Central nervous system disorder
MONDO:0002602A disease involving the central nervous system.
Also known as: CNS disorder, central nervous disease, central nervous system disease, central nervous system disease or disorder, central nervous system disorder, disease of central nervous system, disease of the central nervous system, disease or disorder of central nervous system
20455 clinical trials for this condition and its sub-types, 119 tagged with Central nervous system disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Central nervous system disorder
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Brain disorder 137 trials · 16,709 incl. sub-types
71 sub-types
- Mental disorder 250 trials · 7,390 incl. sub-types Sub-types →
- Cerebrovascular disorder 108 trials · 3,292 incl. sub-types Sub-types →
- Basal ganglia disorder 9 trials · 1,322 incl. sub-types Sub-types →
- Brain neoplasm 247 trials · 1,080 incl. sub-types Sub-types →
- Multiple sclerosis 770 trials · 858 incl. sub-types Sub-types →
- Insomnia 823 trials · 827 incl. sub-types Sub-types →
- Cerebral cortex disorder 0 trials · 723 incl. sub-types Sub-types →
- Brain injury 220 trials · 693 incl. sub-types Sub-types →
- Epilepsy 461 trials · 645 incl. sub-types Sub-types →
- Migraine disorder 393 trials · 414 incl. sub-types Sub-types →
- Cerebellar disorder 9 trials · 271 incl. sub-types Sub-types →
- Visual pathway disorder 1 trial · 201 incl. sub-types Sub-types →
- Pituitary gland disorder 18 trials · 175 incl. sub-types Sub-types →
- Thalamic disorder 0 trials · 110 incl. sub-types Sub-types →
- Intracranial hypertension 51 trials · 97 incl. sub-types Sub-types →
- Encephalitis 26 trials · 96 incl. sub-types Sub-types →
- Hydrocephalus 52 trials · 79 incl. sub-types Sub-types →
- Cerebral degeneration 0 trials · 61 incl. sub-types Sub-types →
- Hepatic encephalopathy 45 trials Sub-types →
- Narcolepsy-cataplexy syndrome 42 trials · 44 incl. sub-types Sub-types →
- Cerebral lipidosis with dementia 0 trials · 38 incl. sub-types Sub-types →
- Intracranial hypotension 32 trials
- Cluster headache syndrome 26 trials Sub-types →
- Brain edema 23 trials
- Narcolepsy without cataplexy 22 trials
- Encephalomalacia 1 trial · 13 incl. sub-types Sub-types →
- Olfactory nerve disorder 8 trials · 12 incl. sub-types Sub-types →
- Prion disease 5 trials · 11 incl. sub-types Sub-types →
- Traumatic encephalopathy 11 trials
- Cerebral cortical dysplasia 2 trials · 7 incl. sub-types Sub-types →
- Progressive bulbar palsy 5 trials Sub-types →
- Akinetic mutism 3 trials
- Bilirubin encephalopathy 3 trials Sub-types →
- Central nervous system cyst 3 trials Sub-types →
- Encephaloclastic disorder 0 trials · 3 incl. sub-types Sub-types →
- Encephalopathy, acute, infection-induced 2 trials · 3 incl. sub-types Sub-types →
- Megalencephaly 3 trials Sub-types →
- Cerebral malaria 2 trials
- Leukoencephalopathy, megalencephalic 0 trials · 2 incl. sub-types Sub-types →
- Wernicke encephalopathy 1 trial
- Brain compression 1 trial
- Carbon monoxide-induced delayed encephalopathy 1 trial
- Cerebral sarcoidosis 1 trial
- Reye syndrome 0 trials
- XK aprosencephaly 0 trials
- Acute bilirubin encephalopathy 0 trials
- Aprosencephaly 0 trials
- Atelencephaly 0 trials
- Autoimmune encephalopathy with parasomnia and obstructive sleep apnea 0 trials
- Autosomal recessive frontotemporal pachygyria 0 trials
- Brain malformations with or without urinary tract defects 0 trials
- Bulbar polio 0 trials
- Central nervous system origin vertigo 0 trials
- Cerebritis 0 trials
- Chronic bilirubin encephalopathy 0 trials
- Colpocephaly 0 trials
- Complex cortical dysplasia with other brain malformations 0 trials Sub-types →
- Corpus callosum agenesis of blepharophimosis robin type 0 trials
- Corpus callosum dysgenesis X-linked recessive 0 trials
- Corpus callosum dysgenesis cleft spasm 0 trials
- Corpus callosum dysgenesis hypopituitarism 0 trials
- Diabetic encephalopathy 0 trials
- Disorder of optic chiasm 0 trials
- Encephalopathy due to mitochondrial and peroxisomal fission defect 0 trials Sub-types →
- Encephalopathy, acute transient 0 trials
- Encephalopathy, recurrent, of childhood 0 trials
- Glycine encephalopathy 0 trials Sub-types →
- Hypothalamic hamartomas with gelastic seizures 0 trials
- Meningoencephalocele 0 trials
- Midbrain disorder 0 trials
- Occipital pachygyria and polymicrogyria 0 trials
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Neurodegenerative disease 187 trials · 3,289 incl. sub-types
22 sub-types
- Tauopathy 24 trials · 1,193 incl. sub-types Sub-types →
- Demyelinating disease 27 trials · 938 incl. sub-types Sub-types →
