Gastroesophageal reflux disease

This registry follows 500 adults who receive the LINX device, a ring of magnetic beads implanted around the esophagus to help keep stomach acid down. The goal is to check for safety issues like device movement, erosion, or swallowing problems over up to 10 years. Participants wil…

This study tests whether a structured program of dietary changes, lifestyle adjustments, and nutrient correction can reduce reflux symptoms in patients who had POEM surgery for achalasia. Many patients develop GERD after POEM and rely on long-term acid-reducing medications. The t…

This study was designed to see if a new drug called linaprazan glurate could keep the esophagus healed in people with GERD-related erosive esophagitis, compared to an existing drug (lansoprazole). Participants would have taken daily pills for up to 52 weeks and had regular camera…

This study is testing a new device called the Edwards EVOQUE system, which replaces the tricuspid valve using a thin tube (catheter) instead of open-heart surgery. The trial includes 228 people with moderate or severe tricuspid regurgitation who still have symptoms despite medica…

This phase 3 study tests two doses of Nexium (esomeprazole) in 53 children aged 1 to 11 years who have erosive esophagitis, a condition where stomach acid damages the esophagus. The goal is to see which dose better maintains healing after an initial 8-week treatment period. Child…

This study looks at whether adding a small bypass (gastroenteroanastomosis) to the standard sleeve gastrectomy can prevent or reduce acid reflux in people with obesity. Sixty patients will be split into two groups: one gets the added bypass, the other does not. Researchers will c…

This study tests a new device called the Edwards EVOQUE eos mitral valve replacement system. It is for people with a leaky mitral valve who are too high-risk for open-heart surgery. The study will check if the device is safe and works well by looking at complications, heart funct…

This study tracks the safety and effectiveness of a procedure called TIF 2.0, which tightens the valve between the stomach and esophagus without any cuts. About 500 adults with acid reflux or throat reflux will be followed to see if their symptoms improve and if they can reduce o…

This study tests whether injecting platelet-rich plasma (PRP) during hiatal hernia repair can lower the chance of the hernia coming back. About 150 adults with large hiatal hernias will be randomly assigned to get either standard surgery with mesh or surgery plus PRP. The main go…

This study is testing a new combination treatment for non-erosive reflux disease (NERD), a common form of GERD that causes heartburn and other symptoms. The treatment adds therapies to strengthen the esophagus's natural barrier on top of standard acid-reducing medication. Researc…

This small study tests an endoscopic procedure that uses band ligation to tighten the lower esophagus and upper stomach, aiming to reduce acid reflux in people who had gastric sleeve surgery. Twelve participants will undergo the procedure and be monitored for six months to see if…

This early study tests a small, permanent device called the Omega-Cuff in 8 adults with GERD. Placed around the weak esophageal sphincter during keyhole surgery, it aims to block acid from backing up while allowing food to pass normally. Researchers will check safety, acid levels…

This study is testing a new, less invasive device that measures the health of the esophagus in people with acid reflux (GERD). Researchers will compare two versions of the device in 75 patients undergoing routine endoscopy. The goal is to see if this technology can diagnose GERD …

This study tests whether a 4-week course of vonoprazan, a stronger acid blocker, can help identify which patients with persistent heartburn actually have acid reflux. About 100 adults with symptoms that don't improve on standard treatment will take the drug and complete symptom q…

This study looks at whether feeding preterm babies (weighing less than 3.3 pounds) through a tube placed past the stomach can prevent small amounts of stomach fluid from getting into their lungs. The goal is to reduce lung inflammation. About 46 babies on breathing machines will …

This study looks at whether speech therapy can reduce air-related symptoms like belching and bloating in people with GERD. Researchers will compare symptoms before and after therapy in 100 adults. The goal is to see if speech therapy can help patients avoid antireflux surgery, wh…

This study looks at three ways to manage pain during and after laparoscopic Nissen fundoplication (a surgery for acid reflux). About 63 adults will receive either a spinal injection of morphine, a spinal injection of fentanyl, or morphine through an IV. Researchers will measure t…

This study tests whether a daily medicine called dexlansoprazole can safely reduce symptoms of gastroesophageal reflux disease (GERD) in children aged 2 to 11 years who have heartburn but no damage to their esophagus. About 71 children will take the medicine or a placebo for 12 w…

This Phase 2 trial tests whether a prebiotic syrup called MHS-1031 (PIMO) can increase heartburn-free days when added to standard proton pump inhibitor (PPI) therapy for people with GERD. About 247 adults who still have heartburn despite taking PPIs will receive either the syrup …

