Could two ED pills be better than one? new trial investigates

NCT ID NCT07177326

Not yet recruiting Symptom relief Sponsor: Assiut University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This Phase 3 study tests whether taking a low dose of two different erectile dysfunction drugs (tadalafil 2.5 mg plus sildenafil 25 mg) daily works better than taking a standard dose of just one (tadalafil 5 mg). The trial will involve 142 men aged 18 to 70 with ED for at least 3 months. Each participant will try both treatments in a random order, without knowing which they are taking, to compare effectiveness and safety.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tadalafil and sildenafil (two different PDE5 inhibitor drugs)
What this could lead to: If it works, this could offer a more effective daily option for men with erectile dysfunction who don't respond well to single-drug therapy.
What could go wrong: This is a small Phase 3 trial (142 men) and the combination may not prove significantly better than the standard dose. Side effects like headache or flushing could increase with two drugs.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

erectile dysfunction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ERECTILE DYSFUNCTION

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Other studies related to the condition(s) this trial covers.