Penile disorder

This trial tests whether combining two drugs—pucotenlimab, which helps the immune system attack cancer, and becotatug vedotin, which delivers a toxin directly to tumor cells—can eliminate advanced penile cancer before surgery. Men with high-risk, locally advanced penile squamous …

This study compares two surgical methods to repair a short (up to 2 cm) narrowing in the bulbar urethra. One technique removes the scarred section and reconnects healthy ends; the other uses a graft from the lining of the testicle to widen the stricture. 94 men aged 18-50 with no…

This trial tests two experimental treatments for erectile dysfunction in men who have had robotic prostate surgery for prostate cancer. One group receives an injection of urine-derived exosomes into the penis, while the other gets ozone gas delivered through the rectum. Researche…

This study tests whether pelvic floor muscle training (PFMT) with a handheld biofeedback device can improve erectile function and sexual quality of life in men with functional hypogonadism (low testosterone) and erectile dysfunction. Participants are randomly assigned to PFMT wit…

This phase II trial tests a combination of two drugs—SYS6026 and Enlonstobart—in people with advanced solid tumors that have spread and are linked to HPV types 16 or 18. The study aims to see if the combination is safe and shows signs of shrinking tumors. Participants must be at …

This study compares two procedures for men with erectile dysfunction caused by a vein leak. One procedure blocks the leaking veins, and the other reroutes the main vein. The goal is to see which works better and is safer. About 60 men will take part.

This trial tests whether a combination of a daily erectile medication, pelvic floor exercises, aerobic exercise, dietary advice, and mental health support can improve erectile function and urinary control in men after robot-assisted prostate removal for prostate cancer. Sixty-fou…

This early-stage trial tests a lab-grown penile tissue made from a man's own cells to repair severe, irreversible damage to the penis. Ten men aged 18-60 who have failed standard treatments will receive the implant. The main goal is to check safety, not effectiveness.

This study tests a new combination of two drugs (becotatug vedotin and pucotenlimab) in 20 adults with advanced penile cancer that has spread and is EGFR-positive. Participants must have failed or be unable to tolerate chemotherapy. The goal is to see if the treatment can shrink …

This study tests a daily pill called upadacitinib for people with severe forms of lichen planus, a skin disease causing painful mouth sores or hair loss. About 56 adults will receive either the drug or a placebo for 16 weeks to see if it reduces symptoms. The goal is to control t…

This study tests whether injections of exosomes (tiny particles from umbilical cord stem cells) can safely improve erections in men aged 18–70 with moderate to severe erectile dysfunction who haven't responded well to standard pills. Seventy participants will receive six weekly i…

This study tests a new drug called YN001 in 40 people who have both atherosclerotic cardiovascular disease (hardening of the arteries) and erectile dysfunction. The trial is double-blind and placebo-controlled, meaning neither patients nor doctors know who gets the real drug. The…

This trial evaluates a new ultra-thin flexible penile monitoring system designed to diagnose erectile dysfunction (ED) by measuring nighttime erections. The current standard device, RigiScan, uses mechanical rings that can be uncomfortable and disrupt sleep, potentially skewing r…

This study tests whether the HPV vaccine can prevent the return of high-grade squamous intraepithelial lesions (HSIL) in people who have already been treated for them. About 984 adults aged 18–55 with HPV-related HSIL of the cervix, vulva, vagina, penis, or anus will receive eith…

This study tests whether adding an injection of Xeomin (a type of botulinum toxin) to the erectile dysfunction pill tadalafil can improve erections better than the pill alone. About 30 men with mild-to-moderate ED will receive both treatments in a crossover design. The goal is to…

This study tests whether adding telehealth sex therapy to standard pelvic floor physical therapy helps men recover urinary and sexual function after prostate cancer treatment. All participants receive pelvic floor therapy and education on using a vacuum erection device. Half are …

This early-stage trial tests a new fixed-dose combination pill called Viaca, which contains sildenafil and cabergoline, for erectile dysfunction. The study enrolls 30 healthy adult male volunteers to compare the safety, tolerability, and drug levels of the combination against eac…

This study tests whether a specific set of pelvic floor exercises (called Exercise G128) can help men with erectile dysfunction, urinary incontinence, or premature ejaculation. One hundred men aged 18 to 60 will do the exercises four times a week for one month and have bi-weekly …

This study tests whether adding Eroxon gel to the standard pill tadalafil can improve erections in men aged 18 to 40 with type 2 diabetes. Thirty men who already take tadalafil will use the gel before sex and report changes in erectile function. The goal is to see if the combinat…

This study tests whether injecting a long-lasting numbing medicine (Exparel mixed with bupivacaine) into the penis before placing an inflatable penile implant can reduce post-surgery pain and the need for opioid painkillers. One hundred men with erectile dysfunction who are getti…

This study tests whether placing a thin layer of the patient's own fat under a skin graft on the penis leads to better healing, feel, and function. Twenty-four men scheduled for reconstructive penile surgery will be randomly assigned to receive either the standard skin graft alon…

This study follows 130 men with unfavorable intermediate-risk prostate cancer to see how a combination of targeted radiation (SBRT) and 6 months of hormone therapy (ADT) impacts their sexual function. Researchers measure erectile function before treatment and again after 24 month…

This pilot study will test if low-intensity shockwave therapy can safely improve blood flow and ease symptoms in 30 men with erectile dysfunction caused by blood vessel problems. Participants will receive treatment using a special device and be monitored for side effects and chan…

This study tests whether acupuncture can improve erectile dysfunction in men who also have chronic prostatitis/chronic pelvic pain syndrome. One hundred men will receive either real or sham acupuncture over 8 weeks. The researchers will also use brain scans and blood tests to exp…

This study looks at whether having a moderate amount of alcohol changes how quickly and how well a liquid form of sildenafil (the active ingredient in Viagra) works for erectile dysfunction. Thirty-six men will take the medication under different conditions—with and without alcoh…

This early-stage study will compare how two new liquid forms of sildenafil (Hezkue and Hezkue Turbo) are absorbed in the body versus several commercial ED products like Viagra and chewable tablets. Seventy-two healthy men will take single doses after a meal, and researchers will …

This study tests two new erectile dysfunction (ED) treatments, Hezkue and Hezkue Turbo, against several standard sildenafil products. About 200 men with ED will use one of the assigned treatments as needed for 12 weeks. Researchers will measure improvements in erectile function, …

This Phase 3 study tests whether taking a low dose of two different erectile dysfunction drugs (tadalafil 2.5 mg plus sildenafil 25 mg) daily works better than taking a standard dose of just one (tadalafil 5 mg). The trial will involve 142 men aged 18 to 70 with ED for at least 3…

This study tests whether adding aerobic exercise (walking on a treadmill) and relaxation training to standard pelvic floor muscle training helps men recover bladder control and sexual function after prostate cancer surgery. Forty-eight men who had nerve-sparing robotic prostatect…

This study investigates whether erectile dysfunction (ED) in men being treated for high blood pressure is linked to a hidden heart condition called subendocardial ischemia, where the heart muscle doesn't get enough oxygen. Researchers will compare a noninvasive heart test called …

This study will collect information from 255 married diabetic men with erectile dysfunction (ED) in Pakistan. Researchers want to understand how common ED is, how severe it gets, and what treatments are used in real life. The goal is to improve care and guide health policies for …

This study looks at 50 children aged 1-18 having penile surgery to find the best place and depth for a pudendal nerve block. Doctors will measure how far from the anus and how deep the needle needs to go, and see if that relates to the child's age, height, and weight. The goal is…