Mitral valve insufficiency

This early trial tests a new device called Anchord that repairs leaky mitral valves without open-heart surgery. It will include 5 people with severe valve leakage who are too high-risk for standard surgery. The goal is to see if the device is safe and can reduce the leak, improvi…

This study tests a new device called the X-Clip, which is used to repair a leaky mitral valve without open-heart surgery. The device is inserted through a blood vessel and clips the valve to help it close better. The trial will include 15 adults with moderate-to-severe or severe …

This study tests whether special force feedback instruments, used with the da Vinci surgical robot, can safely and effectively repair leaky mitral valves. The trial includes 30 adults with moderate-to-severe mitral regurgitation. Researchers will check for major complications and…

This study tests a step-by-step treatment plan for people with a narrowed aortic valve who also have leaky mitral or tricuspid valves. After a minimally invasive procedure to fix the aortic valve, doctors will check if the other valves still leak badly. If so, additional procedur…

This early study tests a new device called the SATURN TS TMVR System, which is implanted through a catheter to replace the mitral valve in people with severe mitral regurgitation. Up to 15 patients who are too high-risk for open-heart surgery will be enrolled. The goal is to see …

This small pilot study will test a program where nurses and general practitioners help breast cancer survivors who also have heart disease make healthy lifestyle changes. The program includes exercise, diet changes, quitting smoking, and stress-reducing activities like yoga. The …

This study tests whether the drug vericiguat can prevent serious heart and organ problems in people undergoing heart surgery. About 600 high-risk patients will receive either vericiguat plus standard care or standard care alone. The goal is to see if vericiguat reduces early comp…

This study tests whether valsartan, a common blood pressure drug, can slow the worsening of atrial functional mitral regurgitation (a leaky heart valve) in 50 adults with normal heart pumping function. Participants take either valsartan or a placebo twice daily for 12 months, wit…

This study tests whether creating a small opening between the upper heart chambers during mitral valve repair can prevent heart failure symptoms after surgery. Researchers will compare 50 patients who get the extra opening to those who have standard surgery alone. The goal is to …

This registry follows 1,000 adults with mitral regurgitation who receive the MitraClip G5, a device that repairs the heart valve without open-heart surgery. Researchers will measure how well the procedure reduces valve leakage and improves symptoms like shortness of breath. All d…

This early study tests a special cap that shines near-infrared light on the heads of infants who have had a cardiac arrest in the hospital. The light is meant to reduce brain injury caused when blood flow returns. The trial will include 30 infants with heart disease and will chec…

This study tests a new method for closing the breastbone after coronary artery bypass graft (CABG) surgery using special knotless barbed sutures and a skin adhesive. Researchers will compare 401 adults who receive this new closure to past patients who had standard closure. The go…

This early study tests a new device called CARLEN for people with a leaky heart valve (functional mitral regurgitation). The goal is to see if the device is safe and works well. About 30 adults with moderate-to-severe symptoms will be enrolled, and the main focus is on any seriou…

This early study tests a device called the MRace implant to treat moderate-to-severe mitral regurgitation, a condition where the heart valve leaks. About 15 people will get the implant and be followed for up to 5 years to see if it safely reduces the leak and improves symptoms. T…

This early study tests a new device that fixes a leaky mitral valve without open-heart surgery. It is for people with severe symptoms who are too high-risk for traditional surgery. Only 5 participants will be enrolled to check if the device is safe and works as intended.

This study tests whether a special clinic where heart, kidney, diabetes, and liver doctors work together can help people with type 2 diabetes and heart disease get better control of their blood pressure and cholesterol. About 150 adults will be randomly assigned to either usual c…

This study follows 110 patients who had mitral valve repair surgery using the Chord-X system to see how well the device holds up over 10 years. Researchers will check for return of moderate-to-severe mitral regurgitation and other safety issues. Participants agree to share their …

This trial tests a procedure called TEER, which uses a clip to repair a leaky heart valve (mitral regurgitation) caused by an irregular heartbeat (atrial fibrillation). The study will include 400 people with moderate-to-severe or severe leakage who still have symptoms despite tak…

This registry will follow 150 people with severe mitral regurgitation who receive the HighLife transcatheter mitral valve replacement system. The goal is to see how well the device works and how safe it is when used in everyday medical practice. Participants are treated according…

This study tests a community-based exercise program for people aged 50 and older who have at least two chronic conditions, such as heart disease, diabetes, arthritis, or obesity. The program is designed to improve muscle strength, heart and lung fitness, and overall well-being. R…

This study looks at people with atrial fibrillation (an irregular heartbeat) who have already had a successful mitral valve repair. It compares two approaches: catheter ablation (a procedure to fix the heart's electrical signals) versus standard medical care. The goal is to see i…

This study tests two different ways to program an implantable defibrillator (ICD) to stop dangerous fast heartbeats. About 4,000 people with heart disease who need an ICD will be assigned to one of two pacing patterns (burst or ramp) and followed for up to 10 years. The goal is t…

