Patellofemoral pain syndrome
MONDO:0006894A syndrome characterized by retropatellar or peripatellar pain resulting from physical and biochemical changes in the patellofemoral joint. The pain is most prominent when ascending or descending stairs, squatting, or sitting with flexed knees. There is a lack of consensus on the etiology and treatment. The syndrome is often confused with (or accompanied by) chondromalacia patellae, the latter describing a pathological condition of the cartilage and not a syndrome.
86 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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Can a cheaper plastic knee implant match the metal one in older adults?
Disease control TerminatedThis trial compares two types of knee replacement implants in people aged 75 and older: a standard metal-backed component and a cheaper all-polyethylene (plastic) one. The goal is to see if the all-polyethylene implant performs as well in terms of pain relief, movement, and how l…
Phase: NA • Sponsor: Maidstone & Tunbridge Wells NHS Trust • Aim: Disease control
Last updated Jul 31, 2026 00:00 UTC
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Hip and foot moves may ease stubborn knee pain — a trial puts the theory to the test
Symptom relief ENROLLING_BY_INVITATIONThis trial investigates whether adding a gentle hip ligament stretch to a foot joint mobilization can reduce pain and improve knee function in people with patellofemoral pain syndrome (PFPS), a common cause of front knee pain. Eighty adults with PFPS will receive either standard …
Phase: NA • Sponsor: Cairo University • Aim: Symptom relief
Last updated Jul 31, 2026 00:00 UTC
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Can virtual therapy ease knee pain as well as in-person visits?
Symptom relief OngoingThis study tests whether doing physical therapy from home (via video calls or a mix of home and clinic visits) works as well as going to a clinic in person for young adults with patellofemoral pain syndrome, a common cause of front knee pain. About 42 people aged 18 to 35 will be…
Phase: NA • Sponsor: Cairo University • Aim: Symptom relief
Last updated Jun 27, 2026 13:02 UTC
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Knee pain relief: targeted exercises show promise in small trial
Symptom relief OngoingThis study tests two types of exercise for people with a common knee condition called patellofemoral pain. One group does neuromuscular control exercises (like balance and coordination), the other does muscle strengthening. Researchers will measure pain, function, and movement in…
Phase: NA • Sponsor: Universidade do Porto • Aim: Symptom relief
Last updated Jun 27, 2026 12:37 UTC
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Which exercise eases knee pain best? new trial tests two approaches
Symptom relief OngoingThis study compares two exercise programs—closed kinetic chain exercises and isometric exercises—to see which better reduces pain and improves function in women aged 35-60 with patellofemoral pain syndrome and knee osteoarthritis. Seventy participants will be randomly assigned to…
Phase: NA • Sponsor: Dow University of Health Sciences • Aim: Symptom relief
Last updated Jun 27, 2026 12:35 UTC
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Power up your knees: new exercise program aims to beat chronic kneecap pain
Symptom relief OngoingThis study tests whether a 6-week strength training program that includes power exercises (STRIPE) works better than standard rehab for people with long-term kneecap pain. 88 adults aged 18-40 with pain lasting over 3 months will do supervised telehealth sessions three times a we…
Phase: NA • Sponsor: University of Connecticut • Aim: Symptom relief
Last updated Jun 27, 2026 12:08 UTC
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Boston marathon study tests online education for Runner's knee
Symptom relief ENROLLING_BY_INVITATIONThis study looks at whether a 6-week, self-guided online education program can help Boston Marathon runners with patellofemoral pain (runner's knee) feel better and run better. About 104 runners will be split into two groups: one gets the program before the marathon, the other af…
Phase: NA • Sponsor: Boston Children's Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 11:00 UTC
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Trail vs. tarmac: which running surface spares your knees?
Knowledge-focused OngoingThis study surveys 134 recreational runners to see if the type of surface they run on (like asphalt or trail) and how much they train is linked to patellofemoral pain, a common knee problem. Participants answer questions about their running habits and any knee pain they've had. T…
Sponsor: University of Oviedo • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:28 UTC
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Hip implant under the microscope: 5-Year safety study launched
Knowledge-focused OngoingThis study is tracking 120 people who received a HYPE SCS hip stem during total hip replacement. Researchers will monitor how long the implant lasts, how satisfied patients are, and any complications over 5 years. The goal is to confirm the device is safe and works as intended in…
Sponsor: Societe dEtude, de Recherche et de Fabrication • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Can dry needling rewire the Brain's response to knee pain?
Knowledge-focused OngoingThis study looks at how chronic bilateral knee pain changes the brain's ability to recognize left from right, and whether dry needling can improve movement and muscle function. Sixty adults aged 18 to 40 with patellofemoral pain will be split into groups based on their fear of mo…
Phase: NA • Sponsor: Ohio State University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:08 UTC
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Danish knee pain scale gets a scientific makeover
Knowledge-focused OngoingThis study aims to create a Danish version of the Anterior Knee Pain Scale (Kujala), a questionnaire used to assess knee pain and function in people with patellofemoral disorders. Researchers will translate the original English questionnaire into Danish and then test its accuracy…
Sponsor: Aarhus University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:52 UTC