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Chill out to burn fat? scientists probe brown Fat's secrets

NCT ID NCT07048405

Knowledge-focused Sponsor: University of Edinburgh Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 01, 2026 · Updated 2 times

Summary

This study looks at how repeated short-term cold exposure affects brown adipose tissue (brown fat), a type of body fat that burns energy to generate heat. Twelve healthy adults will undergo a 10-day cold acclimation protocol using cooling blankets. Researchers will take tissue samples and use PET/CT scans to measure changes in brown fat activity and gene expression, aiming to better understand its role in metabolism.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could reveal how cold exposure improves metabolism, potentially pointing toward new ways to manage weight or metabolic health.
What could go wrong
This is a very small, early-stage study (12 people) focused on understanding basic biology, not testing a treatment. Results may not apply to the general population.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 12 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2025

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged 18-40 years * Body mass index 18.5-25 kg/m2 * Weight change of less than 5% in the past 6 months * No acute or chronic medical conditions * On no regular medications (other than contraceptives in female participants) * No claustrophobia * Alcohol intake ≤14 units/ week * Screening blood tests within acceptable limits (of no clinical significance) * Not currently pregnant, lactating or breastfeeding (female participants only) * Ability to provide informed consent. Exclusion Criteria: * Not meeting inclusion criteria * Contra-indication to PET/CT scan * Allergy to local anaesthetic

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

18F-FDG pet/CT Brown adipose tissue Cold exposure

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Royal Infirmary of Edinburgh

    RECRUITING

    Edinburgh, United Kingdom

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