Penile disorder

This early-stage trial is testing an experimental drug called EVOLVE104 in people with advanced bladder cancer or several types of squamous cell carcinoma (lung, esophagus, skin, and others). The study aims to find a safe dose and see if the drug can shrink tumors. It is for pati…

This phase II trial is testing whether a combination of three drugs—cabozantinib, nivolumab, and ipilimumab—can shrink or slow the growth of rare genitourinary cancers that have spread. About 314 adults with these uncommon tumors will receive the drugs. The goal is to see if the …

This phase 2 trial tests whether the drug sacituzumab govitecan, alone or combined with atezolizumab, can shrink rare tumors of the kidney, bladder, ureters, or penis. About 60 adults with specific rare cancer types will receive the drugs intravenously in 21-day cycles. The study…

This study tests a combination of two drugs, enfortumab vedotin and avelumab, as a first treatment for men with advanced or metastatic penile cancer that cannot be cured by surgery. The goal is to see if the drugs shrink tumors and help patients live longer. About 25 men will tak…

This study tests whether a single infusion of a patient's own genetically engineered immune cells (E7 TCR-T cells) can shrink or eliminate HPV-related cancers before the patient receives standard treatment like chemo-radiation or surgery. The trial enrolls 15 adults with advanced…

This study tests a new immunotherapy for people with advanced HPV-related cancers, such as cervical, throat, anal, and penile cancers. Participants receive specially engineered immune cells designed to attack cancer cells carrying the HPV16 virus. The goal is to see if this treat…

This study tests a drug called enfortumab vedotin for people with penile cancer that has spread or cannot be removed by surgery. The drug works like a smart bomb, targeting a protein on cancer cells to deliver a toxin that kills them. About 28 adults will take part to see if the …

This study tests whether taking sildenafil (a drug for erectile dysfunction) daily for 10 months, starting 30 days after surgery, can prevent long-term erectile problems in men treated for rectal cancer with radiation and surgery. The trial includes 188 men aged 18 to 70 who had …

This study tests two drugs, QL1706 and lenvatinib, in people with advanced penile cancer that has already been treated. The goal is to shrink tumors and possibly make them removable by surgery. About 47 adults aged 18–80 will receive the drugs for up to a year, with the aim of co…

This study tests whether robot-assisted groin lymph node removal causes fewer serious side effects than standard open surgery in 80 men with penile cancer. The goal is to reduce wound healing problems and other complications while still effectively controlling the cancer. Partici…

This study tests the drug nivolumab in people with advanced rare cancers that have a specific marker (PD-L1). The goal is to see if the drug can shrink or control the tumors when other treatments have stopped working. Up to 28 adults will receive treatment for up to 12 months, an…

This early-phase trial tests a new two-drug combination (MRG003 and HX008) as a first treatment for advanced penile cancer that has spread. It aims to be more effective and less toxic than standard chemotherapy. The study enrolls 10 men with a specific type of cancer (EGFR-positi…

This study tests whether injecting stem cells or their exosomes into the penis can improve erectile function in men with diabetes who haven't been helped by standard treatments. Ninety men will receive either a placebo, stem cells, or exosomes in a single injection. Researchers w…

This study compares two surgical techniques for men with complex Peyronie's disease, a condition causing painful penile curvature. Researchers will test whether a newer, microsurgery-based method (subtunical microdissection) works better than the standard plaque incision and graf…

This study is testing a new implantable device that delivers electrical pulses to nerves to help men get erections after prostate removal for cancer. Twenty men aged 30-70 who are already scheduled for nerve-sparing prostatectomy will either get the device or not. Researchers wil…

This study looks at whether two common statins (pitavastatin and rosuvastatin) affect male sex hormones and erectile function in men aged 40-65 with high heart risk. Researchers will monitor 150 men for 6 months, checking hormone levels, erectile function, and blood vessel health…

This study tests a surgical technique that grafts nerves to help men who have had lasting erectile dysfunction (ED) for over 18 months after prostate cancer surgery. About 100 men will receive the procedure and be followed for one year to see if their erections improve and if the…

This study tests a precise type of radiation therapy (MRgRT) that aims to protect the nerves and blood vessels needed for erections in 70 men with low- or intermediate-risk prostate cancer. Participants receive 5 high-dose radiation sessions guided by MRI. The goal is to see if t…

This study is testing a new inflatable penile implant called Rigicon Infla10 for men with erectile dysfunction. About 182 men will receive the implant and be followed for up to 3 years to see if it is safe and works well. The main goal is to check for serious side effects and whe…

This study is a safety follow-up for 32 men who previously received an experimental stem cell treatment (Cellgram-ED) for erectile dysfunction after prostate removal due to cancer. Researchers are monitoring tumor markers, serious side effects, and any cancer recurrence over time…

