University Hospital, Basel, Switzerland

This phase III trial tests whether a less extensive lymph node surgery (tailored axillary surgery) followed by radiotherapy works as well as the standard full lymph node removal in women with breast cancer that has spread to the lymph nodes. The study involves 1,500 participants …

This pilot study explores how a 6-month low-carbohydrate diet affects blood sugar control, body composition, and gut-brain interactions in 40 obese adults with or without glucose intolerance or diabetes. Participants follow a low-carb eating plan, and researchers measure changes …

This trial tests whether trained village health workers, supported by a smartphone app, can effectively manage type 2 diabetes in rural Lesotho. 252 adults with diabetes will either receive community-based care (including medication and lifestyle advice) or be referred to a clini…

This early-phase trial tests a new treatment for people with advanced melanoma that cannot be removed by surgery or has spread. The therapy uses a patient's own immune cells (tumor-infiltrating lymphocytes) grown in a lab and then given back along with a drug called ANV419 to hel…

This study tests whether trained village health workers, supported by an eHealth app, can effectively manage high blood pressure in rural Lesotho. About 1,350 adults with either uncontrolled or controlled hypertension will receive either community-based care from these workers or…

This early-phase study tests a radioactive drug (177Lu-PP-F11N) that seeks out and attaches to cancer cells in people with advanced medullary thyroid cancer and certain other neuroendocrine tumors. The goal is to see if the drug can help image tumors and deliver targeted radiatio…

This study looks at whether liquid biopsies—simple blood tests that detect tumor DNA—can be used during regular doctor visits for people with advanced solid tumors. Researchers will collect blood samples from 159 patients and measure ctDNA levels to see how often the test finds t…

This study compares two ways of using blood tests to diagnose heart attacks in people arriving at the emergency room with chest pain. The standard approach measures a heart-damage marker in the blood at arrival and again 3 hours later. The newer approach does the second test afte…

This study compares a new, non-invasive PET-MRI scan to the standard invasive test (IPSS) for finding pituitary tumors in people with Cushing's disease. About 43 adults with confirmed Cushing's will get both tests to see which is more accurate. The goal is to make diagnosis safer…

This study planned to test whether two drugs, empagliflozin and anakinra, could help people with prediabetes who experience low blood sugar after meals. The trial was withdrawn before enrolling any participants, so no results are available. It was designed for adults with prediab…

This study looks at whether a new screening system can help doctors find heart complications early in high-risk patients after noncardiac surgery. Researchers will track 900 patients to see how well the screening works in practice and what it costs. The goal is to gather informat…

This pilot study compares the effects of daily erythritol (a sugar substitute) versus regular sugar on insulin resistance and blood clotting in 30 healthy adolescents aged 14-18. Participants consume either erythritol or sucrose for 5 weeks, and researchers measure changes in glu…

This study looks back at the medical records of 2,000 adults who were physically restrained in a Swiss intensive care unit between 2010 and 2023. The goal is to understand how often restraints are used, what problems they cause, and which patients are more likely to be restrained…

This study reviewed the medical records of 532 adults who had a palliative care consult before, during, or after an ICU stay at a Swiss hospital between 2019 and 2024. Researchers looked at what led to the consult, how long patients stayed in the hospital, and what happened to th…

This study looks at why some people have Long COVID symptoms like fatigue and brain fog. It also tests if a 12-week smartphone app with breathing exercises, relaxation, and energy management can help. About 120 adults with Long COVID are taking part to share health data and try t…

This study looks at whether low blood pressure during major non-cardiac surgery can harm organs like the heart and kidneys. Researchers used a special brain monitor to find each patient's safe blood pressure range. The goal is to see if staying within that range can reduce compli…

This study surveys 530 prolactinoma patients and their doctors to understand real-world treatment experiences, side effects, and preferences. The goal is to identify gaps in care and guide future research for better, more personalized treatment strategies. No new treatments are t…

This study follows nearly 20,000 patients who had major non-cardiac surgery to learn about heart injuries that can happen during or after the procedure. Researchers track how common these injuries are, what patient factors are involved, and how they affect survival and heart heal…

This study looks at how changing the length of the small intestine during gastric bypass surgery affects metabolism and inflammation in people with severe obesity. Researchers will compare 50 patients who had the surgery with 15 healthy volunteers. The goal is to understand the b…

This study looks at how three common sugars—sucrose, glucose, and fructose—affect the body in healthy, normal-weight adults. Researchers will measure changes in gut hormones, blood sugar, blood clotting, and how fast the stomach empties. The goal is to better understand the body'…

This study tests whether a new monitoring method can track brain blood flow in real time during major noncardiac surgery. Researchers will enroll 256 adults to see if the Medtronic Cotrending algorithm works reliably. The goal is to learn if this tool can help doctors keep the br…