Bone remodeling disease

This trial tests whether postural correction exercises can improve pelvic floor muscle function in postmenopausal women aged 55 to 65 who have osteoporosis and mild to moderate pelvic floor dysfunction. Participants receive estrogen replacement therapy and general posture advice,…

This phase II trial tests an investigational drug called TST002 in postmenopausal women aged 45 to 80 who have osteoporosis or low bone mass. The study compares three different doses of TST002 against a placebo and an existing osteoporosis drug, denosumab. The main goal is to see…

This study will test whether a 12-week group exercise program is safe and practical for people with osteoporosis who have recently had a fracture. One hundred participants will attend twice-weekly classes and undergo bone scans and interviews. The goal is to see if this type of p…

This trial tests whether a short course of romosozumab followed by denosumab can increase bone density more than the standard treatment zoledronic acid in postmenopausal women with osteoporosis and high fracture risk. Participants receive either the romosozumab-denosumab sequence…

This trial tests whether a calcium-rich food chew, made from milk-derived minerals, is easier for women to take daily than a standard calcium carbonate pill. Women aged 40 to 90 at increased risk for osteoporosis will be randomly assigned to one of the two forms for four weeks. T…

This study follows people with bone loss caused by long-term steroid use to compare two treatment approaches. One group received romosozumab for the first year and then switched to denosumab, while the other group took denosumab throughout. After six years, researchers will measu…

This trial tests whether testosterone therapy can help men with spinal cord injury who have low testosterone and difficulty walking. The goal is to see if it increases muscle and bone in the legs, reduces body fat, and improves strength. Some participants also receive finasteride…

This trial investigates how the drug zoledronic acid is processed in the body of people with chronic kidney disease who are on dialysis and also have osteoporosis. It aims to find the best dose—either 2.5 mg or 5 mg—given as a single intravenous injection during a dialysis sessio…

This trial tests whether adding high-intensity laser therapy (HILT) to a physiotherapy programme can improve bone health in postmenopausal women with osteopenia or osteoporosis. Forty women will receive either real or sham laser sessions on their lower back, three times a week fo…

This study compares three ways to rebuild bone in the back of the lower jaw before placing dental implants. Seventy-eight adults will receive a graft made from their own bone, cow bone, or donated human bone. The main goal is to see which method adds the most width to the jawbone…

This study tests whether a newer type of dialysis filter (medium cut-off membrane) can better manage bone and mineral problems common in people with end-stage kidney disease. Thirty adults on maintenance dialysis will try both the new and standard filters for three months each. R…

This study will compare two materials used for the caps that attach dentures to dental implants: acetal resin and nylon. The goal is to see which one causes less bone loss around the implants and keeps gums healthier. Twenty-two people with no teeth in their lower jaw will be enr…

This study tests whether a low dose of colchicine, a common anti-inflammatory drug, can slow down blood vessel hardening and bone problems in people with stage 3 chronic kidney disease. About 60 adults will take colchicine or receive usual care for 12 months. The goal is to see i…

This study will review medical records and call patients who received AGN1 LOEP, a device injected into the hip bone to treat osteoporosis. Researchers want to see how many patients later had hip fractures and whether any side effects occurred. The goal is to understand how well …

This study tests whether a new once-daily version of a probiotic food (SBD111) works as well as the current twice-daily version in healthy adults aged 35 and older. The goal is to see if the new formula leads to similar levels of helpful gut microbes. Participants take capsules f…

This trial is testing whether custom-made 3D-printed titanium implants are safe and work well for people with bone defects. Ten patients will receive an implant designed from their own CT or MRI scans. The study will track complications, implant stability, and bone healing over t…

This small study tests a dental implant technique that leaves a piece of the natural tooth root (socket shield) and uses a mix of growth factors and bone graft material to support the implant. Seven adults needing a front tooth implant will be followed for 6 months to check bone …

This study tests a dental implant technique that keeps a small piece of the natural tooth root to help preserve bone. It combines this with a special blood-derived growth factor and a bone graft material. Seven adults needing a front tooth implant will be followed for 6 months to…

This study compares a high-intensity loading dose of vitamin D2 to standard weekly dosing in 52 patients with newly diagnosed aggressive non-Hodgkin lymphoma who are also receiving standard chemotherapy. The goal is to see if the high-dose approach normalizes vitamin D levels fas…

This study tests whether adding denosumab to standard care can strengthen bones and prevent fractures in 358 adults with type 2 diabetes who are at high risk for breaks. Participants will receive the drug or a placebo, and researchers will measure changes in bone density and frac…

This study looks at whether a short, home-based exercise program can improve bone strength in postmenopausal women with low bone density. It will compare women who are already taking bone-strengthening medication with those who are not. The goal is to see if exercise adds extra b…

This study looks at whether semaglutide (a diabetes drug that lowers blood sugar and helps with weight loss) affects bone density and fracture risk in people with type 2 diabetes. About 150 adults aged 50–75 will get either semaglutide plus metformin or metformin alone for 12 mon…

This study explores whether a single MRI fat-fraction (MRI-FF) scan can accurately diagnose osteoporosis and sarcopenia (muscle loss) in people with chronic kidney disease (CKD). Researchers will compare MRI-FF results with standard DXA scans in 868 participants—half with CKD and…

This study will check whether two easy-to-use questionnaires (OST and ORAI) can accurately predict osteoporosis in 1,500 postmenopausal Turkish women aged 50-75. Researchers will compare the questionnaire results with the gold-standard DEXA bone density scan. If the tools work we…

