Could a smaller shot still shield against yellow fever?
NCT ID NCT05374317
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether smaller doses of the yellow fever vaccine are as safe and effective as the standard dose. Researchers gave 88 healthy adults either the full dose or a reduced dose (one-fifth or one-tenth the size). They monitored side effects and measured immune responses to see if the smaller doses could still protect against the disease.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Yellow fever vaccine (YF-VAX)
- What this could lead to
- If successful, using smaller vaccine doses could help protect more people during outbreaks or supply shortages.
- What could go wrong
- This is a small, early-phase study with only 88 participants, so results may not apply broadly. Lower doses might not provide enough protection.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
United States Army Medical Research Institute of Infectious Diseases
Frederick, Maryland, 21702, United States