Flaviviridae infectious disease

This Phase 3 trial will test whether giving the dengue and chikungunya vaccines at the same time is as safe and effective as giving them separately. The study involves 900 healthy adults aged 18 to 59 who have never been exposed to either virus. Researchers will measure immune re…

This study tests whether the drug emetine can help people hospitalized with dengue fever. About 600 adults aged 18 to 65 will take either a low or high dose of emetine or a placebo pill for 7 days. Researchers will track if the drug reduces deaths or stops the disease from becomi…

This study compares two common antibiotic combinations—vancomycin with piperacillin/tazobactam versus vancomycin with meropenem—to see which is less harmful to the kidneys. About 852 hospitalized adults with serious infections will be randomly assigned to one of the two combos. T…

This large study tests several treatments in people hospitalized with moderate or severe dengue. The goal is to find safe, affordable drugs that prevent the disease from getting worse and help patients recover faster. Over 8,800 participants across multiple sites will be enrolled…

This study will collect blood samples from 200 people aged 12 and older who either have or do not have dengue. The goal is to use these samples to develop and improve diagnostic tests for dengue. Participants must have symptoms consistent with dengue and cannot have been vaccinat…

This study tests whether a 20-session exercise program can improve muscle strength, reduce fatigue, and help with balance in people who had dengue or chikungunya in the last five years. Fifty-four adults will do supervised aerobic, strength, and breathing exercises twice a week. …

This observational study will look at 10,000 adults in intensive care units (ICUs) around the world during a single 24-hour period. Researchers want to find out how common infections and antibiotic-resistant bacteria are, how they are treated, and how patients recover. No new tre…

This research project aims to understand why older adults get more infections and why those infections can be more serious. By following 23,000 people aged 60 and older, scientists will collect health data and samples like blood and stool to study how the immune system changes wi…

This observational study will enroll 190 hospitalized adults with dengue in Bangladesh to see if a 'leaky gut' — where bacteria and toxins escape the intestines into the blood — is linked to severe disease. Researchers will measure gut leakage markers in blood, perform abdominal …

This study looks at immune cells in the skin of 40 healthy adults who have never received a yellow fever vaccine. Researchers will take small skin samples and blood to measure baseline levels of memory T cells. The goal is to understand the skin's natural immune state before vacc…

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…

This study will follow 300 adults with severe infections in the ICU to see how levels of specialized pro-resolving mediators (SPMs)—natural molecules that help stop inflammation—change over time. Researchers will use blood samples already collected during routine care, so no extr…