Invasive breast carcinoma

Researchers are testing whether a device called ExAblate MRgFUS can safely and completely destroy small breast cancers using focused ultrasound waves guided by MRI. The trial enrolls women with a single invasive breast tumor smaller than 2 centimeters who are already scheduled fo…

This phase III trial compares two radiation schedules for women with high-risk breast cancer who have had a mastectomy. One group receives hypofractionated radiation, which uses fewer but larger daily doses over a shorter period. The other receives conventional radiation, with sm…

This trial asks whether women with early breast cancer who have lumpectomy and whole-breast radiation can safely skip the sentinel lymph node procedure, a biopsy of the first lymph node under the arm. The procedure helps check if cancer has spread, but it can cause arm swelling a…

This trial tests two drugs, degarelix and triptorelin, in premenopausal women with hormone-sensitive breast cancer. Both drugs temporarily stop the ovaries from making estrogen, which can fuel tumor growth. Women receive one of the drugs along with the hormone therapy letrozole f…

This phase II trial tested the drug alisertib, alone or combined with fulvestrant, in 96 postmenopausal women with advanced breast cancer that no longer responds to hormone therapy. Alisertib blocks enzymes that help cancer cells grow, while fulvestrant blocks estrogen. The goal …

This phase III trial asks whether adding bevacizumab to standard hormone therapy (tamoxifen or letrozole) helps women with hormone receptor-positive advanced breast cancer live longer without the disease worsening. Hormone therapy blocks estrogen, which fuels tumor growth, while …

This trial tests whether a 3D imaging device, used during lumpectomy surgery, can help surgeons see and remove all cancerous tissue while the patient is still in the operating room. The goal is to reduce the chance of leaving cancer cells behind, which often leads to a second sur…

This trial is testing whether choosing chemotherapy based on the genetic profile of a patient's breast tumor can improve treatment response compared to standard chemotherapy. Women with HER2-negative breast cancer that is not eligible for conservative surgery will be randomly ass…

This trial is testing whether a radioactive tracer, technetium Tc 99m sulfur colloid, can accurately locate sentinel lymph nodes in women with early-stage breast cancer. The sentinel node is the first lymph node cancer is likely to spread to, and finding it helps guide surgery. T…

This study tests a precise type of radiation called proton therapy for women who have had a mastectomy for invasive breast cancer. Unlike standard radiation, proton beams stop at the target area, potentially reducing damage to nearby organs like the heart and lungs. The goal is t…

This phase II trial studied 92 women with early-stage breast cancer to see how well chemotherapy (paclitaxel and cyclophosphamide) with or without trastuzumab works before surgery. The main goals were to check side effects and see if the tumor disappears completely by the time of…

This large phase III trial tests which of three chemotherapy drugs—paclitaxel, nab-paclitaxel, or ixabepilone—works best, with or without the targeted drug bevacizumab, for people with stage IIIC or IV breast cancer that has returned or spread. The study aims to find the most eff…

This study looked at whether a special needle device (vacuum-assisted biopsy) can completely remove small breast cancers using ultrasound guidance, instead of traditional surgery. 45 women with small, early-stage breast cancers participated. The goal was to see if this less invas…

This phase 2 study looked at women with invasive breast cancer who had a mastectomy with immediate prosthetic breast reconstruction, followed by TomoTherapy (a type of radiation) with or without chemotherapy. The goal was to see how often the reconstruction was successful. 66 pat…

This phase II trial tested giving a higher dose of radiation over fewer sessions (hypofractionated radiotherapy) to the whole breast before surgery in 25 women with early-stage breast cancer. The goal was to see if this approach could kill more tumor cells and cause fewer side ef…

This study tested a combination of enzalutamide (a hormone blocker) and paclitaxel (chemotherapy) given before surgery to 24 people with a specific type of triple-negative breast cancer that has androgen receptors. The goal was to see if this treatment could shrink tumors and red…

This early-phase study tested a vaccine made from patients' own immune cells to target HER2-positive breast cancer. 31 participants with stage II or III breast cancer received the vaccine alongside standard chemotherapy before surgery. The goal was to see if the vaccine could boo…

This study looked at how well older adults (70+) with advanced, hormone-sensitive breast cancer tolerate a combination of palbociclib and either letrozole or fulvestrant. The goal was to see if the treatment is safe and effective in this age group. 93 participants were enrolled, …

This study tested a type of breast cancer surgery called nipple-sparing mastectomy, where the breast tissue is removed but the nipple and skin are kept. It involved 450 women with early-stage breast cancer who needed a full mastectomy. The goal was to see if this surgery keeps th…

