Endogenous depression

This trial tests whether an internet-based form of cognitive behavior therapy (CBT) can reduce symptoms of common mental disorders like anxiety, depression, and stress-related conditions in adults seeking primary care. About 500 participants will be randomly assigned to either th…

This pilot study tests whether a portable, at-home brain stimulation device (tDCS) can help people with depression maintain the improvements they achieved during hospital treatment with esketamine, rTMS, or ECT. Thirty adults will use the device for 30 minutes a day, five days a …

This pilot study will test whether a mobile phone app can help reduce depression symptoms in African American adults. Eight participants will attend six weekly 90-minute classes through the app and complete surveys over four months. The goal is to see if this approach is effectiv…

This study tests an online wellness course that teaches diet, exercise, stress reduction, and self-care to people with rheumatoid arthritis, lupus, Sjogren's syndrome, and similar conditions. Researchers want to see if the program reduces fatigue and improves quality of life. Abo…

This study tests whether inhaling DMT, a psychedelic drug, can quickly reduce symptoms of major depression and suicidal thoughts. 140 adults with moderate-to-severe depression will receive either a high or low dose of DMT in two puffs. Those not improved after a week can get an e…

This study tests whether wearing a headset that delivers a flickering 60Hz white light for 30 minutes a day can help ease depression symptoms. Adults with major depressive disorder will use the device at home for three weeks. Researchers will measure how well people stick with th…

This study tests a telemedicine-delivered cognitive behavioral program (RxWell) to help adults with anxiety or depression use fewer opioids after knee or hip replacement. About 150 participants will be enrolled. The program aims to improve mood and reduce painkiller use by provid…

This study compares a standard mobile cognitive behavioral therapy (CBT) program to a personalized version that teaches skills faster. About 100 adults aged 18-25 with anxiety, depression, or bipolar disorder will use the Maya app for 20 minutes, twice a week, for six weeks. The …

This study is testing a mobile app called MAYA that teaches cognitive behavioral therapy (CBT) skills to help older adults manage anxiety and depression. About 60 participants aged 40 and older with an anxiety or depressive disorder will use the app for at least 20 minutes, twice…

This Phase 2 trial tests LV232, a new capsule for major depressive disorder, in 400 adults aged 18-65. Participants are randomly assigned to receive one of two doses of LV232, the active comparator escitalopram, or a placebo for 8 weeks. The main goal is to find the best dose and…

This study is testing whether psilocybin (the active ingredient in magic mushrooms) combined with therapy is safe and helpful for people with non-small cell lung cancer who also have major depression. Ten participants will receive psilocybin in a controlled setting along with cou…

This study tests whether a single 25 mg dose of psilocybin can relieve major depression in 100 adults with cancer, compared to a very low 1 mg dose. Participants must be 20–80 years old, have had depression for at least a month after their cancer diagnosis, and stop other antidep…

This study looks at whether a specific yoga practice can help improve memory, attention, and mental flexibility in people whose depression is in remission. Researchers will compare a group doing yoga plus their usual care to a group receiving usual care alone. The goal is to see …

This study tests a brief group therapy that teaches people to better understand their own and others' thoughts and feelings (called mentalization). One hundred adults with anxiety or depression will be randomly assigned to this new therapy or to standard group therapy. Researcher…

This early-stage study at Yale is testing whether a single 25 mg dose of psilocybin is safe and tolerable for people whose daily life is impaired by mood, anxiety, trauma, or addiction symptoms. Fifty participants will receive the drug openly (everyone knows they get it) and be f…

This study tests whether taking omega-3 (EPA) supplements for 12 weeks can reduce depressive symptoms in overweight or obese adults who have depression and low omega-3 levels. Half of the 50 participants will receive EPA, and half will receive a placebo. Researchers will also loo…

This study compares two non-invasive brain stimulation techniques for treating depression: right-sided 1-Hz rTMS and left-sided iTBS. Researchers want to see if the right-sided method works as well as the standard left-sided one. The trial will involve 350 adults with unipolar or…

This study tests whether enoxolone, a compound from licorice, can improve depression symptoms in 80 adults with unipolar depression. Researchers will measure biomarkers like hormone levels and blood pressure to see if they predict who responds better to enoxolone versus a placebo…

