Portal hypertension

This study is checking how well a device called the Cera Vascular Plug works and if it is safe. The plug is used to block blood flow in certain blood vessels to treat conditions like aneurysms, abnormal connections between arteries and veins, and other problems. About 132 adults …

This study compares early placement of a TIPS (a small tube that reroutes blood flow in the liver) against standard treatments like diuretics and fluid drainage in 134 patients with liver cirrhosis and ascites (fluid buildup). The goal is to see if TIPS improves survival and redu…

This study tests two drugs, terlipressin and somatostatin, to see which one better lowers high blood pressure in the liver's main vein during a living-donor liver transplant. High pressure can cause dangerous bleeding, so finding the best drug may improve safety. About 50 adults …

This study tests whether adding the blood thinner apixaban to the heart drug carvedilol can prevent complications like bleeding, fluid buildup, and confusion in people with cirrhosis and high blood pressure in the liver. About 220 adults with stable cirrhosis will take either api…

This study tests whether the blood thinner apixaban can dissolve blood clots in the portal vein that develop more than a year after laparoscopic spleen surgery in people with cirrhosis. Twenty participants will take apixaban twice daily, and doctors will use ultrasound or CT scan…

This study looks at whether the blood thinner apixaban can safely dissolve blood clots in the portal vein (the main vein to the liver) that appear more than a year after spleen removal surgery. It involves 20 adults with cirrhosis who had their spleen removed. The goal is to see …

This study tests a new surgical method that uses the vagus nerve to guide spleen removal and vein disconnection in people with cirrhosis and portal hypertension. The goal is to see if this nerve-guided approach reduces common post-surgery problems like diarrhea and delayed stomac…

This study tests whether vonoprazan, a stomach acid blocker, can prevent ulcers that often form after endoscopic variceal band ligation (EVBL) in people with liver cirrhosis. About 154 adults will take either vonoprazan or a placebo daily for 14 days after the procedure. Research…

This study tests whether a two-step procedure can help people with advanced liver disease and severe obesity. First, a TIPS procedure lowers pressure in the liver veins. Then, sleeve gastrectomy surgery helps with weight loss. The study compares this approach to standard medical …

This study tests a special stent called LIVERTY TIPS, placed in the liver to create a new pathway for blood flow in people with cirrhosis and high blood pressure in the liver. The goal is to see if it can keep the new channel open and reduce problems like bleeding or fluid buildu…

This study looks at whether adding branched-chain amino acid (BCAA) supplements to a standard liver procedure (TIPS) can help reverse muscle loss (sarcopenia) in people with cirrhosis and high blood pressure in the liver. About 164 patients will be randomly assigned to receive ei…

This study tests whether carvedilol, a beta-blocker, can reduce high blood pressure in the liver's portal vein in people with cirrhosis. High pressure can lead to dangerous bleeding. Researchers will use an endoscopic ultrasound to measure pressure before and after one month of t…

This study tests whether a special ultrasound technique (SHAPE) can detect high blood pressure in the liver without using a needle. Portal hypertension is a serious condition that can lead to severe liver damage and death. The standard test requires inserting a catheter into a ve…

This study tests a new method using an endoscope with ultrasound to measure pressure in the liver's blood vessels. It aims to see if this technique is safe and can predict complications like bleeding in 30 patients with cirrhosis from chronic hepatitis. The procedure is done duri…

This study is testing whether a special MRI scan called 3D-MRE can accurately detect high blood pressure in the liver (portal hypertension) caused by cirrhosis or advanced liver disease. Currently, doctors use an invasive catheter procedure (HVPG) to measure this pressure. The st…

This study tests whether a 3D MRI scan (3D-MRE) is better than a standard 2D MRI scan at detecting liver scarring (cirrhosis) and high blood pressure in the liver (portal hypertension). Researchers will compare both scans to the current gold-standard catheter measurement in 100 a…

This study is testing whether a non-invasive ultrasound of the spleen can accurately detect dangerous vein swelling and high blood pressure in the liver. Researchers will enroll 450 adults with advanced chronic liver disease. If successful, this simple scan could replace the curr…

