Patellofemoral pain syndrome

This study tests whether a new medicine called Fexuprazan (Fexuclue) can prevent stomach ulcers caused by NSAID painkillers like ibuprofen. About 360 adults with joint or muscle pain who need daily NSAIDs will take either Fexuprazan or an older drug (Lansoprazole) for 24 weeks. T…

This study compares core stability exercises versus proprioceptive (balance) training in 63 adults aged 18-40 with patellofemoral pain syndrome (runner's knee). Participants will be assigned to one of two exercise programs to see which better reduces pain and improves knee functi…

This study investigates whether high-intensity laser acupuncture, combined with exercise, can reduce pain and improve knee function in people aged 18 to 25 with patellofemoral pain syndrome (front knee pain). Participants receive either real laser acupuncture or a sham laser, plu…

This study tests whether a device that delivers high-intensity electromagnetic pulses to the thigh muscles can reduce pain and improve quality of life in people with patellofemoral pain syndrome (front knee pain). Sixty adults with persistent knee pain will be randomly assigned t…

This study compares three types of knee-strengthening exercises (isometric, isotonic, and eccentric) in 90 adults aged 18-40 with patellofemoral pain syndrome. Participants will do their assigned exercises three times a week for 8 weeks, alongside standard physiotherapy. Research…

This study looks at whether changing running form with a wearable device can reduce knee pain in female runners with patellofemoral pain (runner's knee). 44 women aged 18-45 who run at least 15 km per week will be split into two groups: one gets gait retraining with a device, the…

This study tests whether a 6-week telerehabilitation program (done at home with remote guidance) works as well as in-person rehab for people with patellofemoral pain, a common knee condition. About 106 adults aged 18-45 will be randomly assigned to either remote or face-to-face s…

This trial tests a 6-week digital health program delivered through a smartphone app for people with patellofemoral pain (knee pain). 40 adults will either use the app or follow a self-guided exercise program. The goal is to see if the app improves knee function and reduces pain b…

This study tests whether taking tranexamic acid pills for a week after knee replacement surgery helps people recover better. 350 adults having their first knee replacement will receive either the drug or a placebo. Researchers will track pain, stiffness, and function for up to 2 …

This study compares two types of exercise programs—functional stabilization training and comprehensive corrective exercises—to see which better improves knee alignment and reduces pain in people with patellofemoral pain syndrome. Researchers will enroll 60 adults aged 18-35 who h…

This study compares two physical therapy treatments for patellofemoral pain syndrome, a common cause of knee pain. Forty-five participants will be randomly assigned to receive either Mulligan mobilization with movement, phonophoresis with chitosan gel, or standard exercises for 4…

This study looks at two different exercise programs—cadence training and elliptical training—to see which one better reduces knee pain and improves leg power and endurance in cricketers with patellofemoral pain syndrome. Forty-eight male cricketers aged 18 to 35 will be randomly …

This early-phase trial will test four orthobiologic treatments—PRP, bone marrow concentrate, hyaluronic acid, and nanofat—in 300 adults with various muscle, joint, tendon, or bone conditions. The goal is to see if these natural substances can reduce pain and improve joint functio…

This study tests a new digital system that uses wearable sensors, cameras, and AI to guide people through knee rehab exercises at home. It focuses on two common knee problems: ACL tears and patellar pain. 160 adults aged 18-50 will do strength, balance, and stretching exercises f…

This study tests a special exercise program that focuses on body awareness and coordination for people with patellofemoral pain syndrome (pain around the kneecap). Sixty adults with knee pain for at least 3 months will be randomly assigned to either this new rehab or standard phy…

This study tests whether an artificial intelligence-driven exercise program can reduce pain and improve knee function better than conventional exercises in people with patellofemoral pain syndrome. Forty adults aged 18 to 40 with knee pain lasting at least three months will be ra…

This study compares two different physiotherapy programs for people with patellofemoral pain syndrome (front knee pain). The goal is to see which approach—based on manual therapy and muscle training—provides better pain relief and knee function. 46 participants with knee pain las…

This study tests whether standing on a whole-body vibration platform while doing hip and knee exercises reduces pain and improves function in people with patellofemoral pain syndrome (a common cause of front knee pain). Forty adults aged 18 to 40 will be randomly assigned to eith…

This study looks at whether a mobile app can help people with common pains (neck, shoulder, back, or knee) do their prescribed home exercises more regularly. About 30 adults will be split into two groups: one using the app and one doing traditional exercises. The goal is to see i…

This study looks at how knee pain intensity relates to the knee's ability to sense its own position (proprioception) in people with patellofemoral pain syndrome. Researchers will measure pain and joint position error during a single-leg squat in 82 adults aged 18–35. The goal is …

This study aims to translate and adapt a widely used questionnaire for musculoskeletal problems into Urdu. Researchers will enroll 110 Urdu-speaking adults, including patients with muscle or joint issues and healthy volunteers. The goal is to create a validated tool to measure sy…

This study looks at how patients feel when reading their own medical notes. Some will read the original doctor's note, others will read a simpler version written by artificial intelligence. Researchers want to see if the AI summary changes how much patients trust their doctor or …

This observational study in Mexico will follow 30 adults already taking tirzepatide for conditions like diabetes or obesity. Researchers will use MRI scans of the knees, CT scans of the heart, and body composition tests to see how the drug affects cartilage, heart fat, and overal…

This study will follow 200 people who have had a complex or revision hip replacement at University Hospitals Leuven. The goal is to track how many need another surgery and why, and to improve care by learning from real-world results. No new treatment is being tested—this is an ob…

This study looks at how two common leg injuries—ankle sprains and kneecap pain—affect balance in different directions. Researchers will measure stability in 90 people using a special balance machine. The goal is to find out if each injury causes a unique type of balance problem, …

This study will use ultrasound to examine two specific thigh muscles in people with patellofemoral pain syndrome (front knee pain) and compare them to healthy individuals. Researchers aim to better understand how these muscles differ in people with knee pain, which could lead to …

This study tests a decision support system called SmaRTWork to help people on sick leave due to muscle or back pain return to work. About 298 adults in Norway will either use the system or receive usual care. The main goal is to see if the tool helps them return to work sustainab…

This study looks at how different body positions (lying on your side versus standing) affect hip muscle strength and activation in men with patellofemoral pain syndrome (PFPS), a common cause of knee pain. Researchers will compare 22 men with PFPS to 22 healthy men, measuring mus…