Penile disorder

This trial tests whether injecting platelet-rich plasma (PRP) into the penis, taking a daily oral erectile dysfunction medication (tadalafil 5 mg), or using both together can better improve erectile function in men with organic erectile dysfunction. About 75 men who have had the …

This trial tests whether injecting platelet-rich plasma (PRP) — a concentrate made from a person's own blood — into the penile plaque can reduce curvature and ease symptoms in men with Peyronie's disease. Half the participants receive PRP injections and half receive a placebo (sa…

This clinical trial investigates whether different dosing schedules of tadalafil or tamsulosin, when combined with a 5-alpha reductase inhibitor, can better manage urinary symptoms and preserve sexual function in men with benign prostatic hyperplasia (BPH). The study includes 240…

This study is testing whether men can safely use tadalafil 5 mg (Cialis) for erectile dysfunction without a prescription. Participants will use a digital health survey to check if the drug is right for them before buying it. The goal is to see if people follow dosing instructions…

This clinical trial tests an investigational drug called tunodafil hydrochloride, taken as a tablet about one hour before sexual activity. The study enrolls men aged 18 to 65 with erectile dysfunction who have a stable female partner. Over 12 weeks, researchers measure changes in…

This phase 2 trial tests an experimental drug called LDP, an anti-PD-L1 monoclonal antibody that helps the immune system attack cancer cells. It enrolls adults with muscle-invasive bladder cancer, non-clear cell kidney cancer, or advanced penile cancer. Participants receive LDP i…

This early-stage trial is testing a combination of two lab-made antibodies in people with advanced solid tumors that have not responded to standard treatments. One antibody (LDP) aims to reactivate the immune system against cancer, while the other (CDP1) blocks a growth signal on…

This study tests a combination of three immunotherapy drugs—PDS0101, M7824, and NHS-IL12—in people with advanced HPV-related cancers such as cervical, anal, and throat cancers. The goal is to see if the mix can shrink tumors or stop them from growing. Participants receive the dru…

This study looked at 156 men with mild to mild-moderate erectile dysfunction who had not responded well to previous treatments. Half received platelet-rich plasma (PRP) injections into the penis plus a daily 5 mg tadalafil pill, while the other half got PRP injections alone. The …

This early-phase trial tested whether combining shockwave therapy with platelet-rich plasma (PRP) injections can improve erectile function in men with microvascular erectile dysfunction. Fifty-nine men received either the combination treatment or a sham procedure. The main goal w…

This study tested whether a combination of two chemotherapy drugs, gemcitabine and cisplatin, can shrink tumors in people with advanced or metastatic penile cancer. Fifty adults with inoperable or spreading disease took part. The main goal was to see how many patients responded t…

This study looked at 60 men with metabolic syndrome who also had erectile dysfunction and early signs of heart stiffness. Researchers compared three treatments: tadalafil (a common ED drug), an SGLT2 inhibitor (a diabetes drug), and a combination of both, given for three months. …

This study tested a new experimental treatment called HPVST cells in 32 people with HPV-related cancers that had returned or not responded to standard care. The cells are grown from the patient's own blood and trained to attack HPV-infected cancer cells. The goal was to find a sa…

This study tested a silicone block placed under the skin of the penis to improve its size, shape, and appearance. It included 40 men who were unhappy with their penile girth or length. The main goal was to check safety and measure changes in size and patient satisfaction.

This trial tested a new therapy for cancers caused by HPV-16, such as cervical, anal, and throat cancers. Researchers took patients' white blood cells, genetically engineered them to recognize a protein called E7 found in HPV cancer cells, and infused them back. Patients also rec…

This phase 2 trial tested a single injection of stem cells (from the patient's own bone marrow) into the penis to treat erectile dysfunction in men who had their prostate removed due to cancer. Fifty-four men participated. The study measured changes in erectile function scores us…

This study tested whether a single injection of a patient's own fat-derived stem cells into the penis could improve erectile dysfunction after prostate removal. 70 men who had poor erections for over a year after surgery were enrolled. Half received the stem cell injection, half …

This study tested a drug called crizanlizumab in 36 men with sickle cell disease who suffer from priapism—painful erections lasting an hour or more. The goal was to see if the drug could reduce how often these events happen. Participants received the drug by IV and reported their…

This early-phase trial tested whether injecting a man's own bone marrow stem cells into the penis could help restore erections after prostate cancer surgery. The study included 18 men who had normal erections before surgery but developed erectile dysfunction due to blood vessel d…

This trial tests whether a new hybrid tracer, ICG-99mTc-nanoscan, can replace the standard tracer for sentinel node biopsy in people with penile cancer, melanoma, or oral cancer. The hybrid tracer combines a fluorescent dye with a radioactive marker, potentially allowing surgeons…