- Inherited neurodegenerative disorder 11 trials · 808 incl. sub-types Sub-types →
- Motor neuron disorder 70 trials · 510 incl. sub-types Sub-types →
- Synucleinopathy 18 trials · 237 incl. sub-types Sub-types →
- Cerebellar degeneration 6 trials · 150 incl. sub-types Sub-types →
- Primary progressive aphasia 42 trials · 71 incl. sub-types Sub-types →
- Cerebral degeneration 0 trials · 61 incl. sub-types Sub-types →
- Neuroaxonal dystrophy 1 trial · 9 incl. sub-types Sub-types →
- Secondary Parkinson disease 9 trials Sub-types →
- Primary progressive apraxia of speech 2 trials
- Marchiafava-Bignami disease 1 trial
- Human prion disease 1 trial Sub-types →
- Brachial amyotrophic diplegia 0 trials
- Choroidal sclerosis 0 trials Sub-types →
- Eyelid degenerative disorder 0 trials
- Hypertrophic olivary degeneration 0 trials
- Infantile bilateral striatal necrosis 0 trials Sub-types →
- Olivopontocerebellar atrophy 0 trials
- Primary progressive freezing gait 0 trials
- Senile degeneration of brain 0 trials
- Superficial siderosis 0 trials
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Central nervous system neoplasm 51 trials · 1,986 incl. sub-types
10 sub-types
- Central nervous system cancer 131 trials · 1,706 incl. sub-types Sub-types →
- Brain neoplasm 247 trials · 1,080 incl. sub-types Sub-types →
- Tumor of meninges 1 trial · 123 incl. sub-types Sub-types →
- Central nervous system hematopoietic neoplasm 0 trials · 107 incl. sub-types Sub-types →
- Spinal cord neoplasm 36 trials · 77 incl. sub-types Sub-types →
- Autonomic nervous system neoplasm 0 trials · 60 incl. sub-types Sub-types →
- Central nervous system organ benign neoplasm 1 trial · 57 incl. sub-types Sub-types →
- Central nervous system germ cell tumor 6 trials · 9 incl. sub-types Sub-types →
- Epidural abscess 5 trials
- Optic nerve neoplasm 1 trial · 4 incl. sub-types Sub-types →
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Spinal cord disorder 47 trials · 1,255 incl. sub-types
10 sub-types
- Spinal cord injury 650 trials
- Anterior horn disorder 0 trials · 485 incl. sub-types Sub-types →
- Spinal cord neoplasm 36 trials · 77 incl. sub-types Sub-types →
- Spina bifida 44 trials · 59 incl. sub-types Sub-types →
- Myelitis 4 trials · 52 incl. sub-types Sub-types →
- Syringomyelia 6 trials Sub-types →
- Tethered spinal cord syndrome 6 trials
- Radiation myelitis 0 trials
- Segmental spinal dysgenesis 0 trials
- Vascular myelopathy 0 trials
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Autoimmune disorder of central nervous system 2 trials · 881 incl. sub-types
8 sub-types
- Multiple sclerosis 770 trials · 858 incl. sub-types Sub-types →
- Autoimmune encephalitis 32 trials · 33 incl. sub-types Sub-types →
- Central nervous system lupus 3 trials
- Autoimmune epilepsy 1 trial
- Miller Fisher syndrome 0 trials
- Autoimmune encephalopathy with parasomnia and obstructive sleep apnea 0 trials
- Autoimmune optic neuritis 0 trials
- Primary hypophysitis 0 trials Sub-types →
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Palsy 36 trials · 846 incl. sub-types
10 sub-types
- Cerebral palsy 443 trials · 499 incl. sub-types Sub-types →
- Hemiplegia 176 trials · 179 incl. sub-types Sub-types →
- Quadriplegia 73 trials
- Paraplegia 47 trials · 68 incl. sub-types Sub-types →
- Facial paralysis 19 trials · 34 incl. sub-types Sub-types →
- Respiratory paralysis 20 trials
- Erb palsy 11 trials
- Ophthalmoplegia 0 trials · 11 incl. sub-types Sub-types →
- Progressive bulbar palsy 5 trials Sub-types →
- Klumpke's paralysis 0 trials
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Encephalomyelitis 3 trials · 227 incl. sub-types
7 sub-types
- Encephalitis 26 trials · 96 incl. sub-types Sub-types →
- Meningitis 42 trials · 73 incl. sub-types Sub-types →
- Myelitis 4 trials · 52 incl. sub-types Sub-types →
- Optic neuritis 21 trials · 25 incl. sub-types Sub-types →
- Hypophysitis 2 trials Sub-types →
- Venezuelan equine encephalitis 1 trial
- Cerebritis 0 trials
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Autonomic nervous system disorder 59 trials · 209 incl. sub-types
13 sub-types
- Dysautonomia 16 trials · 64 incl. sub-types Sub-types →
- Autonomic nervous system neoplasm 0 trials · 60 incl. sub-types Sub-types →
- Sympathetic nervous system disorder 8 trials · 28 incl. sub-types Sub-types →
- Pure autonomic failure 18 trials
- Autonomic dysreflexia 11 trials
- Autonomic neuropathy 7 trials · 10 incl. sub-types Sub-types →
- Central hypoventilation syndrome, congenital, 1, with or without Hirschsprung disease 5 trials
- Baroreflex failure 1 trial
- Frey syndrome 0 trials
