Scientists numb a single knee muscle to uncover pain secrets
NCT ID NCT00978003
First seen Jun 27, 2026 · Last updated Jul 01, 2026 · Updated 2 times
Summary
This study looks at how the muscles around the knee work together to control movement, especially in the kneecap area. Researchers temporarily numbed one muscle with lidocaine in 28 healthy volunteers and used MRI scans to see how the knee moved. The goal is to better understand what causes front knee pain, known as patellofemoral pain syndrome.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
lidocaine injection
What this could lead to
If successful, this could help researchers better understand the muscle imbalances that cause front knee pain, potentially guiding future treatments.
What could go wrong
This is a small, early-stage study in healthy volunteers, not patients. The temporary muscle block may not fully mimic real-world conditions, and findings may not apply to people with knee pain.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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National Institutes of Health Clinical Center
Bethesda, Maryland, 20892, United States