Patellofemoral pain syndrome
MONDO:0006894A syndrome characterized by retropatellar or peripatellar pain resulting from physical and biochemical changes in the patellofemoral joint. The pain is most prominent when ascending or descending stairs, squatting, or sitting with flexed knees. There is a lack of consensus on the etiology and treatment. The syndrome is often confused with (or accompanied by) chondromalacia patellae, the latter describing a pathological condition of the cartilage and not a syndrome.
86 clinical trials for this condition and its sub-types.
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Which exercise retrains the knee best? a Head-to-Head test
Disease control CompletedThis study compares two supervised exercise programs—motor control retraining and close kinetic chain exercises—to see which better reduces pain, improves knee function, and strengthens a key thigh muscle in people with patellofemoral pain syndrome (pain around the kneecap). Fift…
Phase: NA • Sponsor: University of Faisalabad • Aim: Disease control
Last updated Aug 16, 2026 00:00 UTC
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AI-Powered running coach aims to predict and prevent shin splints and Runner's knee
Disease control CompletedThis study uses machine learning to identify biomechanical risk factors for common running injuries like shin splints, runner's knee, and Achilles tendon pain in recreational runners. Participants undergo motion capture and muscle activity analysis while running, then are followe…
Phase: NA • Sponsor: Zeyi Zhang • Aim: Disease control
Last updated Jul 10, 2026 00:00 UTC
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Knee implant study shows good function after two years
Disease control CompletedThis study looked at how well a specific knee replacement (balanSys UNI) works over time. 116 people with knee arthritis got the implant and were followed for at least 2 years. Doctors measured knee function using the Knee Society Score and checked X-rays for any problems.
Sponsor: Mathys Ltd Bettlach • Aim: Disease control
Last updated Jun 27, 2026 09:02 UTC
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A simple hip exercise may boost knee pain recovery — trial puts it to the test
Symptom relief CompletedThis trial tests whether adding clamshell exercises — a hip-strengthening move — to standard physical therapy can better reduce pain and improve knee function in people with patellofemoral pain syndrome (pain around the kneecap). Forty adults aged 18 to 45 with this common knee c…
Phase: NA • Sponsor: Ibadat International University, Islamabad • Aim: Symptom relief
Last updated Jul 30, 2026 00:00 UTC
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Could Splash-Based workouts soothe teen knee pain?
Symptom relief CompletedThis study tests whether a 12-week program of water-based jumping and hopping exercises (hydro-kinetic plyometrics) can reduce pain, strengthen leg muscles, and improve quality of life in adolescents with patellofemoral pain syndrome (PFPS). Fifty-six teens aged 10–18 with persis…
Phase: NA • Sponsor: Cairo University • Aim: Symptom relief
Last updated Jul 03, 2026 00:00 UTC
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Core strength may be key to easing knee pain in young women
Symptom relief CompletedThis study looks at whether adding core muscle exercises to a hip and knee workout can lower pain and improve knee alignment in women with patellofemoral pain syndrome (knee pain around the kneecap). Thirty-six women aged 19-35 with a healthy weight will be assigned to different …
Phase: NA • Sponsor: Cairo University • Aim: Symptom relief
Last updated Jul 03, 2026 00:00 UTC
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Which exercise wins for knee pain? study puts clam shells and quad moves to the test
Symptom relief CompletedThis study compared two types of exercises—clam shell exercises (for hip muscles) and short arc quadriceps exercises (for thigh muscles)—in 34 adults aged 18-40 with patellofemoral pain syndrome, also known as runner's knee. Participants were randomly assigned to one exercise gro…
Phase: NA • Sponsor: Green International University • Aim: Symptom relief
Last updated Jun 27, 2026 13:06 UTC
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Finger-Guided knee surgery offers less trauma for patellar pain
Symptom relief CompletedThis study tested a minimally invasive surgery for people with kneecap pain, dislocation, or instability. Surgeons used their finger to guide a small cut to release tight ligaments, aiming for less tissue damage than open surgery. 23 participants were enrolled. The approach may r…
Phase: NA • Sponsor: Issa, Abdulhamid Sayed, M.D. • Aim: Symptom relief
Last updated Jun 27, 2026 13:04 UTC
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App-Based rehab boosts exercise adherence for chronic knee pain
Symptom relief CompletedThis study tested whether a mobile app with sensors could help 174 adults with chronic kneecap pain follow their home exercise program. Participants received 1, 3, or 6 face-to-face remote training sessions and then exercised on their own for 6 weeks. The app tracked how much the…
Phase: NA • Sponsor: Peking University Third Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 12:39 UTC
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Can heat or contrast therapy ease your knee pain? new study finds out
Symptom relief CompletedThis study looked at whether adding heat therapy or contrast therapy (alternating hot and cold) to a specific exercise program helps people with patellofemoral pain syndrome, a common cause of front knee pain. Forty adults aged 18 to 40 with at least three months of knee pain too…
Phase: NA • Sponsor: Lahore University of Biological and Applied Sciences • Aim: Symptom relief
Last updated Jun 27, 2026 12:36 UTC
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Mindful miles: could meditation while running ease knee pain?
