New antibody shows promise against dengue in early trial
NCT ID NCT06799741
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tested a new drug called AV-1, which is a lab-made antibody, to see if it can prevent or treat dengue virus type 3 infection. Eighty-five healthy adults received either a low, medium, or high dose of AV-1 or a placebo, and were then exposed to a controlled dengue virus. Researchers measured safety, side effects, and how well the drug blocked the virus.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- AV-1 (a lab-made antibody given by IV)
- What this could lead to
- If it works, this could point toward a preventive treatment for dengue, a serious mosquito-borne disease.
- What could go wrong
- This is an early-phase trial with only 85 healthy adults, not patients. The results may not apply to real-world dengue infections, and the antibody may not work or could cause side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Center for Immunization Research (CIR) JHBSPH
Baltimore, Maryland, 21205, United States
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Center for Immunization Research Inpatient Unit
Baltimore, Maryland, 21224, United States
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UVM Larner College of Medicine Department of MMG
Burlington, Vermont, 05405, United States