This study will enroll 404 people with severe leakage in both the mitral and tricuspid heart valves. Participants will be randomly assigned to have either both valves repaired at once using a catheter-based device, or only the mitral valve repaired. The goal is to see which appro…

This study tests whether taking vitamin B supplements before and after heart surgery can lower the chance of serious problems like heart attack, stroke, or irregular heartbeat. About 1,000 adults having heart surgery will take either vitamin B or a placebo daily for 6 months afte…

This study looks at whether a medical-grade smartwatch (CardioWatch 287-2) can improve a 13-week virtual cardiac rehab program for people with heart disease. About 216 participants will either use the watch or not, and researchers will compare their progress in areas like exercis…

This study tests a new heart valve (SAPIEN X4) in 125 people with mitral valve disease who are too high-risk for open-heart surgery. The valve is placed using a thin tube through a blood vessel, avoiding major surgery. The goal is to see if the valve is safe and improves heart fu…

This early study will test a new polymer artificial heart valve in 10 people aged 60 or older with severe mitral valve disease. The goal is to see if the valve is safe and can be implanted successfully. Researchers will track deaths, reoperations, and how well patients can walk a…

This study tests a new device called DragonFly M2 to repair leaky mitral valves in people with moderate-to-severe or severe mitral regurgitation who are at high risk for surgery. The device is inserted through a blood vessel, avoiding open-heart surgery. The study will check if t…

This study tests a device called DragonFly that clips a leaky mitral valve shut, helping blood flow properly in people with heart failure. About 148 adults with moderate-to-severe or severe functional mitral regurgitation who still have symptoms despite medication will be randoml…

This study tests whether a minimally invasive heart valve repair procedure (TEER) plus standard medication can reduce hospital readmissions over two years in people with moderate mitral regurgitation that worsens with exertion. About 300 participants will be randomly assigned to …

This study tests Mobili®, a portable digital dispenser that automatically gives the right pills at the right time. Researchers will enroll 96 adults with diabetes or heart disease who take at least two daily medications. Participants use the device for a period, and the study mea…

This study tests a new device called the HighLife TSMVR system for people with severe mitral regurgitation, a condition where the heart's mitral valve leaks. The device is placed through a catheter via a vein, avoiding open-heart surgery. The trial will include 240 participants w…

This study tests a new radioactive tracer called 18F-FAPI-74 that may help detect scar tissue (fibrosis) in the heart and lungs earlier than current methods. Researchers will compare this new PET/CT scan to standard imaging in 210 adults with conditions like lung disease or heart…

This study tests a small, handheld ECG device that records heart activity when held against the chest and sends the data via smartphone to a doctor. Researchers will enroll 594 adults with known or suspected heart conditions to see if the new device is as good as the standard 10-…

This study tests a new cardiac MRI method called Free-Running Framework (FRF) that lets patients breathe normally and skips the sticky ECG electrodes. It captures a 3D image of the whole heart in one go, potentially making scans faster and more comfortable. Researchers will compa…

This study will check if a fast, bedside heart ultrasound performed by emergency doctors or interpreted by artificial intelligence can accurately detect heart problems in children who already have heart disease. About 200 children aged 0-21 will be included. The results will be c…

This study tests whether placing soft foam dressings on the skin before heart surgery can prevent pressure injuries (bedsores). About 80 adults having long heart surgeries will be enrolled. Researchers will check for new skin injuries after surgery and track how severe they are. …

This pilot study explores whether non-drug strategies like virtual reality or relaxing soundscapes can reduce anxiety and pain in adults undergoing scheduled coronary angiography or angioplasty. Participants will be assigned to listen to calming sounds, experience a virtual reali…

This study tests whether low-intensity focused ultrasound (LIFU) applied to a nerve cluster in the neck can improve sleep quality and heart rate control in people recovering from heart surgery. 200 participants will receive either real or sham ultrasound daily for 3-7 days after …

This study looks at whether a supplement called Neurofast® can help people who have both anxiety and heart problems. 80 adults aged 18-70 will take the supplement or no extra treatment for 12 weeks. Researchers will measure changes in anxiety, heart rate, and blood pressure.

This study tests whether adding a short, guided mindfulness meditation session to standard cardiac rehabilitation can help heart patients feel better and control their blood pressure. Eighty adults with heart disease will be split into two groups: one gets standard rehab plus med…

This study will compare cannabis, opioids, and two non-drug therapies (MIRE and TENS) in 1,000 people with chronic pain or circulatory disorders. The goal is to find safer, less addictive pain relief options. Researchers will measure changes in pain and nerve function using objec…

This study compares two sedatives, remimazolam and midazolam, to see which one causes less confusion (delirium) after heart valve surgery in people aged 65 and older. Delirium affects up to 70% of older heart surgery patients and can lead to longer hospital stays and memory probl…

This study compares two types of heart valve surgery: a newer, less invasive method through a small cut on the right side of the chest versus the traditional method through a cut down the middle of the chest. Researchers will measure how quickly patients recover, including time o…

This study will take standard heart CT scans from 1000 adults with structural heart disease and use a super-computer to create ultra-high-resolution images. The goal is to see if these enhanced images show more detail than the originals. No new treatments are being tested; it's a…

