Myocardial ischemia

This Phase 3 trial tests whether a tenecteplase biosimilar called GNR-060 works as well as the reference drug Metalyse in people having a severe heart attack known as ST elevation myocardial infarction. Participants receive a single weight-based intravenous dose of one drug or th…

This trial tests whether using detailed CT images of the heart's arteries to plan invasive procedures can reduce radiation exposure, procedure time, contrast use, and tools needed. Adults with stable angina and significant blockages are randomly assigned to receive either standar…

This early-stage trial is testing a new gene therapy called AB-1002 in people with advanced heart failure (NYHA Class III). The therapy is given as a single infusion directly into the heart's blood vessels, aiming to deliver a gene that may help heart muscle pump more effectively…

This phase 3 trial investigates whether N-acetyl cysteine (NAC), an antioxidant supplement, can improve recovery in people hospitalized with an acute ischemic stroke. Participants receive either NAC or a placebo (saline) shortly after admission, and researchers track their neurol…

This study investigates whether replacing missing teeth with fixed dental prosthetics can improve blood sugar and cholesterol levels in people with ischemic heart disease. Participants aged 45 to 70 with stable heart disease and missing teeth receive the dental treatment. Researc…

This study tested whether using a heart MRI to find scar tissue can help decide which people with mild-to-moderate heart failure should get a defibrillator (ICD) to prevent sudden cardiac death. About 449 adults with a weakened heart pump (ejection fraction 36-50%) and scar tissu…

This study tests whether spermidine, a natural substance found in foods like soy and aged cheese, can improve heart and muscle health in elderly people with coronary artery disease. 180 participants aged 65 and older will receive either spermidine capsules or a placebo for a peri…

This early-phase study tested whether a single infusion of donor stem cells could help repair damaged blood vessels in 26 adults with type 2 diabetes and symptomatic heart disease. Researchers measured blood vessel function and looked for signs of repair in the lab. The goal was …

This study tested a program to help veterans with heart disease or rheumatic conditions take their medications as prescribed. Over 5,000 participants received reminders via text or phone calls, with extra support if needed. The goal was to improve medication adherence and reduce …

This study compared two medications, levosimendan and adrenaline, given during heart bypass surgery to patients with weak hearts (ejection fraction 30-40%). Sixty adults aged 18-65 having elective surgery were included. The goal was to see which drug better supports heart functio…

This early study tested a single injection of HM2002, a circular RNA, given directly into the heart muscle during bypass surgery. Only 3 people with heart failure took part. The main goal was to check safety, not to prove it works. The study is complete, but results are not yet a…

This study looked at 121 people with heart disease who were getting a stent. Researchers checked if they also had a silent H. pylori stomach infection and whether treating that infection reduced stomach symptoms or bleeding. The goal was to see if eradicating the bug helps patien…

This study looked at 556 people with coronary artery disease to confirm that the Orsiro drug-eluting stent is safe and effective in everyday use. The stent releases sirolimus to prevent artery re-narrowing. Researchers tracked how many patients had heart-related death, heart atta…

This study tested a program to help people with heart disease, stroke, or heart failure in India. The program used non-physician health workers, text messages about healthy living, and a computer tool to help doctors make decisions. 410 adults took part to see if the program impr…

This study tracked 161 patients with coronary artery disease who were treated with the Essential Pro device in routine hospital practice. The goal was to confirm the device's safety and performance, such as freedom from heart attack or repeat procedures. Results support its conti…

This study tested a very small balloon catheter (Sapphire 3) in 170 people with severely blocked heart arteries (chronic total occlusions). The balloon was used to open the blockage before placing a stent. The main goal was to see if the device could be safely delivered, inflated…

This study tested two different solutions used to protect the heart during bypass surgery. One is a modified version of a common fluid (Ringer acetate), the other is a standard solution (HTK). Researchers checked which one led to fewer abnormal heart rhythms and less heart muscle…

This study tested a virtual cardiac rehabilitation program using a smartphone app, a fitness wristband, and a blood pressure monitor for people who recently had a heart attack, heart surgery, or a stent. The goal was to see if this home-based program could improve walking ability…