This study looks at whether adding regular exercise (treadmill walking) to vitamin D supplements can improve erectile function in men with type 2 diabetes who also have low vitamin D. Forty men will take vitamin D every two weeks for 12 weeks; half will also walk three times a we…

This study tests whether adding low-intensity shockwave therapy to standard Xiaflex injections can better reduce penile curvature in men with Peyronie's disease. Sixty participants will receive both treatments or Xiaflex alone. The goal is to improve sexual function and reduce bo…

This phase 2 trial tests whether giving pembrolizumab (Keytruda) plus chemotherapy (carboplatin and paclitaxel) before surgery can completely eliminate advanced penile cancer in the penis and lymph nodes. About 27 men with resectable, node-positive penile cancer will receive the …

This study is testing a new inflatable penile implant called the Rigicon Infla10 for men with erectile dysfunction. Researchers will implant the device in 182 men and follow them for up to 3 years to see if it is safe and works well. The main goal is to check if the implant helps…

This study tests whether combining two drugs, dostarlimab and niraparib, can shrink tumors or slow the growth of advanced penile cancer in patients whose cancer has worsened after chemotherapy. About 25 adults with stage III or IV penile cancer will receive the combination treatm…

This early study tests a new implantable device that stimulates nerves to help men recover natural erections after prostate cancer surgery. Twenty men aged 30-75 will receive the device during their prostate removal and be followed for 6 months. The main goals are to check if the…

This study tests two experimental drugs, SI-B003 alone or combined with BL-B01D1, in people with advanced bladder cancer or other solid tumors that have not responded to standard treatments. The goal is to see if these drugs can shrink tumors or slow disease progression. About 52…

This study tests whether a natural supplement called L-citrulline can improve mild to moderate erectile dysfunction as well as the standard drug tadalafil (Cialis), and whether taking both together works even better. About 133 men aged 30-70 will take one of three treatments dail…

This study tests three pelvic floor treatments in 150 men with lifelong premature ejaculation: electromagnetic stimulation, biofeedback training, and standard exercises. The goal is to see which best increases ejaculation time and improves control. Participants will be treated fo…

This study tests whether applying a powder called ARISTA AH during robotic prostate removal can reduce blood loss and help preserve erectile function. About 362 men with prostate cancer will be randomly assigned to receive the powder or standard care. The goal is to see if the po…

This study tests a new gel called ST-04 that is placed inside the urethra (the tube in the penis) to help men with erectile dysfunction (ED) who haven't had success with standard pills. The gel contains a medicine that widens blood vessels to produce an erection. About 83 men wil…

This study looks at whether saving a small extra artery to the penis during robotic prostate cancer surgery can help men recover erections. About 1 in 3 men have this artery, and the study will use MRI scans to find it before surgery. Researchers will follow 20-40 men for a year …

This study tests whether a guided journaling program can reduce anxiety in parents of children with urogenital conditions like differences of sex development (DSD) or hypospadias. Twenty parents will complete five writing prompts over several weeks and then share their experience…

This study tests a device that delivers gentle shockwaves to the penis to help men with erectile dysfunction (ED). Researchers want to find out which patients see real improvement after treatment. About 157 men with ED will receive the therapy and be followed for 3 months. The go…

This study compares two methods to help men regain erectile function after prostate cancer surgery. About 224 men who had surgery within the past 9 months will take part. The goal is to see which approach works better for sexual rehabilitation.

This study tests whether a mobile app with educational videos, pelvic floor exercises, and reminders can improve recovery of bladder control and erectile function in men after prostate cancer surgery. About 78 men scheduled for prostate removal will be randomly assigned to either…

This study tests whether an 8-week pelvic floor exercise program can improve erectile dysfunction and premature ejaculation in men aged 25-45. Half of the 50 participants will do the exercises three times a week, while the other half receives standard medical care. The goal is to…

This study tests a device called VERTICA® that uses radio frequency energy to treat erectile dysfunction (ED). About 98 men with mild to moderate ED will use the device at home for 6 months, either the real device or a sham version. The goal is to see if the device improves erect…

This study tests whether taking a daily low-dose tadalafil plus an on-demand higher-dose sildenafil works better than on-demand sildenafil alone for men with erectile dysfunction who haven't responded to standard treatments. About 500 men will take the combo or a placebo for 12 w…

This study compares how a single plant-based meat meal (a Beyond Meat product) versus an animal meat meal affects erectile function in 30 healthy men with normal erections. Participants eat one meal and then wear a Rigiscan device overnight to measure erection hardness and freque…

This study is testing whether pelvic floor therapy—a mix of exercises, biofeedback, and mild electrical stimulation—can help men with erectile dysfunction and/or premature ejaculation. Sixty-six men will be split into three groups based on their condition and will receive the the…