This study uses advanced 4D MRI scans to measure blood flow and heart function in adults with heart disease or cancer. Researchers aim to see if these detailed images can help predict how these diseases will progress. The study involves 1,000 participants who are already schedule…

This study will interview 15 people from ethnic minority backgrounds in the UK who have heart disease. The goal is to understand their views on the diet and lifestyle advice they get from doctors, and whether it fits their cultural and religious customs. Researchers hope to learn…

This study tests whether it is possible to run a larger trial comparing two ways of using a breathing machine (ventilator) in critically ill heart patients who need help breathing. The two modes are volume-controlled (delivers a set amount of air each breath) and pressure-control…

This observational study at a French hospital will ask 20 heart rehab patients and their care teams about what stops them from getting or offering psychological and social support. The goal is to understand these barriers so that hospitals can better help patients return to work …

This study will follow 5,500 people in China who receive new heart valve devices (replacement or repair) for conditions like aortic stenosis or mitral regurgitation. Researchers will track safety issues such as stroke, bleeding, and device function over time. The goal is to see h…

This study will test a new ultrasound catheter called VeriSight Pro that takes pictures from inside the heart. Doctors will use it during procedures like closing a hole in the heart or fixing a valve. The goal is to see if it helps guide these procedures safely and effectively. A…

This pilot study will test whether a women-focused education program, called Cardiac College for Women, helps women with heart disease learn more about their condition and feel better. About 50 women in cardiac rehab across Canada will either get the program plus usual care or us…

This study will look at how consistently nearly 6,000 adults in Italy take three newer cholesterol-lowering drugs (inclisiran, evolocumab, and alirocumab) over the long term. Researchers will analyze prescription records to measure adherence and persistence in everyday medical pr…

This study will test new MRI methods to find early signs of heart disease in 1000 adults. Researchers want to see if these scans can detect tiny changes in heart muscle before standard tests do. Participants will have MRI scans and blood work, but no treatment is given. The goal …

This study will test a simple score to predict which patients may become confused (delirium) after planned heart surgery. About 100 adults will be checked before surgery using memory, orientation, and frailty tests. The goal is to identify high-risk patients early so doctors can …

This large registry study will follow over 2,700 postmenopausal women aged 45-75 who use newer forms of hormone replacement therapy (creams, gels, sprays). The goal is to see if these modern delivery methods lower the risk of heart attacks, strokes, and other cardiovascular event…

This study will follow 4,000 intensive care patients aged 80 and older to see how chronic and acute heart conditions impact their survival, daily function, and quality of life. Researchers will use simple tests to measure frailty and independence. The goal is to help doctors bett…

This study will implant a small heart monitor under the skin of 100 people with moderate-to-severe mitral valve regurgitation who have few or no symptoms. The device will track heart rhythms for up to three years to find hidden atrial fibrillation that standard tests might miss. …

This study will follow 500 Beijing residents aged 60 and older to see how urinary function (like bladder and kidney health) relates to the development of multiple chronic conditions such as diabetes, heart disease, and Alzheimer's. Participants will have regular health checks, bl…

This pilot study will follow 90 men aged 18-50 who need heart surgery, some of whom will take the blood thinner warfarin afterward. Researchers will track changes in sperm count, movement, shape, DNA health, and hormone levels over 12 months. The goal is to see if warfarin harms …

This study will collect information from 15 patients in Asia-Pacific who have had or will have a less invasive procedure to fix a failed mitral or tricuspid heart valve. The goal is to learn how well these procedures work in this population, since most existing data comes from We…

This study will ask 380 heart patients and healthcare workers at Assiut University Heart Hospital to fill out questionnaires about depression, anxiety, stress, and burnout. No treatments or changes are given—the goal is simply to find out how common these mental health problems a…

This study aims to create an artificial intelligence (AI) model that analyzes ultrasound videos of the heart to help doctors decide if a patient with a leaky mitral valve (mitral regurgitation) is a good candidate for a minimally invasive repair procedure called TEER. The researc…

This study will follow 6,000 people in China who have both coronary heart disease and a leaky heart valve (ischemic mitral regurgitation). Researchers will collect medical data and track outcomes like hospitalizations and deaths over two years. The goal is to understand the disea…

This study will test whether an artificial intelligence (AI) system can detect pulmonary hypertension and other heart diseases using a smart stethoscope. Researchers will collect heart sound and ECG recordings from 1,000 adults already scheduled for routine echocardiography. The …

This study looks at how sleep disorders and problems with the body's automatic functions (like heart rate control) are linked in elderly people with heart disease. Researchers will study 210 patients aged 65 and older to find out how common sleep issues are and how they affect he…

This study will compare two ways of measuring pressure inside the heart during heart surgery: the gold standard (direct left atrial pressure) and a more common indirect method (pulmonary capillary wedge pressure). Researchers want to see if the indirect method is accurate enough …

This study looks at 300 people with severe mitral regurgitation who need heart surgery. Researchers want to see if a special ultrasound technique called speckle tracking can better predict who will do well after surgery, compared to the current standard method. The study only use…