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Coffee vs. cold: can your morning cup fire up brown fat?

NCT ID NCT06978777

Knowledge-focused Sponsor: University Hospital, Basel, Switzerland Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This study looks at whether taking 200mg of caffeine (about two cups of coffee) changes how active your brown fat is when you're mildly cold. Brown fat is a type of body fat that burns energy to generate heat. Researchers will scan 12 healthy adults to measure brown fat activity after caffeine or a placebo. The goal is to better understand how caffeine might influence metabolism.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

12 people

The number who actually took part.

Started

Jan 2026

Finished

May 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * BMI 18.5 to 25 kg/m2 * Able to give informed consent as documented by signature * Moderate caffeine consumption (1 to 3 cups of coffee per day) * Increase of EE in response to mild cold of ≥ 5% of REE Exclusion Criteria: * Known hypersensitivity or allergy to caffeine * Concomitant medication other than prescription free analgesics (paracetamol and NSAID) and oral contraceptives * Other clinically significant concomitant disease states (e.g., renal failure, hepatic dysfunction, cardiovascular disease, cardiac arrhythmia, hypertension, diabetes mellitus, hyper- or hypothyroidism) * History of depressive disorder or anxiety disorder * Smoker / habitual tobacco use * Habitual excessive alcohol use * Regular consumption of caffeine containing energy drinks * Weight change of \>5% within 3 months prior to inclusion * Systolic blood pressure \>140 mmHg and/or diastolic blood pressure \> 95 mmHg. * Resting heart rate \>90 bpm * Hypersensitivity to cold (e.g. Raynaud syndrome) * Known or suspected non-compliance, drug or alcohol abuse * Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant. * Enrolment of the investigator, his/her family members, employees, and other dependent persons * Enrolment into another study using ionizing radiation within the previous 12 months. * Pregnancy or lactation

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Brown adipose tissue (BAT) physiology Cold exposure

Contacts and locations

Locations

  • University Hospital Basel, Department of Endocrinology

    Basel, 4031, Switzerland

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