Gastroesophageal reflux disease
MONDO:0007186A chronic disorder characterized by reflux of the gastric and/or duodenal contents into the distal esophagus. It is usually caused by incompetence of the lower esophageal sphincter. Symptoms include heartburn and acid indigestion. It may cause injury to the esophageal mucosa.
Also known as: GERD, acid reflux, gastroesophageal reflux, gastroesophageal reflux disease, gastroesophageal reflux, paediatric, gastroesophageal reflux, pediatric, ger
185 clinical trials for this condition and its sub-types.
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Broader categories
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New device zaps away acid reflux – but is it safe Long-Term?
Disease control TerminatedThis study tracked 350 people with GERD who received a device that electrically stimulates the muscle that keeps stomach acid from rising. The goal was to see how safe the device is over 5 years and whether it improves symptoms and quality of life. The registry included both new …
Sponsor: EndoStim Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:32 UTC
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New combo surgery for obesity and reflux tested – but study stopped early
Disease control TerminatedThis study aimed to compare a standard sleeve gastrectomy (removing part of the stomach) with a modified version called N-Sleeve, which adds a wrap around the top of the stomach to prevent acid reflux. The trial was designed for people with severe obesity and GERD, but only 2 pat…
Phase: NA • Sponsor: University Hospital, Montpellier • Aim: Disease control
Last updated Jun 27, 2026 07:53 UTC
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Sleep apnea machine tested for IPF lung health – but study stopped early
Knowledge-focused TerminatedThis study looked at whether using a CPAP machine at night could reduce abnormal acid reflux and lung inflammation in people with idiopathic pulmonary fibrosis (IPF) who also have sleep apnea. Only 7 people enrolled before the study was terminated early. The goal was to measure c…
Phase: NA • Sponsor: University of Arizona • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:00 UTC
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Which surgery keeps hiatal hernias away longer? study aims to find out
Knowledge-focused TerminatedThis registry tracked 336 adults who had surgery for a large hiatal hernia (over 3 cm) at least two years earlier. Some received a LINX magnetic implant to strengthen the valve between the stomach and esophagus, while others had a fundoplication (wrapping the stomach around the e…
Sponsor: Foregut Research Foundation • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:03 UTC