This completed trial tested whether taking two blood thinners (clopidogrel and aspirin) for 12 months after a heart stent procedure is better than aspirin alone for people with multiple blocked coronary arteries. Over 8,000 patients were enrolled across 100 centers. The main goal…

This study looked at 1,424 veterans at high risk for heart problems who had major surgery. It compared two approaches to blood transfusion: a liberal strategy (transfusing when hemoglobin drops below 10) versus a restrictive strategy (transfusing only when hemoglobin drops below …

This study tested whether video education using deepfake technology—where an AI replicates the patient's own doctor's voice—could improve blood pressure monitoring and medication adherence in 218 adults with both ischemic heart disease and hypertension. Participants were randomly…

This early-phase trial tested a gene therapy called VM202RY in 9 people with ischemic heart disease who had incomplete revascularization after bypass surgery. The therapy was injected directly into heart muscle areas that still had poor blood flow. The main goal was to check safe…

This study tested a 'no-touch' method for taking veins from the leg during heart bypass surgery, compared to the usual technique. Over 900 patients were followed for two years to see if the no-touch method kept the vein grafts open better. The goal is to improve long-term success…

This study tested a new MRI technique that lets patients breathe normally during heart scans, instead of holding their breath. Researchers used special software (GRICS) to remove motion artifacts. They compared the free-breathing images to standard breath-hold images in 30 adults…

This study compared two types of heart scans—CT and PET—to see if CT can measure blood flow to the heart as accurately as PET, which is the current gold standard. Researchers enrolled 20 adults with suspected coronary artery disease. Each participant received both a CT scan and a…

This study tested whether a new MRI technique using artificial intelligence (deep learning) can accurately measure heart function while patients breathe normally, instead of holding their breath. The standard method requires repeated breath-holds, which can be hard for people wit…

This study tests whether watching an augmented reality (AR) educational video on a tablet can lower anxiety in people about to undergo cardiac catheterization, a common heart procedure. Participants in the experimental group view the AR video in addition to receiving standard pap…

This study compares two types of nerve blocks (ESPB and SPSIPB) to manage pain after heart bypass surgery. About 60 adults aged 18-80 having planned bypass surgery will take part. The goal is to see which block reduces the need for painkillers and improves comfort after surgery.

This study tested problem-solving therapy (PST) for adults with type 2 diabetes or heart disease who also have poor mental well-being. PST is a structured talk therapy where patients list their problems, weigh solutions, and take action. The trial involved 147 patients in general…

This study tested whether patient education and activity-based training help people recover daily living skills after a heart attack. 42 participants who had a heart attack with good heart function received one-on-one education at discharge and again two weeks later. The goal was…

This study tested whether a home-based breathing exercise program, guided by video calls, can improve quality of life, heart and lung function, and mood in 104 adults with ischemic heart disease. Participants did either a combined inspiratory and expiratory muscle training, inspi…

This study tested a 6-week program called Heart Up! that uses text messages and social support to help adults with heart disease become more physically active and feel less hopeless. About 224 patients who had a heart attack or related procedure took part. The program aimed to im…

This study tested whether interactive physical therapy (using computer-based balance and strength exercises) could help frail older adults recover better after open heart surgery. 153 participants aged 65 and older were assigned to either multicomponent training or computer-based…

This completed study looked at how much radiation people receive during heart CT scans (CCTA) in everyday hospital practice. Researchers enrolled 66 adults who needed a heart CT and recorded the radiation dose used, along with any dose-saving techniques. The goal was to understan…

This trial investigates whether genetic variations in the CES1 gene influence how the body responds to the blood thinners clopidogrel and aspirin. Healthy Amish adults will take clopidogrel for a week, then a single dose of aspirin, with blood tests measuring platelet function be…

This study looked at two ways to assign care coordinators to older adults (65+) with heart disease or risk factors. One method used patients' own reports of difficulty coordinating care, while the other used usual triggers like hospital discharge. The goal was to see which approa…