This phase 2 trial tested whether adding the drug veliparib to standard chemotherapy (cisplatin) helps people with metastatic triple-negative or BRCA-related breast cancer, including those with brain metastases. The study enrolled 344 participants to see if the combination slows …

This study tested whether injecting a modified herpes virus (T-VEC) directly into tumors, alongside standard chemotherapy before surgery, could better eliminate triple negative breast cancer. The virus is designed to infect and destroy cancer cells while leaving healthy cells alo…

This study tested a combination of chemotherapy (nab-paclitaxel) and immunotherapy (atezolizumab) given before surgery to women with triple-negative breast cancer. The goal was to shrink tumors and reduce the amount of breast tissue that needs to be removed. The trial involved 37…

This early-phase study tested two drugs, abemaciclib and niraparib, given together before surgery in 8 people with hormone receptor-positive, HER2-negative breast cancer. The goal was to find the best dose and see if the combination could shrink tumors safely. The study focused o…

This study looked at 720 women with early-stage breast cancer who had a lumpectomy. They were split into two groups: one got standard daily radiation for several weeks, the other got a shorter course of higher-dose radiation. The goal was to see if the shorter treatment works jus…

This phase II trial tested a 9-day course of whole breast radiation (hypofractionated radiotherapy) in 102 patients with early-stage breast cancer (stage 0-IIB). The goal was to see if a shorter treatment time could maintain effectiveness while reducing side effects. Researchers …

This completed study tested whether a shorter, more intense course of radiation (1 week) works as well as the standard 3-week course for women with early breast cancer after lumpectomy. Sixty women were split into two groups to compare side effects, cosmetic results, and cancer c…

This study tested a new imaging dye called LS301-IT in 22 women with early-stage breast cancer (DCIS or stage I-II) who were having a partial mastectomy. The dye is injected into a vein before surgery to make cancer cells glow, helping surgeons see and remove them more accurately…

This study tested a new way to tell breast cancer types apart using a special ultrasound, instead of a tissue biopsy. Researchers looked at blood vessel patterns in tumors from 94 patients and built a tool to predict whether the cancer was luminal or non-luminal. The goal is to h…

This study tested whether a special PET/MRI scan using a tracer called FFNP can accurately measure progesterone receptors in invasive breast cancer. Twenty-one women with breast tumors at least 1 cm in size took part. The goal was to see if the scan results match the standard lab…

This study tested a new handheld gamma camera (CarolIReS) in 110 breast cancer patients to see if it could find sentinel lymph nodes that standard methods miss. The camera was used before and during surgery to guide removal and check if any nodes were left behind. The goal was to…

This study tests whether a special PET scan using a radioactive tracer called FES can accurately detect breast cancer that has spread to lymph nodes under the arm. Researchers will scan 71 people with estrogen-positive breast cancer and compare the results to standard methods. If…

This study explored whether breast cancer has a unique smell that can be detected. Researchers used a special polymer (Sorbstar®) and trained dogs to sniff samples from 35 women before and after tumor removal. The goal was to see if a distinct scent signature exists, which could …

This study tested whether contrast-enhanced mammography (CEM) can find more breast cancers than standard mammography in women already diagnosed with breast cancer. 89 women received CEM, which uses an iodine dye to highlight suspicious areas. The goal was to see if CEM detects ad…

This study follows up on women who took a low dose of tamoxifen (5 mg daily) for three years to see if it continues to prevent breast cancer over the long term. The original trial found a 42% reduction in breast cancer events. Researchers will also combine data from three similar…

Researchers at the University of Oklahoma are testing a mobile health program designed to help adults receiving chemotherapy for metastatic breast or gynecologic cancer stay physically active. The program combines a wearable activity tracker, behavior change techniques, acceptanc…

This study tested whether EMDR (a therapy using guided eye movements) could help reduce anxiety and depression in women with breast cancer. Fifteen women who had mastectomy for invasive breast cancer received up to 8 sessions of EMDR during their cancer treatment. The main goal w…

This study tested two behavioral programs—coping skills training and general health education—to see which better improves well-being in people with ongoing pain after breast cancer surgery. About 316 participants who had surgery for breast cancer or precancerous conditions took …

This study compared two types of nipple-sparing mastectomy for breast cancer: one done with a robot and the other with traditional open surgery. 82 women took part, and the main goal was to see which approach led to higher patient satisfaction. The trial also looked at recovery t…

This trial tested a new device called the Breast Cancer Locator (BCL), a custom plastic bra that helps surgeons find tumors during breast-conserving surgery. It was compared to the standard wire localization method in 480 women with non-palpable breast cancer. The goal was to see…

