up to 5 years. Researchers will track major complications like rupture or need for surgery, and look for factors such as high blood pressure or sleep problems that might speed up aneurysm growth. T…

This study looks at sleep problems like sleep apnea and insomnia in 226 people who have had a stroke. Researchers want to see how these sleep issues affect recovery, daily activities, and quality of life. Participants will use a home sleep test and a smartwatch to track sleep and…

This study looks at how changes in brain blood flow affect breathing control during sleep in healthy adults. Researchers will expose participants to normal oxygen and low oxygen levels to see how the brain responds. The goal is to better understand sleep apnea and related conditi…

This study is following 1,000 people in Korea who have symptoms of sleep apnea, like loud snoring or feeling very tired during the day. The goal is to learn more about the condition and how well patients stick with breathing machine therapy. Participants will have sleep tests and…

This study looks at how sleep apnea changes pressure in the brain and belly during sleep in people with normal-pressure hydrocephalus. Researchers want to see if these pressure changes affect how well a surgically placed shunt (a tube that drains fluid from the brain) works. The …

This study is testing a small, wireless wearable device that tracks breathing in children. It aims to see if the device works well for kids who have trouble with standard sleep or breathing tests, including premature infants, children with sleep apnea, and those with epilepsy at …

This study watches 150 adults with heart valve problems who are getting a procedure (TAVI or M-TEER) to see if it helps their sleep-disordered breathing. Participants take a sleep test before the procedure and again 6 months later. The goal is to learn how fixing heart valves mig…

This study aims to learn more about PFAPA, a condition that causes repeated fevers, sore throats, and mouth sores in children. Researchers will collect blood, saliva, stool, and tonsil tissue from 1,500 people with PFAPA or other tonsil problems. No treatment is given; the goal i…

This study looks at 30 six-month-old infants with Down syndrome to see if their sucking patterns are linked to the severity of obstructive sleep apnea (OSA). Researchers will measure sucking bursts and compare them to sleep study results. The goal is to find a simple way to scree…

This study looks at 1,200 children and young adults (ages 1-20) with suspected sleep-disordered breathing to see if their sleep test results match up with problems in thinking, mood, and behavior. Participants will complete sleep studies, questionnaires, and thinking tests. The g…

This study looks at whether orthodontic treatments like Twin Block and Hyrax appliances can improve breathing in children aged 8-14 with small jaws and narrow upper airways. Researchers will use 3D scans to measure changes in airway shape and airflow. The goal is to understand if…

This study will follow 1,000 adults in Spain who are suspected of having obstructive sleep apnea (OSA) and daytime sleepiness. Participants will undergo standard sleep tests, blood pressure monitoring, and fill out questionnaires about their quality of life and sleepiness. Resear…

This study follows 35 people with severe obesity who are having mini-gastric bypass surgery. Researchers want to see how the surgery changes body composition and improves related health issues like type 2 diabetes, sleep apnea, high blood pressure, and fatty liver disease. The go…

This study tests a program called REPOSE, where a patient navigator helps families overcome barriers to getting specialist care for children with sleep-disordered breathing. The navigator provides support, resources, and coordinates care between doctors and parents. The goal is t…

This study tests if a special pad placed under the mattress can help doctors better adjust a mouthpiece used to treat obstructive sleep apnea. About 70 adults with sleep apnea will use the device at home while their treatment is fine-tuned. The goal is to see if the device accura…

This study looks at whether a night of disrupted sleep can lead to extra heartbeats or atrial fibrillation the next day. Researchers will ask 100 adults with sleep apnea to either use or not use their sleep device on different nights, then monitor their heart rhythms. The goal is…

This study looks at oxygen levels in adults over 65 after hip fracture surgery, comparing regional (spinal) anesthesia to general anesthesia. Researchers will measure oxygen saturation and track complications like sleep apnea, delirium, and hospital stay length. The study is obse…

This study looks at sleep quality in 100 people with atrial fibrillation (AFib) who are scheduled for a heart procedure called pulmonary vein isolation. Participants will have four non-invasive sleep tests—two before and two after the procedure—to measure breathing, heart rate, a…

Researchers at Mayo Clinic are studying 600 Somali-American adults to understand how common obstructive sleep apnea is and how it affects heart health. Participants will have sleep tests, blood pressure monitoring, and glucose testing. The goal is to learn about unique risk facto…

This study compares two ways of adjusting a nerve stimulator implant (Inspire system) for obstructive sleep apnea. Currently, patients need an overnight sleep study to fine-tune the device. Researchers want to see if a daytime sleep study works just as well. The trial will enroll…