This study aims to improve how doctors see liver damage (cirrhosis), liver cancer, and high blood pressure in the liver using a special PET/MRI scan. About 45 adults with cirrhosis will get this scan to see if it gives clearer pictures than current methods. The goal is to make di…

This study is testing a blood test called hepatomiR to see if it can predict when people with chronic liver disease will develop serious complications like fluid buildup in the belly, bleeding from the esophagus, or confusion from liver failure. Researchers will follow 156 outpat…

This pilot study tests whether taking melatonin at night can increase REM sleep and improve cognitive function in people with cirrhosis who have a complication called hepatic encephalopathy (HE). Participants take melatonin for one month and a control supplement (thiamine) for an…

This study is observing 400 people aged 12 and older who have noncirrhotic portal hypertension (NCPH) or are at risk for it. NCPH is a liver condition that increases blood pressure in the liver's blood vessels without causing cirrhosis, and often has no early symptoms. Researcher…

This study tests whether a special ultrasound done through an endoscope can measure how well beta-blockers are working in people with cirrhosis and high blood pressure in the liver. Twenty-four participants will get the ultrasound before and after three months of treatment with c…

This study is a registry that will follow 500 people with primary biliary cholangitis (PBC) in Austria. Researchers will collect medical data and optional blood or liver samples to learn how the disease progresses and what complications arise. No new treatment is being tested; th…

This study will check for microplastics in liver tissue from 30 people with cirrhosis who are having surgery or a liver transplant. Researchers want to see if these tiny plastic particles are linked to worse liver damage, higher blood pressure in the liver, and heart problems. Th…

This study looks at people with high blood pressure in the liver that causes swollen veins in the esophagus and stomach. Researchers will compare those who get an endoscopic procedure (using a camera down the throat) with those who receive other treatments like medicine or surger…

This study follows 2000 people with severe liver-related high blood pressure who receive a TIPS procedure, which creates a bypass in the liver. Researchers will track survival, need for liver transplant, and complications like confusion or liver failure over 12 months. The goal i…

This study looks at how blood clotting works differently in the liver's portal vein compared to the rest of the body in people with liver cirrhosis. Researchers will take blood samples from 45 patients during a routine procedure called TIPS, which helps relieve high blood pressur…

This study looks at factors that help blood clots in the main liver vein dissolve in people with liver scarring (cirrhosis) and enlarged stomach veins. Researchers will follow 1,500 patients over time to see what influences clot recovery. The goal is to help doctors and patients …

This study compares two methods for measuring blood pressure in the liver (portal hypertension) in people with cirrhosis or other liver conditions. The standard method (HVPG) uses a catheter inserted through a neck vein, while the newer method (EUS-PPG) uses an endoscope passed t…

This study is creating a large collection of medical data and biological samples from 1000 people with portal hypertension, a condition that can cause dangerous bleeding in the esophagus or stomach. The goal is to use advanced technologies like genetics and imaging to better unde…

This study looks at whether handgrip strength—a simple measure of muscle function—can help predict changes in blood flow through the liver's main vein in people with cirrhosis. Researchers will measure blood pressure and flow in the portal vein and nearby veins before and after a…

This study looks at 600 adults with liver cirrhosis to see if a shorter MRI scan works better than ultrasound for finding early liver cancer. Researchers will also track body composition and other health changes over time. The goal is to improve how doctors monitor and predict li…

This study looks at a rare liver condition called Porto-Sinusoidal Vascular Disease (PSVD), which causes high blood pressure in the liver's veins. Researchers want to see if a procedure called TIPS works as well for PSVD patients as it does for those with cirrhosis. They will com…

This study follows 10,000 people with advanced chronic liver disease at Vienna General Hospital. Researchers will track their health over time, collect blood, urine, and tissue samples, and record complications like bleeding or liver failure. The goal is to better understand how …

This registry follows 250 patients with decompensated liver cirrhosis who receive a TIPS procedure, a shunt placed in the liver to reduce pressure. Researchers will track survival, brain function, nutrition, and quality of life over one year. The goal is to identify which patient…