- Chronic hiccup 0 trials
- Harlequin syndrome 0 trials
- Idiopathic peripheral autonomic neuropathy 0 trials
- Parasympathetic nervous system disorder 0 trials Sub-types →
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Central nervous system infectious disorder 10 trials · 163 incl. sub-types
12 sub-types
- Viral infection of central nervous system 3 trials · 58 incl. sub-types Sub-types →
- Infectious encephalitis 3 trials · 50 incl. sub-types Sub-types →
- Infectious meningitis 3 trials · 49 incl. sub-types Sub-types →
- Prion disease 5 trials · 11 incl. sub-types Sub-types →
- Central nervous system tuberculosis 1 trial · 7 incl. sub-types Sub-types →
- Epidural abscess 5 trials
- Intracranial abscess 3 trials
- Cerebral malaria 2 trials
- Congenital toxoplasmosis 2 trials
- Human prion disease 1 trial Sub-types →
- Subdural empyema 1 trial
- Neuroschistosomiasis 0 trials
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Optic nerve disorder 23 trials · 96 incl. sub-types
8 sub-types
- Optic atrophy 4 trials · 26 incl. sub-types Sub-types →
- Optic neuritis 21 trials · 25 incl. sub-types Sub-types →
- Low tension glaucoma 21 trials
- Anterior ischemic optic neuropathy 9 trials · 11 incl. sub-types Sub-types →
- Optic nerve neoplasm 1 trial · 4 incl. sub-types Sub-types →
- Optic disk drusen 1 trial
- Extensive peripapillary myelinated nerve fibers 0 trials
- Isolated optic nerve aplasia 0 trials
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Tinnitus 91 trials
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Central nervous system vasculitis 3 trials · 55 incl. sub-types
5 sub-types
- Temporal arteritis 52 trials Sub-types →
- Primary central nervous system vasculitis 2 trials Sub-types →
- Benign angiitis of the central nervous system 0 trials
- Central nervous system AIDS arteritis 0 trials
- Cerebral arteritis 0 trials
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Trigeminal neuralgia 37 trials
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Cerebrospinal fluid leak 16 trials · 17 incl. sub-types
1 sub-type
- Cerebrospinal fluid rhinorrhea 2 trials
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High pressure neurological syndrome 0 trials · 5 incl. sub-types
1 sub-type
- Decompression sickness 5 trials
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SPAST-related motor disorder 0 trials · 2 incl. sub-types
1 sub-type
- Hereditary spastic paraplegia 4 2 trials
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1 sub-type
- NDE1-related microhydranencephaly 0 trials
Most studied deeper sub-types
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New drug aims to slow Alzheimer's in early stages
Disease control Stopped earlyThis study tests an experimental drug called GSK4527226 in 367 people with early Alzheimer's (mild memory problems or mild dementia). Participants receive either a low dose, high dose, or placebo through an IV. The goal is to see if the drug can slow down declines in memory and d…
Phase 2 • Sponsor: GlaxoSmithKline • Aim: Disease control
Last updated Sep 19, 2026 00:00 UTC
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Alzheimer's drug ALZ-801 tested Long-Term in High-Risk group
Disease control Stopped earlyThis study looked at the long-term safety and effects of ALZ-801, a tablet taken twice daily, in 163 people with early Alzheimer's disease who have the APOE4/4 gene. Participants had already completed a previous phase 3 study. The goal was to see if the drug could slow cognitive …
Phase 3 • Sponsor: Alzheon Inc. • Aim: Disease control
Last updated Jun 27, 2026 14:02 UTC
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Alzheimer's drug trial halted early: what happened?
Disease control Stopped earlyThis early-stage study tested a new drug, ADEL-Y01, in healthy volunteers and people with mild Alzheimer's or mild cognitive impairment. The goal was to check safety and how the drug moves through the body. The trial was stopped early, so results are limited.
Phase 1 • Sponsor: Alzheimer's Disease Expert Lab (ADEL), Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:26 UTC
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Alzheimer's drug extension trial halted early — what we know
Disease control Stopped earlyThis study gave Alzheimer's patients who had already completed earlier XPro1595 trials an extra 55 to 74 weeks of the drug to check long-term safety and effects on memory and brain health. Only 11 people took part, and the trial was terminated early, so the findings are limited. …
Phase 2 • Sponsor: Inmune Bio, Inc. • Aim: Disease control
Last updated Jun 27, 2026 09:08 UTC