This study planned to test a laparoscopic-guided nerve block (TAP block) to reduce opioid painkiller use after weight-loss or anti-reflux stomach surgeries. It compared two numbing medicines, Bupivacaine HCL and Exparel. However, the trial was withdrawn before enrolling any parti…

This program allows people aged 12 and older with severe stomach or gut problems, like gastroparesis, to try domperidone when standard treatments have failed. The goal is to ease symptoms such as nausea, vomiting, and severe indigestion. The drug is not FDA-approved but is availa…

This study tests whether the Gracie Diet can reduce symptoms of gastroesophageal reflux disease (GERD) in adults who want to stop taking standard acid-reducing drugs. About 30 participants will stop their medication and follow the diet for 8 weeks. Researchers will track symptom …

This study looks at two ways to remove small throat patches (inlet patches) that can cause discomfort in people with GERD. About 72 participants will receive either argon plasma or radiofrequency ablation. The goal is to see which method patients find more comfortable and which w…

This study aims to find early DNA changes in blood and esophageal tissue that could signal a higher risk of developing esophageal cancer. Researchers are studying 600 people with gastroesophageal reflux, Barrett's esophagus, or esophageal cancer who are already scheduled for an u…

This study follows 250 obese adults who are having a weight-loss procedure—either surgery or an endoscopic stomach reduction. The goal is to see how often acid reflux (GERD) develops afterward, including silent reflux with no symptoms. By tracking symptoms and using tests, resear…

This study looks at 200 male FDNY rescue workers who were exposed to dust and toxins after the World Trade Center attacks. Many developed acid reflux, which can lead to Barrett's esophagus and even cancer. Researchers will use simple, noninvasive tests like saliva samples and que…

This study is a registry that will review medical records of 1,000 patients treated for benign or malignant gastrointestinal diseases between 2005 and 2030. Researchers will look at survival, symptoms like heartburn and swallowing trouble, and quality of life. The goal is to lear…

This study follows 2,500 people with gastroesophageal reflux disease (GERD) to compare how well medications and surgery work over time. Researchers will track quality of life, heartburn symptoms, and patient satisfaction. The goal is to identify who benefits most from each treatm…

This pilot study is looking at whether dental erosion (loss of tooth enamel) could be a non-invasive biomarker for esophagogastric cancer and other cancers. Researchers will survey 174 participants (cancer patients and healthy volunteers) about diet, habits, and GERD symptoms, an…

This study is not testing a new treatment. Instead, it follows 500 people who already had a procedure called TIF (transoral incisionless fundoplication) for acid reflux. Researchers will collect data from medical records to see how symptoms and quality of life change over time. T…

This study follows 200 patients who had minimally invasive surgery for conditions like achalasia, GERD, or hiatal hernia. Each year, patients fill out questionnaires about their symptoms and quality of life, and doctors review their medical records. The goal is to understand how …

This study is creating a large registry of 2,000 people with gastroesophageal reflux disease (GERD) and related conditions like Barrett's esophagus. Researchers will collect data from medical records and questionnaires over 5 years to better understand the disease and its treatme…

This study tracks 500 adults with conditions like acid reflux, achalasia, or complications after weight-loss surgery. Participants choose either a newer endoscopic procedure (done through a scope) or standard surgery. Researchers will compare how well each approach controls sympt…

This study collects blood, urine, and tissue samples from 500 obese adults to help researchers understand why people gain weight, lose weight, or regain weight after treatment. Participants must be over 18 with a BMI of 30 or higher. The samples will be stored for up to 10 years …

This study aimed to develop better diagnostic tests and a device (external pressure on the throat) for patients with pharyngeal reflux, where stomach contents reach the throat. It planned to include adults with GERD and throat symptoms. However, the study was withdrawn before enr…

This study follows 75 people who had either sleeve gastrectomy or gastric bypass for severe obesity. Researchers track acid reflux symptoms, esophageal damage, and other measures for 8 years using tests like endoscopy and pH monitoring. No new treatments are given—it's purely obs…

This study surveys over 3,700 medical students and interns across the Middle East to find out how many have gastroesophageal reflux disease (GERD). It also looks at how eating habits, stress, anxiety, and depression relate to GERD and how the condition affects their quality of li…

This study followed 64 adults who had laparoscopic sleeve gastrectomy (a common weight-loss surgery) to see how acid reflux symptoms changed. Researchers compared those who had reflux before surgery with those who did not. They used a standard questionnaire to measure heartburn a…