Symptom relief CompletedThis pilot study tested whether a progressive outdoor mindful running program, guided by the Headspace app, is feasible and helpful for adults with patellofemoral pain (front knee pain). 18 participants completed a 5-week program that introduced mindfulness and guided mindful run…
Phase: NA • Sponsor: University of North Carolina, Chapel Hill • Aim: Symptom relief
Last updated Jun 27, 2026 12:35 UTC
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Knee pain relief showdown: which technique wins?
Symptom relief CompletedThis study tested two manual therapy techniques—Strain Counterstrain and Graston Technique—in 60 adults with patellofemoral pain syndrome (pain around the kneecap). The goal was to see which method better reduces pain and improves knee movement right after treatment. Participants…
Phase: NA • Sponsor: Green International University • Aim: Symptom relief
Last updated Jun 27, 2026 12:34 UTC
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Simple hip and ankle moves may ease soccer Players' knee pain
Symptom relief CompletedThis study looked at whether a 6-week exercise program focusing on hip and ankle mobility could help male soccer players with a common type of knee pain called patellofemoral pain. 48 players were split into two groups: one did the special exercises plus their regular training, w…
Phase: NA • Sponsor: Beijing Sport University • Aim: Symptom relief
Last updated Jun 27, 2026 12:26 UTC
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New study tests simple running tweaks to beat Runner's knee
Symptom relief CompletedThis study looked at two remote running programs for people with runner's knee (patellofemoral pain). One group was asked to increase their step rate and run less, another just ran less, and a third group kept running as usual. The goal was to see if these changes could reduce kn…
Phase: NA • Sponsor: Cardiff Metropolitan University • Aim: Symptom relief
Last updated Jun 27, 2026 12:09 UTC
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Stretching your way to better hips? pilot study tests the idea
Symptom relief CompletedThis pilot study looked at whether passive static stretching can increase hip flexibility in three groups: people who had hip replacement, those with long-term hip pain, and healthy volunteers. Twelve participants followed a 4-week stretching program three times a week under supe…
Sponsor: Omicron beta research • Aim: Symptom relief
Last updated Jun 27, 2026 12:00 UTC
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New massage method offers hope for knee pain sufferers
Symptom relief CompletedThis study tested whether adding a specific massage technique (myofascial release) to standard physical therapy could improve quality of life for people with chronic knee pain. 45 adults with knee pain participated. The approach focused on a small muscle behind the knee called th…
Phase: NA • Sponsor: Istanbul Rumeli University • Aim: Symptom relief
Last updated Jun 27, 2026 11:03 UTC
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New gel combo for aching muscles: does it beat standard pain relievers?
