Bone remodeling disease

This study will compare two materials used for the caps that attach dentures to dental implants: acetal resin and nylon. The goal is to see which one causes less bone loss around the implants and keeps gums healthier. Twenty-two people with no teeth in their lower jaw will be enr…

This study tests whether a low dose of colchicine, a common anti-inflammatory drug, can slow down blood vessel hardening and bone problems in people with stage 3 chronic kidney disease. About 60 adults will take colchicine or receive usual care for 12 months. The goal is to see i…

This study will review medical records and call patients who received AGN1 LOEP, a device injected into the hip bone to treat osteoporosis. Researchers want to see how many patients later had hip fractures and whether any side effects occurred. The goal is to understand how well …

This study will test whether a 12-week group exercise program is safe and practical for people with osteoporosis who have recently had a fracture. One hundred participants will attend twice-weekly classes and undergo bone scans and interviews. The goal is to see if this type of p…

This study looks at whether a drug called abaloparatide can improve bone quality in people with osteoporosis who need spine surgery. About 60 participants will take the drug for 3-6 months before and after surgery. The goal is to see if it reduces complications like broken hardwa…

This study tests whether a new once-daily version of a probiotic food (SBD111) works as well as the current twice-daily version in healthy adults aged 35 and older. The goal is to see if the new formula leads to similar levels of helpful gut microbes. Participants take capsules f…

This trial is testing whether custom-made 3D-printed titanium implants are safe and work well for people with bone defects. Ten patients will receive an implant designed from their own CT or MRI scans. The study will track complications, implant stability, and bone healing over t…

This small study tests a dental implant technique that leaves a piece of the natural tooth root (socket shield) and uses a mix of growth factors and bone graft material to support the implant. Seven adults needing a front tooth implant will be followed for 6 months to check bone …

This study tests a dental implant technique that keeps a small piece of the natural tooth root to help preserve bone. It combines this with a special blood-derived growth factor and a bone graft material. Seven adults needing a front tooth implant will be followed for 6 months to…

This study compares three ways to rebuild bone in the back of the lower jaw before placing dental implants. Seventy-eight adults will receive a graft made from their own bone, cow bone, or donated human bone. The main goal is to see which method adds the most width to the jawbone…

This study compares two bone-strengthening drugs, ibandronate and zoledronic acid, given after stopping denosumab in postmenopausal women with osteoporosis. The goal is to see which drug better maintains bone density and prevents fractures. About 52 women aged 50-85 who took deno…

This early-stage trial is testing whether taking blackcurrant extract capsules can slow bone loss in women who have gone through menopause. The study will measure changes in bone density and gut bacteria over 12 months in 159 women aged 45-70. The goal is to see if the berries wo…

This study compares a high-intensity loading dose of vitamin D2 to standard weekly dosing in 52 patients with newly diagnosed aggressive non-Hodgkin lymphoma who are also receiving standard chemotherapy. The goal is to see if the high-dose approach normalizes vitamin D levels fas…

This study tests whether adding denosumab to standard care can strengthen bones and prevent fractures in 358 adults with type 2 diabetes who are at high risk for breaks. Participants will receive the drug or a placebo, and researchers will measure changes in bone density and frac…

This study looks at whether a short, home-based exercise program can improve bone strength in postmenopausal women with low bone density. It will compare women who are already taking bone-strengthening medication with those who are not. The goal is to see if exercise adds extra b…

This study looks at whether semaglutide (a diabetes drug that lowers blood sugar and helps with weight loss) affects bone density and fracture risk in people with type 2 diabetes. About 150 adults aged 50–75 will get either semaglutide plus metformin or metformin alone for 12 mon…

This study explores whether a single MRI fat-fraction (MRI-FF) scan can accurately diagnose osteoporosis and sarcopenia (muscle loss) in people with chronic kidney disease (CKD). Researchers will compare MRI-FF results with standard DXA scans in 868 participants—half with CKD and…

This study will check whether two easy-to-use questionnaires (OST and ORAI) can accurately predict osteoporosis in 1,500 postmenopausal Turkish women aged 50-75. Researchers will compare the questionnaire results with the gold-standard DEXA bone density scan. If the tools work we…

This study tests whether a program of exercise, lifestyle changes, and a smart chatbot can prevent osteoporosis and sarcopenia in 8,336 adults aged 40-60. Participants are split into two groups: one gets active support with structured workouts and reminders, the other gets basic …

This study tests whether a new medicine called Fexuprazan (Fexuclue) can prevent stomach ulcers caused by NSAID painkillers like ibuprofen. About 360 adults with joint or muscle pain who need daily NSAIDs will take either Fexuprazan or an older drug (Lansoprazole) for 24 weeks. T…

This study compares two surgical methods for treating unstable pelvic fractures in people aged 60 and older with osteoporosis. Half of the 88 participants will receive robot-assisted minimally invasive screw placement, while the other half will have conventional open surgery. The…

This study tests whether low-dose radiation therapy can ease pain and improve daily life for people with heel spurs and plantar fasciitis. About 35 adults who have had pain for at least 3 months will receive the treatment. Researchers will measure pain, function, and quality of l…

This study looks at a surgery called calcaneal osteotomy for adults with severe plantar fasciosis that hasn't improved with other treatments. The surgery aims to reduce tension on the plantar fascia without cutting it. Researchers will measure pain and foot function in 11 partici…