This study is for adults aged 22-65 with major depression that hasn't improved with other treatments. Researchers want to see if giving psilocybin (the active ingredient in magic mushrooms) followed by a quick, focused brain stimulation technique is safe and can help reduce depre…

This study tests a device that delivers mild electrical stimulation to the brain (tDCS) while people practice mindfulness, all done remotely via video calls. The goal is to see if this combination can reduce depression symptoms in 25 adults with major depressive disorder. Partici…

This study tests whether adding social cognitive training—like learning to understand another person's point of view—to standard cognitive behavioral therapy (CBT) helps teens with depression feel better. Researchers will compare two groups of 82 teens aged 13-17: one gets CBT pl…

This study at the National Institute of Mental Health screens up to 16,000 people with mood or anxiety disorders, as well as healthy volunteers, to see if they can join other research studies. Participants undergo evaluations like psychiatric interviews, brain scans, and lab test…

This study looks at how feeling lonely and being socially isolated affect the brain and daily life in people with serious mental illnesses like psychosis or schizophrenia. Researchers will use surveys, daily diaries, and brain scans to understand these connections. The goal is to…

This study investigates whether tiny particles called exosomes, released by brain cells and found in the blood, can serve as biomarkers for depression and suicide risk in adolescents. Researchers will analyze genetic material from these exosomes in 240 teenagers, including those …

This study will carefully examine the physical and mental health of 100 adults admitted to NHS mental health wards. Researchers will review medical notes, do physical exams, and use questionnaires to measure conditions like bipolar disorder, schizophrenia, depression, and persona…

This study investigates whether the quality of parent-adolescent communication at the start of psychiatric inpatient treatment predicts how much symptoms improve six months later. Researchers will track 60 adolescents hospitalized for depression, anxiety, or other mental disorder…

This study looks at how tiny changes in your RNA (a molecule that reads your DNA) might help predict whether depression treatments will work. Researchers will follow 120 adults with unipolar or bipolar depression to see if these RNA changes match up with improvements in mood. The…

This study tests whether a gentle brain stimulation technique called tDCS, done at home, can improve sleep quality in adults with moderate depression. Researchers will track sleep changes and see if better sleep leads to better mood. The study involves 35 participants and aims to…

This study follows 415 people with difficult-to-treat depression for 5 years after they joined an earlier genetics study. Researchers will review medical records and registry data to see how patients' depression changes over time, including suicide attempts and treatment response…

This study looks at why people with mood disorders may be at risk for suicide. Researchers will collect blood, urine, and survey answers from 300 participants to find patterns and build a model that predicts suicide risk. The goal is to better understand the factors involved so d…

People with serious mental illness often have undiagnosed physical conditions like heart disease, diabetes, and cancer. This study tests whether adding routine physical health checks to psychiatric care helps find and treat these hidden illnesses. About 2,800 adults in Denmark wi…

This study compares women with PMDD, major depressive disorder (MDD), and healthy controls to see how their brains, stress responses, and inflammation differ. Researchers will use brain scans, stress tasks, and blood/saliva tests in 75 naturally cycling women aged 18-40. The goal…

This study tests whether combining a one-time session of brain stimulation (rTMS or electrical scalp stimulation) with emotion regulation training helps people with mood, anxiety, or related disorders better control their emotions. 240 participants will learn either cognitive res…

This study observes 100 people with depression who are already receiving transcranial magnetic stimulation (TMS) therapy. Researchers use brain scans and symptom questionnaires to see how brain networks change during treatment and whether these changes can predict who gets better…

This study is looking at how a non-invasive brain stimulation treatment called TMS changes the brain in people with depression. 100 adults will receive 20 TMS sessions over four weeks and have MRI scans at several points. The goal is to find brain imaging markers that can predict…

This study tests whether a special eye-tracking device (Gaize) can identify changes in eye movement patterns caused by long-term use of psychiatric medications. Researchers will observe 50 adults with conditions like ADHD, depression, or anxiety who have been on medication for ov…

This study tests a web-based app called PST-Aid that helps clinicians guide patients through problem-solving therapy for depression. About 410 clinicians and their patients from community health centers will take part. The goal is to see if the app makes it easier for clinicians …