This study examined how being obese (BMI over 30) affects hospital outcomes after coronary artery bypass grafting (CABG) in 500 patients with chronic ischemic heart disease. Researchers tracked death rates, neurological injury, kidney injury, breathing machine time, and need for …

This completed study observed 528 adults who had heart surgery and were admitted to the intensive care unit (ICU). Researchers tracked deaths, serious complications like stroke or infection, and patient details to identify risk factors. The goal is to use this information to impr…

This study tested whether specially designed educational videos, sent through a mobile messaging app, could help people with coronary heart disease improve their fitness and heart health knowledge during a 12-week home-based cardiac rehabilitation program. Twenty-one participants…

This study looked at 150 patients who had a heart attack 12 to 36 hours earlier. Researchers wanted to see if opening the blocked artery right away was better than waiting a few days. They used MRI scans to measure heart muscle damage and function.

This study looked at two different heart stents (tiny mesh tubes used to open blocked arteries) to see which one works better in routine hospital care. Over 1,000 patients who needed a stent took part. The goal was to compare costs, procedure time, and how many extra devices were…

This study checked if certain blood markers can predict serious heart events like heart attack or death within a year after a stent procedure. Researchers measured two types of cells related to blood vessel health in 170 adults scheduled for a stent. The goal was to see if these …

This study looked at how men and women's brains and hearts react to mental stress. Researchers used special brain and heart scans on 64 healthy adults aged 50-75. The goal was to understand if stress affects heart health differently based on sex. No treatment was given; this was …

This study looked at 80 adults having heart valve or aortic surgery to find out how long a special heart protection solution (Del Nido cardioplegia) keeps the heart safe during surgery. Researchers took blood samples at set times to see when heart injury began. The goal was to le…

This study tested whether an augmented reality (AR) tool, accessed via a QR code on a smartphone, could help heart patients better understand their discharge instructions. 303 adults hospitalized for heart attack, heart failure, atrial fibrillation, or pacemaker implantation took…

This study looked at whether the time of day a person has heart surgery changes how their heart muscle tolerates the stress of the procedure. Researchers took small tissue samples from the hearts of 88 patients having planned heart surgery, either in the morning or afternoon. The…

This study looked at 1,695 people with stable heart disease affecting multiple arteries. Researchers compared long-term outcomes for those who had bypass surgery, stents, or took medication only. The goal was to see which approach best prevents heart attacks and heart-related dea…

This study looked at how well a special heart MRI (called stress CMR) finds blocked arteries in real hospitals, not just research centers. Researchers tracked 2,349 people aged 35-85 who had symptoms of heart disease. They recorded heart attacks, deaths, and hospital visits to se…

This completed study examined blood samples from 40 adults to see if high levels of lipoprotein (a), a type of cholesterol, are linked to fewer or different blood vessel repair cells. Participants with high Lp(a) were compared to those with normal levels. The goal was to better u…

This completed study looked at whether patients hospitalized for a heart attack, stroke, or other cardiovascular event received the right medications to prevent future problems. Researchers reviewed records of 129 patients to see if doctors prescribed cholesterol-lowering drugs a…

This study looked at whether using a thin, 7-French sheath through a small artery in the wrist is safe and effective for opening blocked heart arteries. 100 adults with heart disease took part. The goal was to see if this approach causes fewer bleeding or artery problems while st…

This study looked at whether silent myocardial ischemia (reduced blood flow to the heart without chest pain) increases the risk of heart problems or death in people with coronary heart disease. Researchers followed participants for one to three years. The goal was to better under…

This study tested a strategy to decide which patients need additional artery-opening treatment after a TAVI heart valve procedure. Researchers used a special imaging scan (SPECT) to look for areas of the heart not getting enough blood. The goal was to see if this imaging-guided a…

This study tested whether rotigaptide, a drug that improves cell communication, can protect blood vessel function after a temporary blockage of blood flow (ischemia-reperfusion injury). Twelve healthy men received the drug or a placebo while their forearm blood flow was measured.…

This study tested new MRI methods to detect bleeding inside the heart muscle after a heart attack. Researchers studied 14 patients to see if these scans could better identify damage that raises the risk of heart failure. The goal was to improve imaging, not to test a treatment.