This early-phase trial will test four orthobiologic treatments—PRP, bone marrow concentrate, hyaluronic acid, and nanofat—in 300 adults with various muscle, joint, tendon, or bone conditions. The goal is to see if these natural substances can reduce pain and improve joint functio…

This study looks at whether a mobile app can help people with common pains (neck, shoulder, back, or knee) do their prescribed home exercises more regularly. About 30 adults will be split into two groups: one using the app and one doing traditional exercises. The goal is to see i…

This study tests whether balance training done at home via video calls works as well as in-person sessions for postmenopausal women with osteoporosis. Sixty women aged 50-70 with low bone density and balance issues will be randomly assigned to either remote or traditional trainin…

This study will take 3D scans of the inside of the mouth from 240 people with rare bone or cartilage diseases and from healthy volunteers. Researchers will use shape analysis and artificial intelligence to see if these scans can help tell different diseases apart. The goal is to …

This observational study will check vitamin C levels in 40 people with osteoporosis, comparing those who have had a spine fracture to those who haven't. The goal is to see if lower vitamin C is more common in the fracture group. No treatment is given; the study simply measures an…

This study aims to translate and adapt a widely used questionnaire for musculoskeletal problems into Urdu. Researchers will enroll 110 Urdu-speaking adults, including patients with muscle or joint issues and healthy volunteers. The goal is to create a validated tool to measure sy…

This study looks at whether Guanxinning tablets can help repair tiny blood vessels in the heart after a heart attack. About 70 people who have had a severe heart attack will take the tablets or a placebo for 6 months. The main goal is to see if the tablets reduce bleeding in the …

This study is a registry that will collect health information from up to 5,000 women experiencing perimenopause, menopause, or premature ovarian insufficiency. Researchers will gather data from medical records and ongoing visits to a specialized clinic, tracking symptoms, treatme…

This study will follow 100 adults with X-linked hypophosphatemia (XLH) who are already taking burosumab. Researchers want to see how phosphate levels change over time and how they relate to bone health and overall disease burden. The goal is to better understand the condition and…

This study looks at how patients feel when reading their own medical notes. Some will read the original doctor's note, others will read a simpler version written by artificial intelligence. Researchers want to see if the AI summary changes how much patients trust their doctor or …

This study compares two ways to prepare the jawbone for dental implants in people with low bone density. One method uses Densah burs to compact bone, while the other removes bone with standard drilling. The goal is to see which gives better implant stability right after placement…

This study looks at whether adding bone graft up to a person's natural bone line (IPD) or slightly beyond it leads to better long-term stability after dental implant surgery. Twenty-eight adults needing a tooth replacement in the upper jaw will receive an implant and bone graft, …

This study uses blood samples from 20 dental patients to see how well a bone-growth protein (rhBMP-2) sticks to a natural blood-derived scaffold (E-PRF) and releases over time. Researchers compare this to the standard sponge carrier and combinations. The goal is to find a better …

This study will measure two proteins (myostatin and irisin) in the blood of 60 postmenopausal women aged 50-65. Researchers will group participants by bone density (normal, low, or very low) and test their muscle strength. The goal is to see if these proteins are linked to bone a…

This study will review medical records of 8,000 adults with osteoporosis who have had a fragility fracture. Researchers want to measure how long it takes for patients to start medication that prevents future fractures. They also want to see if longer delays lead to more fractures…

This study aims to see if a structured education program based on the Health Belief Model can improve osteoporosis awareness and health beliefs in women aged 45 and older who have at least one risk factor for the disease. About 74 women will be randomly assigned to either receive…

This study aims to understand why people with fibrous dysplasia of bone or McCune-Albright syndrome experience chronic pain. Researchers will compare pain responses in 40 adults (20 patients and 20 healthy volunteers) using heat and cold tests. The goal is to see if the nervous s…

This study looks at patients who develop a condition called MRONJ (bone death in the jaw) after taking osteoporosis medications. When this happens around a dental implant, doctors disagree on whether to remove the implant or try to save it. The study will compare healing and bone…

This study is testing an AI voice assistant named Dora that makes automated phone calls to patients who have had a bone fracture. The goal is to see if Dora can safely and accurately collect information about risk factors and medication side effects, compared to a regular call fr…

This study tests a decision support system called SmaRTWork to help people on sick leave due to muscle or back pain return to work. About 298 adults in Norway will either use the system or receive usual care. The main goal is to see if the tool helps them return to work sustainab…

This study aims to create an early warning system for osteoporotic vertebral compression fractures (OVCF) by combining Traditional Chinese Medicine (TCM) patterns with standard risk factors like bone density. Researchers will follow 200 adults aged 50-79 with new fractures or low…

This study looks at whether a simple, non-invasive skin test can help predict how well osteoporosis medications work. Researchers will measure substances called AGEs in the skin of 240 postmenopausal women starting treatment. The goal is to see if higher AGE levels are linked to …

This study will follow 1000 adults with advanced chronic kidney disease (stage 4-5) to learn why they face higher risks of bone fractures and heart disease. Researchers will track bone turnover markers, calcium and phosphate levels, and kidney function over time. No new treatment…

This study will check how often bone loss happens around PEEK (a type of plastic) suture anchors used in hand and wrist surgeries, compared to metal or dissolving anchors. Researchers will review X-rays from 180 patients who had surgery in the past 10 years. They want to see if P…

This study looks at how the size of the connector piece (abutment) on a dental implant affects the bone around it. Researchers will place implants in 40 adults with a missing back tooth and use either a narrow or regular abutment. Over 24 months, they will measure bone changes on…