Surgery vs. standard care: can microsurgery ease lymphedema after breast cancer?
NCT ID NCT05890677
First seen Nov 15, 2025 · Last updated Jun 20, 2026 · Updated 31 times
Summary
This trial compares two microsurgical techniques (LVA and VLNT) against standard conservative therapy for chronic lymphedema in breast cancer survivors. Researchers want to see if surgery leads to better quality of life one year after treatment. The study plans to enroll 280 adults with persistent arm swelling.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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BG Klinik Frankfurt am Main
RECRUITINGFrankfurt, 60389, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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BG Klinik Ludwigshafen
RECRUITINGLudwigshafen am Rhein, 67071, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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BG Universitätsklinikum Bergmannsheil Bochum
RECRUITINGBochum, 44789, Germany
Contact Email: •••••@•••••
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Brussels University Hospital
RECRUITINGBrussels, Jette, 1090, Belgium
Contact
Contact
Contact
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Caritas Krankenhaus St. Josef/ Uniklinik Regensburg
RECRUITINGRegensburg, 93053, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Centre Hospitalier Universitaire Vaudois
RECRUITINGLausanne, Lausanne, 1011, Switzerland
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Department of Plastic and Reconstructive Surgery Uppsala University Hospital
RECRUITINGUppsala, 751 85, Sweden
Contact Email: •••••@•••••
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Harvard Medical School
RECRUITINGBoston, Massachusetts, 02115, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Erasto Gaertner
NOT_YET_RECRUITINGParaná, Curitiba, 80730-001, Brazil
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital de la Santa Creu i Sant Pau
RECRUITINGBarcelona, 08025, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hôpitaux Universitaires de Genève
RECRUITINGGeneva, 1205, Switzerland
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Institute of Oncology ''Prof. Dr. Ion Chiricuță'' of Cluj-Napoca
RECRUITINGCluj-Napoca, 400015, Romania
Contact Phone: •••-•••-•••• Email: •••••@•••••
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KEM Evang. Kliniken Essen-Mitte
RECRUITINGEssen, 45136, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Kantonsspital Aarau
RECRUITINGAarau, 5001, Switzerland
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Kantonsspital Winterthur
RECRUITINGWinterthur, 8401, Switzerland
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Kaohsiung Chang Gung Memorial Hospital
NOT_YET_RECRUITINGKaohsiung City, Taiwan, 833, Taiwan
Contact
Contact
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Karolinska Institutet, K1 Molekylär medicin och kirurgi
RECRUITINGStockholm, 17176, Sweden
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Klinik für Plastische, Rekonstruktive, Aesthetische und Handchirurgie
RECRUITINGZurich, 8091, Switzerland
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Klinikum Nürnberg
RECRUITINGNuremberg, 90419, Germany
Contact Email: •••••@•••••
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Krankenhaus Göttlicher Heiland GmbH
NOT_YET_RECRUITINGVienna, State of Vienna, A-1170, Austria
Contact
Contact
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Maastricht University Medical Center
RECRUITINGMaastricht, 6202, Netherlands
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Mayo Clinic
NOT_YET_RECRUITINGRochester, New York, 55905, United States
Contact
Contact
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McGill University, Royal Victoria Hospital
RECRUITINGMontreal, QC H4A 3J1, Canada
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Papageorgiou Hospital of Thessaloniki
RECRUITINGThessaloniki, 55133, Greece
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Policlinico Tor Vergata: Fondazione PTV
RECRUITINGRome, 00133, Italy
Contact Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Policlinico Universitario Fondazione Agostino Gemelli
RECRUITINGRome, 00168, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Rambam Health Clinic, ISR
NOT_YET_RECRUITINGHaifa, 3109601, Israel
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Sana Kliniken Düsseldorf
RECRUITINGDüsseldorf, 40593, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Uniklinikum Erlangen
RECRUITINGErlangen, 91054, Germany
Contact Email: •••••@•••••
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University Clinics St.Pölten
NOT_YET_RECRUITINGSankt Pölten, Lower Austria, Austria
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University Hospital Basel
RECRUITINGBasel, Basel, 4031, Switzerland
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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University of British Columbia, Gordon and Leslie Diamond Health Care Centre
RECRUITINGVancouver, BC V5Z 1M9, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Ghent
RECRUITINGGhent, 9000, Belgium
Contact Email: •••••@•••••
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Universitätsklinikum Freiburg, Klinik für Plastische und Handchirurgie
RECRUITINGFreiburg im Breisgau, 79106, Germany
Contact Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Washington University School of Medicine in St. Louis
RECRUITINGSt Louis, Missouri, 63110, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Yale School of Medicine
NOT_YET_RECRUITINGNew Haven, Connecticut, 06510, United States
Contact
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
microsurgery (lymphovenous anastomosis and vascularised lymph node transfer)
What this could lead to
If it works, this could offer a surgical option that improves daily life and reduces swelling for people with chronic lymphedema after breast cancer.
What could go wrong
This is a relatively early-stage trial with 280 participants, and surgery carries risks like infection or failure. The benefit over standard care is not yet proven.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.