University Hospital, Basel, Switzerland

This study tests whether adding the antibiotic linezolid to standard treatment improves outcomes for people with Staphylococcus aureus bloodstream infections. About 606 hospitalized adults will receive either linezolid or a placebo for five days. The goal is to see if the combina…

This Phase II trial tests whether an implant made from a patient's own nasal cartilage can repair knee damage from patellofemoral osteoarthritis. 75 adults aged 18–65 with moderate knee pain will receive either the cartilage implant or standard platelet-rich plasma injections. Th…

This study tests whether inflating a small balloon in the pylorus (the valve between stomach and small intestine) during minimally invasive esophageal cancer surgery can prevent delayed stomach emptying, a common complication. About 116 patients will be randomly assigned to recei…

This study tests a drug called nintedanib in 20 people who developed a lung condition called bronchiolitis obliterans syndrome after a stem cell transplant. Participants take the drug daily for 12 months alongside their usual medications. The main goal is to see if the drug is sa…

This study looks at whether people with inflammatory or autoimmune diseases can safely stop taking steroids (like prednisone) right away instead of slowly reducing the dose over 4 weeks. The goal is to see if stopping quickly leads to more hospital visits or adrenal crises. About…

This study looks at whether it is safe to temporarily stop taking beta-blockers (a common heart medication) in people undergoing a procedure called transcatheter aortic valve replacement (TAVR) for severe aortic stenosis. About 498 adults who are scheduled for TAVR and have been …

This study tests whether giving extra natural killer (NK) cells from a donor can safely help prevent leukemia or MDS from coming back after a stem cell transplant. About 10 adults with acute myeloid leukemia or myelodysplastic syndromes who don't have a fully matched donor will r…

This study tests whether adding nicardipine (a drug that blocks a cancer resistance protein) to standard chemoembolization (TACE) improves outcomes for people with liver cancer. About 152 adults with untreated liver tumors will be randomly assigned to receive either the standard …

This pilot trial tests a peer-led program called PEGISUS, designed to reduce substance use and promote gender-equitable beliefs among young people aged 16-24 in vocational training programs in Zambia, Zimbabwe, and South Africa. Participants attend eight group sessions and are co…

This study looks at whether low-dose prednisolone can effectively treat liver inflammation (hepatitis) that sometimes occurs as a side effect of immune checkpoint inhibitors in cancer patients. Researchers will enroll 63 adults with grade 2 or 3 immune-related hepatitis and give …

This study tests whether offering a choice of nicotine replacement products (like e-cigarettes, nicotine pouches, or patches) helps people with HIV quit smoking. About 972 smokers from the Swiss HIV Cohort Study will be randomly assigned to receive either standard care or a menu …

This study tests whether placing a stent in the brain right after a stroke helps people recover better than the usual clot-removal methods. It includes 498 adults who had a stroke due to a hardened artery that didn't open with initial treatment. The goal is to see if stenting lea…

This study looks at how two different ways of using dopamine agonists (medicines that shrink prolactinomas) affect the body's ability to handle sugar. About 60 adults with prolactinoma will be randomly assigned to one of two treatment strategies. The main goal is to see which app…

This study tests a new treatment for knee osteoarthritis (patellofemoral type) using a cartilage graft made from the patient's own nasal cells. 150 adults aged 18-70 will receive either this experimental implant or standard care (a cartilage repair procedure or partial knee repla…

This study looks at whether adding a drug called Wilate (a von Willebrand factor concentrate) to standard platelet transfusions can reduce bleeding and the need for more blood products in intensive care patients. About 120 adults who need platelets during or after surgery will be…

This study tests whether using telemedicine (video or phone check-ins) can help doctors better adjust heart failure medications after patients leave the hospital. About 140 adults with heart failure and reduced pumping ability will be split into two groups: one gets usual care, t…

This study tests whether the diabetes drug empagliflozin (Jardiance) can safely raise low sodium levels in people with certain conditions like SIADH, liver failure, or kidney failure. About 172 adults with chronic low sodium will receive either the drug or a placebo for up to 30 …

This study tests a treatment that uses immune cells taken from a patient's own lung tumor. These cells are grown in large numbers and given back to the patient to attack the cancer. The trial includes 30 adults with advanced non-small cell lung cancer that has worsened after stan…

This study compares the standard doctor's pupil exam (using a flashlight) to a precise automated device for diagnosing brain death in 50 adults. The goal is to see if the simple test is just as reliable. If it is, hospitals may not need expensive machines for this critical diagno…

This study compares a new diagnostic test using mannitol infusion to the standard hypertonic saline test for diagnosing the cause of polyuria-polydipsia syndrome (excessive urination and thirst). Researchers will enroll 144 adults to see if the mannitol test is as accurate and mo…

This study tests whether two new measurements, aSID and ChU, can help doctors better diagnose and treat low sodium levels in hospitalized patients taking thiazide diuretics for high blood pressure. Researchers will compare outcomes in 136 patients randomly assigned to either stan…

