Portal hypertension

This trial compares two approved treatments for ascites (fluid buildup in the belly) caused by portal hypertension. One group receives large-volume paracentesis (draining fluid with a needle) plus albumin infusion, while the other gets an early TIPS procedure, which creates a new…

This study looked at whether giving antibiotics before an endoscopic procedure helps prevent fever and rebleeding in people with cirrhosis who have had variceal bleeding before. 226 patients were randomly assigned to receive the antibiotic ceftriaxone or no antibiotics before the…

This study tested a new robotic surgery technique that protects the vagus nerve during spleen removal and blood vessel disconnection in 60 cirrhosis patients with portal hypertension. The goal was to see if it reduces common side effects like diarrhea and delayed stomach emptying…

This study tested whether a computer program (Simcyp) could predict the right doses of two blood pressure drugs, nebivolol and carvedilol, for people with liver cirrhosis and high blood pressure. Forty patients were randomly assigned to one of the two drugs and monitored for thre…

This study looked at two types of stents used in a procedure called TIPS, which creates a bypass in the liver to relieve complications of cirrhosis. One stent is covered with a special material to stay open longer but costs more; the other is a standard bare stent that is cheaper…

This study tests whether the inferior vena cava (the body's main vein) can serve as a reliable reference point for measuring blood pressure in the liver during an endoscopic ultrasound. Normally, doctors use a hepatic vein for this, but in people with advanced liver scarring, tho…

This study tested whether a noninvasive device called FibroScan can accurately measure liver scarring (fibrosis) in children, potentially replacing the need for a liver biopsy. Researchers compared FibroScan results with biopsy results in 264 children aged 6 months to 18 years wi…

This completed Phase 3 trial tested whether a combination of lactulose (a medicine) and virtual Tai-Chi (a gentle exercise) could reduce falls and other serious events in 230 people with cirrhosis and portal hypertension. Participants were randomly assigned to different sequences…

This study looked at placing a small metal tube (stent) into the portal vein of 63 cancer patients whose vein was blocked by a tumor. The goal was to relieve serious symptoms like fluid buildup in the belly or bleeding in the gut. The procedure was done through a needle in the li…

This completed Phase 1 study looked at 27 people with and without pulmonary hypertension to learn more about how blood vessel problems contribute to the disease. Researchers used heart catheterization, imaging, and blood tests to find biomarkers and understand disease mechanisms.…

This study compared two procedures for getting a liver biopsy and measuring liver pressure in people with chronic liver disease or cirrhosis. One method uses a scope through the mouth (endoscopic ultrasound), the other goes through a vein in the neck (transjugular). The goal was …

This study looked at 82 adults with cirrhosis and portal hypertension (high blood pressure in the liver) to find out how many have minimal hepatic encephalopathy (MHE) — a mild form of brain fog that can affect thinking. Researchers used simple blood tests and thinking exercises …

This study tested whether a computer program could help doctors choose the right dose of simvastatin for people with cirrhosis and high blood pressure in the liver. Twenty-two patients received either 5 mg or 15 mg of simvastatin daily for three months. Researchers measured chang…