Home spraying trial targets dengue, chikungunya, and zika in kids

NCT ID NCT04343521

Completed Prevention Sponsor: Emory University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested whether spraying insecticide on indoor walls (Targeted Indoor Residual Spraying) can prevent diseases spread by Aedes mosquitoes, like dengue, chikungunya, and Zika. Over 4,400 children aged 2 to 15 in Merida, Mexico took part. Researchers tracked how many got sick over three transmission seasons to see if the spraying reduced infections.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Targeted Indoor Residual Spraying (TIRS) with insecticide Actellic 300CS
What this could lead to: If effective, this spraying method could become a simple, low-cost way to prevent outbreaks of dengue, chikungunya, and Zika in high-risk areas.
What could go wrong: This is a completed trial, but results may not apply to other regions or mosquito species. The intervention requires residents to leave home briefly, which may not be practical everywhere.

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Conditions

The condition(s) this trial relates to.

Mosquito-Borne Diseases chikungunya prevention target dengue disease prevention target Zika virus infectious disease prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AEDES-BORNE DISEASES CHIKUNGUNYA DENGUE ZIKA

Contacts and locations

Locations

Universidad Autonoma de Yucatan

Mérida, Yucatán, 97203, Mexico

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