This study tests whether giving ICU patients 0.5 liters of wheat beer each evening for 6 days can lower their risk of developing delirium, compared to patients who receive water. Delirium is a sudden confused state common in intensive care. The trial will include 380 adults who h…

This study tests two simple methods—drinking less water or taking protein supplements—to prevent low sodium levels after pituitary surgery. Low sodium is a common complication that can cause confusion and other issues. About 282 adults having pituitary surgery will be randomly as…

This study tests whether DMT, a psychedelic drug, can reduce depression symptoms through its biological effects alone, or if the psychedelic experience is necessary. 112 adults with major depression will receive DMT or a placebo, some while sedated with propofol to block the psyc…

This study tests whether LSD can reduce anxiety, pain, and depression in people with advanced or terminal illnesses. Sixty participants will receive either moderate to high doses of LSD or a very low dose as a placebo. The goal is to see if LSD can improve quality of life and eas…

This trial compares two microsurgical techniques (LVA and VLNT) against standard conservative therapy for chronic lymphedema in breast cancer survivors. Researchers want to see if surgery leads to better quality of life one year after treatment. The study plans to enroll 280 adul…

This pilot study will test whether a 7-day integrative oncology retreat called 'Via Shalva' is feasible and helpful for women who have finished primary treatment for breast or gynecologic cancer. The retreat includes personalized consultations, complementary therapies, and group …

This study compares two ways to treat breast cancer that has spread to nearby lymph nodes: targeted radiotherapy or surgical removal of the nodes. The goal is to see which approach better preserves arm function and reduces the risk of long-term arm swelling. About 1,060 adults wi…

This study tests whether using a smaller chest drain (16F) causes less pain after minimally invasive lung surgery compared to the standard larger drain (24F). About 124 adults having lung lobe or segment removal will be randomly assigned to one drain size. Pain levels while cough…

This study tests whether a nasal spray containing oxytocin can help reduce anxiety and improve emotional well-being in adults with central diabetes insipidus, a condition where the body lacks a key hormone. Participants will receive either oxytocin or a placebo spray for several …

This study tests whether an intensive follow-up program can improve bowel control and quality of life for people who have had rectal cancer surgery. About 140 adults who had surgery and a temporary colostomy will be split into two groups: one gets the intensive program with extra…

This study tests whether a nasal spray containing oxytocin (the 'love hormone') can improve sexual well-being in people with central diabetes insipidus, a condition that causes extreme thirst and frequent urination. About 42 participants (patients and healthy volunteers) will rec…

This early-stage study explores whether MDMA (the active ingredient in ecstasy) can reduce pain. Twenty healthy volunteers will receive either MDMA or a placebo, while mild pain is created using small electrical pulses under the skin. Researchers will compare pain ratings between…

This study follows 1000 men with an enlarged prostate who are receiving Rezum water vapor therapy, a minimally invasive steam treatment. The goal is to see how well it relieves urinary symptoms and improves quality of life over 5 years. Researchers will track symptom scores, urin…

This early-phase study tests whether a natural odor, when inhaled, can be detected in the cerebrospinal fluid (CSF) of 32 lean and obese adults. Participants inhale either the odor or a placebo, then a CSF sample is taken within 30 minutes. The goal is simply to see if the odor m…

This study reviews medical records of 600 people with HER2+ or triple-negative breast cancer who had chemotherapy and still had cancer in their lymph nodes. The goal is to see if skipping additional lymph node removal (axillary dissection) leads to more cancer coming back in the …

This early-stage study is testing how safe and tolerable intravenous 5-MeO-DMT is in 40 healthy adults aged 25-65. Participants receive either a low dose of the psychedelic or a placebo, and researchers monitor their heart rate, blood pressure, and subjective experiences. The goa…

This registry will collect health data from 8,000 adults with cardiogenic shock, a life-threatening condition where the heart suddenly can't pump enough blood. Researchers aim to track what treatments are used and how patients fare, including survival rates in the hospital and up…

This study is creating a new tool to measure pain during cesarean delivery. Researchers will review existing research, ask experts for their input, and interview 15 women who recently had a C-section to make sure the tool reflects what patients actually experience. The goal is to…

This pilot study compares how well artificial intelligence (AI) and human sonographers can measure the inferior vena cava (a large vein) using ultrasound to assess hydration status. Fifty healthy adults will have ultrasound scans before and after a fluid challenge, with measureme…

The PREVENT study is a large, worldwide registry that will track 1,000 stroke patients who undergo a clot-removal procedure called thrombectomy. Researchers want to understand why a blood vessel sometimes gets poked during the procedure, causing dangerous bleeding. By studying me…

This study looks at how metabolism in cancer and immune cells influences the bone marrow environment and treatment resistance in blood cancers like leukemia and myelofibrosis. Researchers will analyze samples from 350 participants to measure metabolites, lipids, and gene activity…