This study looks at whether a blood test that detects tumor DNA can find early signs of cancer returning in people treated for HPV-positive pelvic cancers (like cervical or anal cancer). Researchers will take blood samples from 172 patients during regular follow-up visits. The go…

This study tested whether a 12-week Pilates program could improve erectile function in 60 men aged 40-60 with type 2 diabetes and erectile dysfunction. Participants did Pilates three times a week for 60 minutes each session. The study measured blood flow in the penis and used a q…

This pilot study tested low-intensity shock wave therapy (LiSWT) in 25 men with erectile dysfunction after a pelvic fracture and urethral injury. The treatment uses a device that delivers gentle shock waves to the penis to improve blood flow. Researchers measured changes in penil…

This study tested two treatments for erectile dysfunction (ED) in 185 men: a daily tadalafil pill (5 mg) and a nerve stimulation device (TENS) that sends mild electrical pulses to the penis. The goal was to see if these treatments improve blood flow and erection hardness. The tri…

This study tested whether adding radial shock wave therapy to standard sildenafil (Viagra) helps men with erectile dysfunction more than sildenafil alone. Eighty men with moderate ED were randomly assigned to receive either real shock waves or a fake treatment, plus sildenafil. T…

This study tested a topical gel called MED3000 for men with erectile dysfunction that persisted 1.5 to 4 years after prostate cancer surgery. Twenty men who had nerve-sparing prostatectomy used the gel on demand. The goal was to see if it improved erectile function enough to make…

This study followed 317 men who used a digital health app (Kranus EDERA) for erectile dysfunction to see if their improvements lasted. Participants completed questionnaires about erectile function, overall health, and quality of life up to 3 months after finishing the 12-week app…

This study tested whether adding a magnetic chair (extracorporeal magnetic innervation) to standard pelvic floor exercises helps men with premature ejaculation more than exercises alone. Forty-one men aged 25-45 took part over 8 weeks. Researchers measured pelvic floor muscle mov…

This study tested a drug called Tanzânia in 295 men who have both erectile dysfunction and an enlarged prostate (benign prostatic hyperplasia). The goal was to see if the drug improves erectile function better than a placebo. Participants took the drug or a dummy pill for a perio…

This study tested whether an injection of umbilical cord stem cell secretome is safe and can improve erections in 12 men with severe erectile dysfunction that did not respond to sildenafil (Viagra). All participants had type 2 diabetes. The treatment was given as a single injecti…

This study tested a new oral film form of sildenafil (the active ingredient in Viagra) at doses from 25 mg to 100 mg in 488 men with erectile dysfunction (ED). The goal was to see if the film is safe and effective compared to a placebo. Participants took the film as needed before…

This pilot study tested whether using a medical glue (2-octyl cyanoacrylate) with just a few stitches is as good as the usual method of continuous stitching for closing wounds after adult circumcision. Twenty men were randomly assigned to one of the two closure methods. Researche…

This study looks at why some men feel anxious about giving themselves penile injections for erectile dysfunction after pelvic surgery. Researchers will ask 126 men to fill out questionnaires before, during, and after injection training. The goal is to better understand and measur…

This completed study tested whether a new biomarker called 'mass response' can predict how well a cancer therapy will work. Researchers collected tumor cells from 72 patients with various cancers through fluid drainage or biopsies. The goal was to see if this biomarker could guid…

This study in 18 rats investigates whether alpha lipoic acid, a natural antioxidant, can protect penile tissue from damage caused by restoring blood flow after a prolonged painful erection (priapism). Researchers will measure various markers of oxidative stress and inflammation i…

This study translated a detailed questionnaire about male sexual function into French and tested it with 14 men who have sexual dysfunction. The goal was to see if the questions were clear and easy to understand. This is a first step toward having a reliable tool for French-speak…

This study tested 14 elite male road cyclists to see how different bike saddle designs affect oxygen and carbon dioxide levels in the penis. Riders used a stationary trainer while researchers measured blood gas changes over time. The goal was to compare a new 3D-printed saddle wi…

This study looked at whether a score called Modified EASIX, calculated from routine blood tests, can help predict how severe erectile dysfunction (ED) is. Researchers reviewed medical records of 380 men aged 18-65 and compared the score between those with and without ED. No treat…

This completed study looked at 97 men with type 2 diabetes to see if a non-invasive skin test for advanced glycation end-products (AGEs) could be linked to erectile dysfunction. AGEs build up due to high blood sugar and may damage blood vessels. Researchers used a device called A…