This trial tests whether applying a 5% lidocaine plaster daily for two months can prevent chronic nerve pain after an osteoporotic vertebral fracture. Participants aged 50 and older with a recent fracture and moderate pain are randomly assigned to receive the plaster plus standar…

This study tests whether a program of exercise, lifestyle changes, and a smart chatbot can prevent osteoporosis and sarcopenia in 8,336 adults aged 40-60. Participants are split into two groups: one gets active support with structured workouts and reminders, the other gets basic …

This trial tests whether a daily oral cannabis extract with a 5:1 CBD-to-THC ratio can reduce chronic pain in women aged 45 to 80 who haven't found relief from standard treatments. Participants will receive either the cannabis extract or a placebo in a crossover design, allowing …

This trial tests whether a structured 12-week physiotherapy exercise program can improve balance, posture, and reduce fall risk in people with osteoporosis. Participants, aged 50 and older, will be randomly assigned to either the exercise program or a control group. The program f…

This study compares two surgical methods for treating unstable pelvic fractures in people aged 60 and older with osteoporosis. Half of the 88 participants will receive robot-assisted minimally invasive screw placement, while the other half will have conventional open surgery. The…

This study looks at a surgery called calcaneal osteotomy for adults with severe plantar fasciosis that hasn't improved with other treatments. The surgery aims to reduce tension on the plantar fascia without cutting it. Researchers will measure pain and foot function in 11 partici…

This study looks at whether adding bone graft up to a person's natural bone line (IPD) or slightly beyond it leads to better long-term stability after dental implant surgery. Twenty-eight adults needing a tooth replacement in the upper jaw will receive an implant and bone graft, …

This study looks at whether women with lipedema, a condition that causes abnormal fat buildup in the legs and arms, are more likely to have osteoporosis, a condition that weakens bones. Researchers will measure bone density in the spine and hip of 120 postmenopausal women with li…

This study looks at saliva from people with osteoporosis to measure certain immune markers and an enzyme called MMP-8. Researchers also check participants' dental cavities. The goal is to better understand how osteoporosis might affect oral health. No treatments are given—only sa…

This study is developing a way to predict who might develop a serious jaw bone condition called medication-related osteonecrosis of the jaw (MRONJ) after dental procedures. Researchers are following adults who have taken bone-strengthening drugs like bisphosphonates or denosumab …

This study looks at how different types of dialysis affect heart health, bone metabolism, inflammation, and quality of life in people with end-stage kidney disease. Researchers will compare patients on hemodialysis, continuous ambulatory peritoneal dialysis, and automated periton…

This study will take 3D scans of the inside of the mouth from 240 people with rare bone or cartilage diseases and from healthy volunteers. Researchers will use shape analysis and artificial intelligence to see if these scans can help tell different diseases apart. The goal is to …

This observational study will check vitamin C levels in 40 people with osteoporosis, comparing those who have had a spine fracture to those who haven't. The goal is to see if lower vitamin C is more common in the fracture group. No treatment is given; the study simply measures an…

This study looks at whether Guanxinning tablets can help repair tiny blood vessels in the heart after a heart attack. About 70 people who have had a severe heart attack will take the tablets or a placebo for 6 months. The main goal is to see if the tablets reduce bleeding in the …

This study is a registry that will collect health information from up to 5,000 women experiencing perimenopause, menopause, or premature ovarian insufficiency. Researchers will gather data from medical records and ongoing visits to a specialized clinic, tracking symptoms, treatme…

This study compares two ways to prepare the jawbone for dental implants in people with low bone density. One method uses Densah burs to compact bone, while the other removes bone with standard drilling. The goal is to see which gives better implant stability right after placement…

This study uses blood samples from 20 dental patients to see how well a bone-growth protein (rhBMP-2) sticks to a natural blood-derived scaffold (E-PRF) and releases over time. Researchers compare this to the standard sponge carrier and combinations. The goal is to find a better …

This study will measure two proteins (myostatin and irisin) in the blood of 60 postmenopausal women aged 50-65. Researchers will group participants by bone density (normal, low, or very low) and test their muscle strength. The goal is to see if these proteins are linked to bone a…

This study will review medical records of 8,000 adults with osteoporosis who have had a fragility fracture. Researchers want to measure how long it takes for patients to start medication that prevents future fractures. They also want to see if longer delays lead to more fractures…

This study is testing an AI voice assistant named Dora that makes automated phone calls to patients who have had a bone fracture. The goal is to see if Dora can safely and accurately collect information about risk factors and medication side effects, compared to a regular call fr…

This study aims to create an early warning system for osteoporotic vertebral compression fractures (OVCF) by combining Traditional Chinese Medicine (TCM) patterns with standard risk factors like bone density. Researchers will follow 200 adults aged 50-79 with new fractures or low…

This study looks at whether a simple, non-invasive skin test can help predict how well osteoporosis medications work. Researchers will measure substances called AGEs in the skin of 240 postmenopausal women starting treatment. The goal is to see if higher AGE levels are linked to …

This study will follow 1000 adults with advanced chronic kidney disease (stage 4-5) to learn why they face higher risks of bone fractures and heart disease. Researchers will track bone turnover markers, calcium and phosphate levels, and kidney function over time. No new treatment…

This study will check how often bone loss happens around PEEK (a type of plastic) suture anchors used in hand and wrist surgeries, compared to metal or dissolving anchors. Researchers will review X-rays from 180 patients who had surgery in the past 10 years. They want to see if P…

This study looks at how the size of the connector piece (abutment) on a dental implant affects the bone around it. Researchers will place implants in 40 adults with a missing back tooth and use either a narrow or regular abutment. Over 24 months, they will measure bone changes on…