Flaviviridae infectious disease

This Phase 1 trial tested a new live-attenuated dengue vaccine in 127 healthy adults aged 18 to 59. The goal was to see how safe the vaccine is and how the immune system responds, especially in people who have had dengue before. Participants received one shot and were monitored f…

This Phase 3 trial tested Takeda's dengue vaccine (TDV) in 480 healthy people aged 4 to 60 in India. Participants received two doses of either the vaccine or a placebo, three months apart. The main goals were to check for side effects and measure the body's immune response agains…

This early-stage trial tested two new vaccines—one for yellow fever and one for rabies—in 112 healthy adults aged 18 to 40. The main goal was to check safety and see how well the vaccines trigger an immune response. Participants received different doses or a placebo to help find …

This early-stage trial tested an inactivated Zika virus vaccine (VLA1601) in 150 healthy adults aged 18-49. Participants received two doses, and researchers monitored side effects and immune responses. The goal was to find the safest and most effective dose, including combination…

This early-stage study tested a new yellow fever vaccine (MVA-BN-YF) in 92 healthy adults aged 18-45. Some volunteers received the vaccine alone, some with an adjuvant (ISA 720) to boost the immune response, and others received a placebo or a different vaccine. The main goal was …

This study tested a new yellow fever vaccine (vYF) to see if it is as safe as the current licensed vaccine (YF-VAX). A total of 640 healthy adults aged 18 to 60 received a single shot of either vaccine. Researchers monitored side effects like pain, fever, and headache for about 6…

This study tested a yellow fever vaccine in 254 healthy adults aged 18 and older in Japan. Participants received one shot under the skin and were followed for about a month. The goal was to see if the vaccine triggers a strong immune response and is safe.

This pilot study tested whether giving the Qdenga dengue vaccine into the skin (intradermal) works as well as the standard shot under the skin. 29 healthy Thai adults who had never received a dengue vaccine took part. Researchers measured antibody and T-cell levels at day 0, 30, …

This study tested a dengue vaccine (TDV) in 187 healthy Japanese volunteers aged 4 to 60. Participants received two shots three months apart. The main goal was to see if the vaccine triggers an immune response against all four types of dengue virus. The trial is now complete.

This study tested a new dengue vaccine in over 20,000 healthy children aged 4 to 16 years. The goal was to see if two doses could prevent dengue fever caused by any of the four dengue virus types. The vaccine was given as a shot under the skin and compared to a placebo. Results s…

This study tested a new dengue vaccine called V181 against an existing one (Butantan-DV) in 1,364 healthy adults aged 18 to 50 in Brazil. The goal was to see if V181 is as safe and triggers a similar immune response. Results showed V181 was safe and produced comparable antibody l…

This study tested Moderna's experimental Zika vaccine, mRNA-1893, in 808 healthy adults aged 18 to 65. Participants received one of two doses or a placebo, and researchers monitored side effects and immune responses. The goal was to confirm the vaccine's safety and ability to pro…

This Phase 1 study tested a new yellow fever vaccine (vYF) in 73 healthy adults aged 18 to 60. The goal was to check the vaccine's safety and how well it triggers an immune response at three different doses. Participants were monitored for side effects and antibody levels over si…

This Phase 1 trial tested an inactivated yellow fever vaccine called HydroVax-002 YFV in 26 healthy adults. Participants received two doses of either the vaccine or a placebo. The main goal was to check safety and side effects, while also measuring immune response. The trial is c…

This phase 2 trial tested a tetravalent dengue vaccine (TDV) in 30 healthy adults, some with prior dengue exposure and some without. The goal was to measure the body's immune response and check for safety. Participants received a single shot, and researchers tracked antibody leve…

This study tested whether an extract from papaya leaves (CPLE) can help people with dengue fever. 250 adults with confirmed dengue were given either CPLE capsules or a placebo for 5 days. The main goals were to see if the extract could raise platelet counts and reduce the risk of…

This study tested a new drug called AV-1, which is a lab-made antibody, to see if it can prevent or treat dengue virus type 3 infection. Eighty-five healthy adults received either a low, medium, or high dose of AV-1 or a placebo, and were then exposed to a controlled dengue virus…

This study looked at whether giving hospital-level care to acutely ill adults in their own homes in rural areas works well. 160 people with various conditions like infections, heart failure, or COPD took part. The goal was to see if this approach could lower costs and help patien…

This study tested whether a drug called fenretinide (ISLA101) can prevent or reduce dengue symptoms. Fifteen healthy adults were given either the drug or a placebo before or after being exposed to a weakened dengue virus. Researchers measured virus levels and immune responses ove…