This study tested whether a nerve block using ropivacaine could reduce pain after breast cancer surgery compared to a placebo. 182 women having breast-conserving surgery with sentinel lymph node biopsy took part. The goal was to see if fewer patients needed strong painkillers in …

This study is looking at whether tracking tiny bits of tumor DNA in the blood can help predict if breast cancer will come back after chemotherapy and surgery. Researchers will take blood samples from 180 people every 6 months for 5 years. The goal is to see if these DNA clues can…

This completed Phase 2 trial looked at whether the sentinel lymph node technique—a less invasive way to check if cancer has spread—works for women with multifocal breast cancer (more than one tumor in the same breast). 216 women with early-stage, node-negative multifocal breast c…

This study looks at how doctors currently diagnose lung and breast cancer using tissue samples. It will also test whether artificial intelligence (AI) can help analyze these samples faster and more accurately. Researchers will review records from 600 patients to measure diagnosis…

This study gathers information from multiple hospitals about breast cancer in transgender and gender-diverse adults. Researchers want to understand how the cancer is found, what risk factors are involved, and how it is treated. The goal is to find ways to improve care and reduce …

This completed study analyzed tissue samples from 108 breast cancer patients to identify proteins linked to early cancer invasion. The goal was to find markers that could help assess the risk of tumor spread in patients without lymph node involvement. Researchers focused on listi…

This study measured levels of a protein called IP3R3 in breast cancer tissue from 42 women. The goal was to see if this protein is involved in how cancer cells migrate and invade nearby tissues. Researchers hope this could lead to better understanding of what makes breast cancer …

This study tested a combination of two methods—radioactive isotope and blue dye injection—to locate sentinel lymph nodes in 100 breast cancer patients. The goal was to see if using both together improves accuracy and cost-effectiveness. Researchers compared the results and analyz…

This study tested a custom-made device called the Breast Cancer Locator (BCL) in 35 women with non-palpable breast cancer. The device helps surgeons see exactly where the tumor is during breast-conserving surgery, with the goal of removing all cancer in one go and reducing the ne…

This completed study looked at ways to increase diversity in cancer clinical trials, focusing on breast, liver, and prostate cancers. Researchers worked with communities, doctors, and scientists in New York City to find better ways to include people of color and underserved group…

This study looked at whether a special, graph-based genetic counseling method helps newly diagnosed breast cancer patients better understand their risk of cancer in the other breast and make more informed surgery choices. About 400 patients participated, comparing this new approa…

This study looked at whether tiny molecules called microRNAs in the blood can help predict if hormone therapy will work for women with advanced breast cancer. Researchers tested blood samples from 39 women before and after one month of treatment with tamoxifen or an aromatase inh…

This completed study involved 775 women who had breast-conserving surgery and radiation for breast cancer. Researchers compared different surgery and radiation techniques to see which ones led to less breast hardening (fibrosis) and better cosmetic results. The goal was to find w…

This completed early study tested a special clip-on electrode with fiber optics that detects light signals during breast cancer surgery. The goal was to see if the device is safe and can help surgeons identify different tissue types in real time. Twenty-four women with invasive b…

This study looked at how to better educate women with breast cancer about sexual health during treatment. Researchers held focus groups with 93 patients to understand their needs and preferences. The goal was to create educational materials that could improve sexual well-being th…

This study looked at how breast cancer treatments affect sexual health in 25 women. Participants filled out anonymous questionnaires about their sexual function, quality of life, and emotional well-being before and after chemotherapy. The goal was to understand how these factors …

This study tested whether a high-resolution PET-CT scan of the removed tumor during breast-conserving surgery can help surgeons see if any cancer cells remain at the edges. About 206 women with early-stage breast cancer received a low-dose radioactive tracer before surgery. After…

This study looked at how DNA from tumors changes in the blood before, during, and after surgery for breast, prostate, or colon cancer. Thirty adults having curative surgery provided blood samples to measure these DNA levels. The goal was to understand the natural pattern of DNA c…

This study tested a noninvasive imaging method called Diffuse Optical Spectroscopy Imaging (DOSI) to see if it could predict how breast cancer responds to chemotherapy. Twenty-four women with breast cancer were scanned up to 9 times during their treatment. The goal was to see if …

This study looked at whether MRI scans can detect how well breast cancer responds to chemotherapy early in treatment. Sixteen women with invasive breast cancer received standard chemo before surgery, and their MRI results were checked by two radiologists. The goal was to see if M…

This study looked at the DNA of breast tumors from 140 patients to understand why some cancers are destroyed by standard chemotherapy and others are not. Researchers analyzed genetic changes in the tumors and compared them to normal DNA. The goal is to find new drug targets and i…