This study tests if focused or radial shockwave therapy can improve erectile dysfunction and chronic pelvic pain better than a fake (sham) treatment. It includes 186 men, some with a history of prostate cancer. Participants will receive several sessions of shockwave or sham thera…

This study is testing whether extracorporeal shockwave therapy can help men with stable Peyronie's disease. The treatment uses sound waves applied to the penis to target scar tissue. Researchers will measure changes in erectile function and quality of life in 50 participants over…

This pilot study tests a non-invasive 3D-printed external device to help men with erectile dysfunction achieve satisfactory sexual intercourse. Nine men with moderate to severe ED from any cause, along with their female partners, will try the device. The goal is to see if it is s…

This study tests whether 4-aminopyridine (4-AP) can help men recover faster from nerve damage caused during prostate cancer surgery. About 70 men aged 45-75 with early-stage prostate cancer will take the drug or a placebo after their operation. The goal is to see if it improves b…

This study tests whether adding aerobic exercise (like walking on a treadmill) to cognitive behavioral therapy can improve erectile function in heavy drinking men who also have metabolic syndrome and impotence. Forty men will be split into two groups: one gets only talk therapy, …

This study tests whether the BTL Emsella Chair, a device that uses electromagnetic energy, can help men with sexual dysfunction, including erectile and ejaculatory problems. The trial has two phases: first, a small pilot study where all 10 men get active treatment, followed by a …

This early-stage study tests whether taking a new liquid form of sildenafil (Hezkue Turbo®) with food changes how the body absorbs it compared to taking it on an empty stomach. Twelve healthy men aged 20 to 70 will each receive a 100 mg dose under both conditions. The goal is to …

This phase 1 trial tests whether a fractional CO2 laser can safely reduce the scar tissue that causes penile curvature in Peyronie's disease. Sixty men with stable, chronic disease will receive three laser sessions over 18 weeks. The main goal is to check for side effects, but re…

This study tests whether using a penile traction device (RestoreX) for 3 months before getting a penile implant can increase the length of the implant and improve patient satisfaction. About 48 men with erectile dysfunction will be randomly assigned to use the device or not. The …

This study collects blood, urine, saliva, and tissue samples from nearly 6,000 people who have or may have cancer, including rare inherited forms. The samples are stored and used for research to understand the genetic and molecular basis of cancer. No new treatment is being teste…

This study is building a huge registry of information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. Researchers will use this resource to study what causes cancer and how to better prevent, detect, and treat it. The re…

This study investigates why some men have difficulty using the pump of their inflatable penile prosthesis after surgery, leading to dissatisfaction. Researchers will look at factors like age, weight, pump type, and whether patients saw a demonstration before surgery. The goal is …

This study aims to find out if chronic pelvic pain conditions like prostatitis and interstitial cystitis can be inherited. Researchers will collect DNA and urine from 500 participants, including family members, to look for genetic links. The goal is to better understand the cause…

This study follows 1,100 adults with rare urinary tract cancers, such as unusual bladder, kidney, testicular, or penile cancers. Researchers will collect medical records, blood and tumor samples, and imaging over many years to understand how these cancers grow and respond to trea…

This study asks 100 adult men to stop watching pornography for 30 days and tracks changes in nighttime erections, sexual function, and mood using a wearable device and surveys. Participants first observe their normal habits for a short period, then compare results during abstinen…

This study looks at how Traditional Medicine classifies erectile dysfunction (ED) into different patterns and how those patterns relate to a man's age, lifestyle, and mental health. Researchers will study 375 men with ED in Vietnam to better understand these connections. The goal…

This study follows 100 men aged 30-75 who had a heart procedure called PCI (stent placement) to open blocked arteries. Researchers want to see how erectile function changes over 6 months, comparing those who had a heart attack to those with stable chest pain. Participants fill ou…

This study is testing whether a simple finger device called EndoPAT can measure blood vessel function in men aged 30–50 with erectile dysfunction or low testosterone. About 120 men will use the device before and after taking daily low-dose ED medication or testosterone therapy. T…

This study is for men who have had a penile prosthesis implanted for erectile dysfunction. It aims to understand how well they can manipulate the pump, including hand strength and sensation. Researchers will also look at how these abilities relate to erection rigidity and sexual …

This study follows 400 patients who have had urologic cancer surgery with lymph node removal to see how often they develop lymphedema (leg swelling). Researchers will use questionnaires and special devices to measure swelling and tissue fluid over two years. The goal is to better…

This study looks at how plant-based meals compare to animal-based meals on erectile function in 46 healthy men with normal erections. Participants eat specially prepared meals and wear a device to measure nighttime erections. The goal is to see if diet alone can make a difference…