University Hospital, Basel, Switzerland

This study looks at whether a low dose of the steroid prednisolone can control liver inflammation (hepatitis) that sometimes happens as a side effect of cancer immunotherapy. About 63 cancer patients who develop moderate to severe liver inflammation will receive a low steroid dos…

This study is for people with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS) who have received a stem cell transplant from a half-matched donor. After the transplant, patients will get extra immune cells called natural killer (NK) cells from the same donor to hel…

This study looks at how two different dopamine agonist treatments affect blood sugar levels in people with prolactinoma, a type of pituitary tumor. About 60 adults who have not yet been treated will be randomly assigned to one of two treatment strategies. The main goal is to see …

This study tests a drug called nintedanib in 20 people who developed a serious lung condition (bronchiolitis obliterans syndrome) after a stem cell transplant. The drug is added to their regular immune-suppressing medicines for 12 months. The main goal is to see if the drug is sa…

This study tests a new treatment for patellofemoral osteoarthritis (knee arthritis) using a graft made from the patient's own nasal cartilage cells. About 150 adults aged 18-70 with knee arthritis will receive either this experimental implant or standard care (a cartilage repair …

This study tests whether adding the antibiotic linezolid to standard treatment helps people with serious staph infections in the blood. About 606 hospitalized adults will be randomly assigned to receive either standard antibiotics alone or standard antibiotics plus linezolid. The…

This study tests whether empagliflozin, a diabetes drug, can safely raise low sodium levels in patients with certain conditions like liver or kidney failure. About 172 adults with chronic low sodium will receive either the drug or a placebo for a short period. The goal is to see …

This study looks at whether slowly increasing the dose of the sleep medicine propofol based on each patient's needs can keep blood pressure more stable compared to a standard starting dose. It involves 320 adults aged 55 and older having planned non-cardiac surgery. The goal is t…

This study is testing whether a nasal spray containing oxytocin can help reduce anxiety and improve how people with central diabetes insipidus recognize emotions in others. About 112 adults with the condition and high anxiety levels will receive either oxytocin or a placebo spray…

This study aims to find out if the antidepressant effect of DMT is due to the psychedelic experience or a direct biological action. 112 adults with moderate-to-severe depression will receive DMT or a placebo, with some receiving a sedative to block the psychedelic effects. Resear…

This study tests whether using a smaller chest drain (16F) instead of the usual larger one (24F) can reduce pain after minimally invasive lung surgery. About 124 adults having lung cancer surgery will be randomly assigned to one of the two drain sizes. The main goal is to measure…

This study looks at whether MDMA (the active ingredient in ecstasy) can reduce pain. Twenty healthy adults will receive either MDMA or a placebo, while mild pain is created using small electrical pulses under the skin. Researchers will compare how MDMA affects the pain experience…

This study looks at whether a special retreat program called 'Via Shalva' is helpful and practical for people who have finished treatment for breast or gynecologic cancer. About 30 survivors will take part to see if the retreat improves their quality of life, stress, and overall …

This study looks at whether it is safe to temporarily stop taking beta-blockers (a heart medication) before a procedure called transcatheter aortic valve replacement (TAVR) for people with severe aortic stenosis. About 498 adults who are scheduled for TAVR and have been on beta-b…

This study follows 1000 men with enlarged prostate symptoms who receive Rezum water vapor therapy. The goal is to see how well the treatment relieves urinary symptoms and improves quality of life over 5 years. Participants are real-life patients treated at multiple centers, and t…

This study tests a peer-led program called PEGISUS to see if it can reduce substance use and promote fair gender attitudes among young people in vocational training in Zambia, Zimbabwe, and South Africa. About 264 participants aged 16-24 who use alcohol or drugs at least weekly w…

This study tracks quality of life and satisfaction in 1000 adults who had any type of breast surgery at University Hospital Basel. Researchers will use surveys to measure how patients feel after surgery. The goal is to better understand the real-world impact of breast surgery on …

This study looks at how different breathing pressures and lying face-down (prone position) change blood flow in the veins of healthy adults. Researchers will use ultrasound to measure vein congestion. The goal is to better understand these effects, not to treat any disease. About…

This study looks at how the metabolism (energy use) of cancer cells and immune cells in the bone marrow affects treatment success in blood cancers like leukemia and lymphoma. Researchers will collect samples from 350 adults to measure metabolites, lipids, and gene activity. The g…

This study is building a new tool to measure pain during cesarean delivery while the mother is awake. Researchers will combine expert opinions and interviews with 15 women who recently had a C-section to make sure the tool reflects what patients actually feel. The goal is to impr…

This study looks at whether taking 200mg of caffeine (about two cups of coffee) changes how active your brown adipose tissue (brown fat) is when you're mildly cold. Brown fat helps burn calories to generate heat. Researchers will scan 12 healthy adults with a PET-CT after they ta…

This study looks at whether a tool called the International Early Warning Score can help doctors predict which emergency room patients are at risk of dying within 30 days. Over 6,400 adults visiting the emergency department will be observed. The goal is to improve how quickly and…

This study follows nearly 20,000 patients who had major non-cardiac surgery to understand how often heart injury occurs around the time of surgery. Researchers will track deaths and major heart problems for one year after surgery. The goal is to learn who is at risk and how to be…

This study is for 100 adults with multiple sclerosis (MS) in Switzerland. Researchers want to find new ways to track the disease using medical images, lab tests, and smartphone data. The goal is to better understand how MS changes over time and help doctors make treatment decisio…

This study gives healthy adults a single intravenous dose of 5-MeO-DMT (a fast-acting psychedelic) or a placebo to measure its short-term effects on mood, heart rate, and blood levels. Participants are randomly assigned and don't know which they receive. The goal is to understand…

This pilot study aims to see if a new MRI method called AMIRA can better detect spinal cord lesions in people with multiple sclerosis (MS). Ten participants will undergo both standard and new MRI scans to compare how many lesions are found and how well doctors agree on the result…

This study looks at whether fluid buildup in veins (congestion) affects blood flow in the smallest blood vessels after planned heart surgery. Researchers will monitor 40 adults in the ICU using ultrasound and other tools. The goal is to better understand these connections, not to…

This study is for 500 adults having elective heart surgery with a heart-lung machine. Researchers will monitor each patient's personal blood pressure limits using special brain sensors. The goal is to see if keeping blood pressure within those limits reduces the risk of brain pro…

This study looks at whether trained community health workers can effectively screen and manage chronic diseases like high blood pressure and diabetes in rural Lesotho. About 17,500 adults will take part, with health workers using simple tools and eHealth apps to monitor and refer…

This study explores whether taking oral estradiol can trigger the release of oxytocin, a key hormone. Researchers aim to develop a safe diagnostic test for oxytocin deficiency in people with AVP deficiency (diabetes insipidus). The study involves 28 healthy adults and patients, m…

This study uses whole genome sequencing to track how ESBL-producing bacteria (a type of drug-resistant germ) spread among hospital patients and staff. Researchers will analyze samples from 2,000 people to find out whether infections come from other patients, the environment, or e…

This worldwide study looks at a rare but serious complication—a torn blood vessel—that can happen during a stroke treatment called thrombectomy. Researchers will study 1000 patients to find out what makes this tear more likely and how doctors can best manage it. The goal is to ma…

This study tests whether an artificial intelligence (AI) system can measure hydration status using ultrasound images of a large vein in the belly, compared to experienced and beginner human operators. Fifty healthy adults will have their vein scanned before and after a fluid chal…