This study is testing whether taking estrogen pills (estradiol valerate or ethinylestradiol) can safely trigger the release of oxytocin, a hormone important for social bonding and childbirth. Researchers will measure oxytocin levels in 28 healthy volunteers and patients with AVP …

This study looks at whether keeping a patient's blood pressure within their personal safe range during heart surgery can reduce brain problems like confusion, stroke, or memory issues. Researchers will monitor 500 patients having heart surgery and track their blood pressure and b…

This study tests a tool to better predict which emergency department patients are at risk of dying within 30 days. Researchers will track about 6,500 adults visiting the ER over three separate 9-week periods. The goal is to improve how doctors decide on hospital admission, ICU ca…

This study looks at how physical activity, fitness, stress, and sleep affect pregnancy rates in women receiving fertility treatments like IVF or IUI. Researchers will track 115 women aged 18-43 to see if being more active improves their chances of getting pregnant. The goal is to…

This study looks at how different breathing pressures and lying on your stomach change blood flow in the veins of 40 healthy adults. Researchers use ultrasound to measure vein congestion. The goal is to better understand these effects, not to treat any disease.

This study is gathering information from 1,000 adults who had a prolonged seizure (status epilepticus) to learn how doctors can better predict outcomes and tailor treatments. Researchers will look at medical records, lab results, and monitoring data from two Swiss hospitals. The …

This study tests whether music enhanced with sonic augmentation technology can increase oxytocin (a hormone linked to social bonding) with few side effects. Researchers will compare the modified music to regular music in 22 healthy adults and patients with AVP-deficiency. The goa…

This study is a registry that collects information on adults (18 and older) with congenital heart disease who are treated at specialized Swiss centers. The goal is to learn about long-term complications and the best ways to manage their care. No new treatments are being tested; i…

This study looks at whether trained community health workers can effectively screen and manage chronic diseases like high blood pressure and diabetes in rural Lesotho. About 17,500 adults will take part, with health workers using simple tools and eHealth apps to monitor and refer…

This study looks at whether taking 200mg of caffeine (about two cups of coffee) changes how active your brown fat is when you're mildly cold. Brown fat is a type of body fat that burns energy to generate heat. Researchers will scan 12 healthy adults to measure brown fat activity …

This study looks at whether slowly increasing the dose of the sleep medicine propofol based on each person's needs can keep blood pressure more stable than a standard starting dose. It involves 320 adults aged 55 and older having planned non-heart surgery. The goal is to find a s…

This study looks at how the immune system helps the body accept a pregnancy during the first three months. Researchers will analyze blood samples from 100 women undergoing IVF to understand which immune cells and genes are linked to healthy pregnancies or miscarriages. The goal i…

This study looks at whether fluid buildup in veins (congestion) affects blood flow in the smallest blood vessels after planned heart surgery. Researchers will monitor 40 adults in the ICU using ultrasound and other tools. The goal is to better understand these connections, not to…

This study tests a new MRI method called AMIRA to better detect spinal cord lesions in people with multiple sclerosis (MS). Ten adults with MS will get both standard and new MRI scans. The goal is to see if the new method finds more lesions and helps doctors agree on what they se…

This study looks at people who have had repeated, mild episodes of diverticulitis (inflammation of pouches in the colon). It compares those who have surgery to remove the affected part of the colon with those who manage the condition without surgery. The goal is to see which appr…

This study uses whole genome sequencing to track how ESBL-producing bacteria (a type of drug-resistant germ) spread among hospital patients and staff. Researchers will analyze samples from 2,000 people to find out where infections come from and how they move. The goal is to bette…

This study reviews medical records of 1,000 patients who came to the hospital with sudden neurological symptoms like weakness, speech problems, or seizures. The goal is to find out how many are diagnosed with Functional Neurological Disorder (FND), a condition where the brain doe…

This study aims to better understand multiple sclerosis (MS) by using artificial intelligence and digital health tools. Researchers will follow 100 adults with MS, collecting medical images, blood samples, and smartphone data to find patterns that predict disease progression. No …

This study is looking at whether tiny bits of tumor DNA (ctDNA) found in blood or urine can help doctors better understand and predict the course of a high-risk type of bladder cancer called T1G3. About 35 adults with this cancer will provide samples before, during, and after tre…

This study follows 600 transgender and gender-diverse people in Switzerland to learn what affects their health and happiness during gender-affirming treatments. Participants fill out surveys, give blood and other samples, and have routine check-ups. The goal is to find out which …

This study looks at a new compound called DDH-LSD, which is similar to LSD but is expected to wear off faster. Researchers will give 24 healthy adults DDH-LSD, LSD, or a placebo in random order to compare how long each lasts, how the body processes them, and what effects people f…

This study is tracking how breast surgery affects patients' quality of life and satisfaction. Researchers will survey 1000 adults who had any type of breast surgery at the University Hospital of Basel. The goal is to better understand the surgery's impact, not to test a new treat…