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This early study tested whether a special PET scan using a radioactive form of vitamin B9 (11C-PABA) can help doctors see infections deep inside the body. Researchers scanned 13 healthy people and patients with known or suspected infections. The goal was to see if this method can…

This study tested whether sending health tips via WhatsApp could help families in Colombia prevent dengue, Zika, and chikungunya. About 900 households were split into three groups: one got WhatsApp messages plus community support, one got community support only, and one got routi…

This study tested whether smaller doses of the yellow fever vaccine are as safe and effective as the standard dose. Researchers gave 88 healthy adults either the full dose or a reduced dose (one-fifth or one-tenth the size). They monitored side effects and measured immune respons…

This study looked at whether a single dose of the TV003 dengue vaccine or a past Zika infection could protect people from getting infected with Zika virus again. 27 healthy adults took part. Researchers gave them the vaccine or used people who had Zika before, then exposed them t…

This study tested a clever way to prevent dengue fever: releasing mosquitoes infected with Wolbachia bacteria into neighborhoods in Brazil. Over four years, researchers compared areas that got these special mosquitoes plus usual control methods to areas with usual methods alone. …

This study tested whether spraying insecticide on indoor walls (Targeted Indoor Residual Spraying) can prevent diseases spread by Aedes mosquitoes, like dengue, chikungunya, and Zika. Over 4,400 children aged 2 to 15 in Merida, Mexico took part. Researchers tracked how many got s…

This large study tested a device called Mosquito Shield that releases a repellent (transfluthrin) to keep mosquitoes away. Nearly 7,000 children aged 4-16 in Sri Lanka took part. The goal was to see if the device reduces infections from viruses like dengue. Researchers tracked in…

This study followed 775 healthy children aged 2-9 in Cambodia over three years to learn how mosquitoes spread dengue and other viruses. Researchers took blood samples every wet and dry season to check for past or current infections. The goal was to understand why young children g…

This study looked at 150 people with dengue fever to see if abdominal ultrasound findings, like gallbladder thickening or fluid in the belly, are linked to low platelet counts—a sign of severe disease. Researchers reviewed medical records and ultrasound images to find patterns th…

This completed study tested whether machine learning could predict dengue and severe dengue using electronic health records from 1,000 patients in Thailand and Vietnam. The goal was to create a low-cost tool that works even when lab tests are unavailable. Researchers used vital s…

This study reviewed the medical records of 199 patients with severe dengue who were treated in intensive care units in Villavicencio, Colombia. Researchers looked at patient details, lab results, and outcomes to better understand the disease in a real-world ICU setting. No new tr…

This study looked at how people's immune systems react to proteins in mosquito saliva after being bitten. Researchers exposed 147 healthy adults in Thailand to lab-grown mosquitoes that can carry malaria or dengue. The goal was to find markers in the blood that show how much expo…

This study tested whether playing an educational board game could improve nurses' knowledge, attitudes, and confidence about dengue compared to a standard lecture. Over 100 nurses from 14 health centers in Indonesia took part, each receiving a single 90-minute session of either t…

This pilot study looked for dengue virus in the sperm of 10 men with active dengue infection. Researchers collected semen, urine, and blood samples over 90 days to see if the virus is present and where it hides. The goal is to understand if the virus can be in sperm and whether s…

This study looked at 156 critically ill patients to find out what factors help achieve the right levels of beta-lactam antibiotics in the blood. Researchers collected clinical data and used therapeutic drug monitoring to see which patients reached target concentrations. The goal …

This completed study observed nearly 27,000 pregnant women in French Caribbean departments during the 2016 Zika epidemic. Researchers tracked Zika infections and their impact on pregnancy, including rates of microcephaly and other fetal abnormalities. The goal was to better under…

This study looked at how past infections and damage to lymph node structures might weaken the body's long-term immune response to the yellow fever vaccine. Researchers enrolled 43 healthy adults in Uganda and Minnesota, collecting blood and lymph node samples before and after vac…

This study gave 239 healthy adults the yellow fever vaccine to learn how the immune system fights viral infections. Researchers measured the strength and quality of T cell responses over up to one year. The goal was to understand immune reactions, not to test the vaccine itself, …

This completed study surveyed 164 Sudanese adults to understand their awareness of dengue fever and how they try to prevent it during the ongoing war. Participants answered questions about symptoms, prevention, and healthcare access. The goal is to use these insights to improve d…