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Can microsurgery beat standard therapy for Post-Cancer lymphedema?

NCT ID NCT05890677

Disease control Sponsor: University Hospital, Basel, Switzerland Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two microsurgical techniques (LVA and VLNT) against standard conservative therapy for chronic arm swelling after breast cancer treatment. Researchers will measure quality of life in 280 participants one year after surgery. The goal is to see if surgery provides better relief than compression and physical therapy alone.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
microsurgical procedures (lymphovenous anastomosis and vascularised lymph node transfer)
What this could lead to
If successful, this could show that microsurgery offers better quality of life for people with chronic lymphedema after breast cancer, potentially becoming a standard treatment option.
What could go wrong
This is a relatively early-stage trial with 280 participants, and surgery carries risks like infection or failure. Results may not apply to all patients, and the benefit over conservative care is not yet proven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 280 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2023

Expected to finish

Jun 2036

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Written informed consent. * Patients ≥ 18 years of age. * Former diagnosis of breast cancer. * Clinical diagnosis of chronic Breast Cancer-Related Lymphedema (BCRL) (persisting for more than 3 months) classified as ≥ Stage 1, according to ISL. * Minimum of 3 months Conservative Complex Physical Decongestion Therapy. * Ability to complete the QoL questionnaires. * Willingness to undergo surgery. Exclusion Criteria: * No indication for lymphatic surgery according to clinical judgment of the treating surgeon (individual reasons will be specifically documented). * Primary congenital Lymphedema or non-BCRL. * Previous surgical BCRL treatment on the side intended for intervention.

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Conditions

The condition(s) this trial relates to.

Breast Cancer Lymphedema lymphedema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Lymphedema, breast cancer

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    36 sites in 15 countries. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • BG Klinik Frankfurt am Main

    RECRUITING

    Frankfurt, 60389, Germany

  • BG Klinik Ludwigshafen

    RECRUITING

    Ludwigshafen am Rhein, 67071, Germany

  • BG Universitätsklinikum Bergmannsheil Bochum

    RECRUITING

    Bochum, 44789, Germany

  • Brussels University Hospital

    RECRUITING

    Brussels, Jette, 1090, Belgium

  • Caritas Krankenhaus St. Josef/ Uniklinik Regensburg

    RECRUITING

    Regensburg, 93053, Germany

  • Centre Hospitalier Universitaire Vaudois

    RECRUITING

    Lausanne, Lausanne, 1011, Switzerland

  • Department of Plastic and Reconstructive Surgery Uppsala University Hospital

    RECRUITING

    Uppsala, 751 85, Sweden

  • Harvard Medical School

    RECRUITING

    Boston, Massachusetts, 02115, United States

  • Hospital Erasto Gaertner

    NOT_YET_RECRUITING

    Paraná, Curitiba, 80730-001, Brazil

  • Hospital de la Santa Creu i Sant Pau

    RECRUITING

    Barcelona, 08025, Spain

  • Hôpitaux Universitaires de Genève

    RECRUITING

    Geneva, 1205, Switzerland

  • Institute of Oncology ''Prof. Dr. Ion Chiricuță'' of Cluj-Napoca

    RECRUITING

    Cluj-Napoca, 400015, Romania

  • KEM Evang. Kliniken Essen-Mitte

    RECRUITING

    Essen, 45136, Germany

  • Kantonsspital Aarau

    RECRUITING

    Aarau, 5001, Switzerland

  • Kantonsspital Winterthur

    RECRUITING

    Winterthur, 8401, Switzerland

  • Kaohsiung Chang Gung Memorial Hospital

    NOT_YET_RECRUITING

    Kaohsiung City, Taiwan, 833, Taiwan

  • Karolinska Institutet, K1 Molekylär medicin och kirurgi

    RECRUITING

    Stockholm, 17176, Sweden

  • Klinik für Plastische, Rekonstruktive, Aesthetische und Handchirurgie

    RECRUITING

    Zurich, 8091, Switzerland

  • Klinikum Nürnberg

    RECRUITING

    Nuremberg, 90419, Germany

  • Krankenhaus Göttlicher Heiland GmbH

    NOT_YET_RECRUITING

    Vienna, State of Vienna, A-1170, Austria

  • Maastricht University Medical Center

    RECRUITING

    Maastricht, 6202, Netherlands

  • Mayo Clinic

    NOT_YET_RECRUITING

    Rochester, New York, 55905, United States

  • McGill University, Royal Victoria Hospital

    RECRUITING

    Montreal, QC H4A 3J1, Canada

  • Papageorgiou Hospital of Thessaloniki

    RECRUITING

    Thessaloniki, 55133, Greece

  • Policlinico Tor Vergata: Fondazione PTV

    RECRUITING

    Rome, 00133, Italy

    Contact Email: •••••@•••••

  • Policlinico Universitario Fondazione Agostino Gemelli

    RECRUITING

    Rome, 00168, Italy

  • Rambam Health Clinic, ISR

    NOT_YET_RECRUITING

    Haifa, 3109601, Israel

  • Sana Kliniken Düsseldorf

    RECRUITING

    Düsseldorf, 40593, Germany

  • Uniklinikum Erlangen

    RECRUITING

    Erlangen, 91054, Germany

  • University Clinics St.Pölten

    NOT_YET_RECRUITING

    Sankt Pölten, Lower Austria, Austria

  • University Hospital Basel

    RECRUITING

    Basel, Basel, 4031, Switzerland

  • University of British Columbia, Gordon and Leslie Diamond Health Care Centre

    RECRUITING

    Vancouver, BC V5Z 1M9, Canada

  • University of Ghent

    RECRUITING

    Ghent, 9000, Belgium

  • Universitätsklinikum Freiburg, Klinik für Plastische und Handchirurgie

    RECRUITING

    Freiburg im Breisgau, 79106, Germany

  • Washington University School of Medicine in St. Louis

    RECRUITING

    St Louis, Missouri, 63110, United States

  • Yale School of Medicine

    NOT_YET_RECRUITING

    New Haven, Connecticut, 06510, United States

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Other studies related to the condition(s) this trial covers.