Duodenogastric reflux

This study tests whether a Botox injection into the stomach valve works as well as a surgical cut to prevent food from emptying too slowly after esophagus removal. About 170 adults having elective esophagectomy will be randomly assigned to one of the two procedures. Researchers w…

This study tests a magnetically controlled capsule endoscope—a tiny camera you swallow—to painlessly screen the esophagus and stomach. Researchers will compare different swallowing protocols to see which gives the best view of the Z-line and other areas. 300 patients already sche…

This study compares using one doctor versus two doctors to perform a procedure called single-balloon enteroscopy, which looks deep into the small intestine. About 228 adults with suspected small bowel disease will be randomly assigned to either technique. The goal is to see if on…

This study aims to collect medical data and biological samples (blood, urine, stool, and tissue) from up to 4,000 adults with known or suspected gastrointestinal diseases. Participants receive standard medical care at the NIH, and any extra samples or leftover tissue from procedu…

This study compares two techniques—esophageal manometry and EndoFLIP balloon measurements—to evaluate how well they assess swallowing difficulties (dysphagia). Researchers will enroll up to 1,000 patients with known esophageal conditions to see how these measurements relate to sy…

This study tests whether using a predictive model before a double-balloon enteroscopy helps doctors fully examine the small intestine. About 338 adults with suspected small-bowel disease will be randomly assigned to have their doctor see the model score or not. The main goal is t…