Scientists probe why some vaccines fade: lymph node damage may be key
NCT ID NCT04269265
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at how past infections and damage to lymph node structures might weaken the body's long-term immune response to the yellow fever vaccine. Researchers enrolled 43 healthy adults in Uganda and Minnesota, collecting blood and lymph node samples before and after vaccination. The goal was to understand why some people lose protection over time, which could help improve future vaccines.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for YELLOW FEVER are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Joint Clinical Research Centre
Kampala, 10005, Uganda
-
University of Minnesota
Minneapolis, Minnesota, 55455, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- New yellow fever vaccine shows promise in Mid-Stage trial
- New vaccines for yellow fever and rabies enter first human tests
- New yellow fever vaccine shows promise in early human trial
- 10,000 people tested: Cambodia's massive disease hunt begins
- Scientists use yellow fever vaccine to map immune System's battle plan
- New yellow fever vaccine shows promise in early safety trial