Symptom relief CompletedThis study tested whether a gel containing piroxicam plus warming and cooling ingredients (methyl salicylate, menthol, eugenol) works as well as standard piroxicam-only or diclofenac gels for muscle and joint pain. 180 adults with conditions like ankle sprain, back pain, or knee …
Phase: PHASE3 • Sponsor: Taisho Pharmaceutical Indonesia • Aim: Symptom relief
Last updated Jun 27, 2026 11:01 UTC
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Which workout wins for Runner's knee? new study pits resistance vs. neuromuscular training
Symptom relief CompletedThis study looked at 38 young male runners with patellofemoral pain syndrome (runner's knee) to see which type of exercise helps more: resistance training or neuromuscular training. Both groups did their assigned exercises, and researchers measured leg power, knee function, and b…
Phase: NA • Sponsor: Riphah International University • Aim: Symptom relief
Last updated Jun 27, 2026 08:09 UTC
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Shock wave therapy fails to boost knee pain relief in small trial
Symptom relief CompletedThis study tested whether adding shock wave therapy to a home exercise program could reduce knee pain and improve function in adults with patellofemoral pain syndrome (a common cause of front knee pain). Thirty-six people aged 18–45 were split into three groups: exercise only, sh…
Phase: NA • Sponsor: Uğur Can Yalaki • Aim: Symptom relief
Last updated Jun 27, 2026 08:03 UTC
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Adding hip or ankle moves to knee exercises eases pain in women with Runner's knee
Symptom relief CompletedThis study tested whether adding hip or ankle exercises to standard knee strengthening could help women with patellofemoral pain syndrome (anterior knee pain). Forty-five female recreational athletes aged 20-40 completed an 8-week telehealth-supervised program. Both the hip-plus-…
Phase: NA • Sponsor: Kaohsiung Medical University Chung-Ho Memorial Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 07:54 UTC
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Robot-Assisted knee surgery may outperform traditional methods
Symptom relief CompletedThis study compared robotic-assisted total knee replacement to the conventional technique in 95 patients with knee arthritis. The goal was to see if robotic surgery leads to better knee function, less pain, and higher satisfaction two years after the operation. Researchers also c…
Phase: NA • Sponsor: Hospital de Terrassa • Aim: Symptom relief
Last updated Jun 27, 2026 07:53 UTC
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Smartwatch coaching eases Runner's knee in small trial
Symptom relief CompletedThis study tested whether a wearable device that coaches runners to take quicker, shorter steps can reduce knee pain in female runners with patellofemoral pain (runner's knee). 44 women were split into two groups: one used a smartwatch app to increase their step rate by 10%, whil…
Phase: NA • Sponsor: Beijing Sport University • Aim: Symptom relief
Last updated Jun 26, 2026 17:46 UTC
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Scientists use MRI to uncover muscle secrets behind knee pain
Knowledge-focused CompletedThis study looks at how the thigh muscles control the movement of the knee cap in people with long-term knee cap pain. Researchers will use MRI scans to compare knee movement in people with pain and healthy volunteers. In a second session, they will temporarily numb a thigh muscl…
Sponsor: National Institutes of Health Clinical Center (CC) • Aim: Knowledge-focused
Last updated Aug 09, 2026 00:00 UTC
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Can a simple balance test predict sports injuries in teens?
Knowledge-focused CompletedThis study is observing 85 male teen athletes aged 15-17 to see how their trunk mobility, hamstring flexibility, and balance differ by sport. No treatments are given—just measurements using a digital inclinometer and balance tests. The goal is to spot physical traits that might r…
Sponsor: Eastern Mediterranean University • Aim: Knowledge-focused
Last updated Jul 22, 2026 00:00 UTC
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Knee pain study aims to uncover hidden movement clues
Knowledge-focused CompletedThis study looked at 45 people with patellofemoral pain syndrome (pain around the kneecap) to see if different types of the condition have unique movement problems. Participants had X-rays and walking tests to measure how their knees move. The goal was to better understand the co…
Phase: NA • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jul 03, 2026 00:00 UTC
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Scientists numb a single knee muscle to uncover pain secrets
Knowledge-focused CompletedThis study looks at how the muscles around the knee work together to control movement, especially in the kneecap area. Researchers temporarily numbed one muscle with lidocaine in 28 healthy volunteers and used MRI scans to see how the knee moved. The goal is to better understand …
Sponsor: National Institutes of Health Clinical Center (CC) • Aim: Knowledge-focused
Last updated Jul 02, 2026 00:00 UTC
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Kneecap pain study probes muscle oxygen use during exercise
Knowledge-focused CompletedThis study looked at how the quadriceps (thigh) muscle uses oxygen in people with patellofemoral pain (pain around the kneecap) compared to pain-free individuals. Researchers measured muscle oxygenation using a light-based device during activities like squatting and stair climbin…
Sponsor: Ankara Medipol University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:03 UTC
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Knee pain in young athletes linked to hip and core weakness
Knowledge-focused CompletedThis completed study looked at 75 elite teen track-and-field athletes, half with patellofemoral pain syndrome (PFPS) and half without. Researchers measured hip flexibility, core endurance, and knee alignment to see what factors are linked to knee pain. They found that athletes wi…
Sponsor: Eastern Mediterranean University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:10 UTC