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Could less surgery be just as effective for breast cancer patients?

NCT ID NCT03513614

Ongoing Disease control Sponsor: University Hospital, Basel, Switzerland Source: ClinicalTrials.gov ↗

First seen May 02, 2026 · Last updated Jun 22, 2026 · Updated 9 times

Summary

This phase III trial tests whether a less extensive lymph node surgery (tailored axillary surgery) followed by radiotherapy works as well as the standard full lymph node removal in women with breast cancer that has spread to the lymph nodes. The study involves 1,500 participants and aims to see if the gentler approach can reduce side effects like arm swelling without increasing the risk of cancer coming back. Results are not yet available.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Alexandra General Hospital

    Athens, 115 28, Greece

  • Athens Medical Center Iatriko

    Marousi, 151 25, Greece

  • Attikon University Hospital

    Chaïdári, Athens, 124 62, Greece

  • Bacs-Kiskun Country Hospital

    Kecskemét, 6000, Hungary

  • Bethesda Spital Basel, Gynäkologie und Geburtshilfe

    Basel, 4052, Switzerland

  • Breast Centre of Clinical Hospital

    Rijeka, 51000, Croatia

  • Breast center Fribourg

    Fribourg, 1700, Switzerland

  • Brust-Zentrum Zürich (Seefeld)

    Zurich, 8008, Switzerland

  • Brustzentrum Basel und Netzwerk

    Allschwil, 4123, Switzerland

  • Brustzentrum Bern, Lindenhofgruppe Centerclinic

    Bern, 3011, Switzerland

  • Brustzentrum Thurgau

    Frauenfeld, 8501, Switzerland

  • CIUSSS du Centre Ouest-de-l'Île-de-Montréal, Jewish General Hospital

    Montreal, 3755, Canada

  • Centre Hospitalier Universitaire Vaudois CHUV

    Lausanne, 1011, Switzerland

  • Centro di Senologia della Svizzera Italiana CSSI

    Lugano, 6970, Switzerland

  • Clinique de Genolier

    Genolier, 1272, Switzerland

  • Clinique de Grangettes

    Chêne-Bougeries, 1224, Switzerland

  • Duke University/Duke Cancer Center

    Durham, North Carolina, 27710, United States

  • Fondazione Policlinico Universitario "Agostino Gemelli" di Roma

    Rome, 00168, Italy

  • Gangnam Severance Hospital

    Seoul, 06273, South Korea

  • HRUHC Sestre milosdrnice

    Zagreb, Croatia

  • HUG - Hôpitaux Universitaires de Genève

    Geneva, 1205, Switzerland

  • Hanusch Hospital Vienna

    Vienna, 1140, Austria

  • Helios University Hospital Wuppertal

    Wuppertal, 42283, Germany

  • Hirslanden Klinik St. Anna

    Lucerne, 6006, Switzerland

  • Hôpital Neuchâtelois

    La Chaux-de-Fonds, 2300, Switzerland

  • Hôpital du Valais / Hôpital de Sion

    Sion, 1950, Switzerland

  • Iaso Maternity Hospital

    Marousi, 151 23, Greece

  • Institute of Oncology "Angel H. Roffo

    Buenos Aires, C1417, Argentina

  • KEM | Evang. Kliniken Essen-Mitte gGmbH

    Essen, 45136, Germany

  • Kantonsspital Aarau

    Aarau, 5001, Switzerland

  • Kantonsspital Baden

    Baden, 5404, Switzerland

  • Kantonsspital Graubünden

    Chur, 7000, Switzerland

  • Kantonsspital St. Gallen

    Sankt Gallen, 9000, Switzerland

  • Kantonsspital Winterthur, Brustzentrum

    Winterthur, 8401, Switzerland

  • Klinikum Wels-Grieskrichen GmbH

    Wels, 4600, Austria

  • Krankenhaus Dornbirn

    Dornbirn, 6850, Austria

  • Landeskrankenhaus Feldkirch

    Feldkirch, 6800, Austria

  • Larissa General University Hospital

    Larissa, 413 34, Greece

  • Luzerner Kantonsspital - Brustzentrum

    Lucerne, 6000, Switzerland

  • Medical University of Innsbruck, Department of Gynecology

    Innsbruck, 6020, Austria

  • Medizinische Universität Wien - Klinik für Chirurgie

    Vienna, 1090, Austria

  • Medizinische Universität Wien - Universitätsklinik für Frauenheilkunde

    Vienna, 1090, Austria

  • National Cancer Institut

    Vilnius, 08406, Lithuania

  • National Institute of Oncology

    Budapest, 1122, Hungary

  • Niels-Stensen-Kliniken Franziskus-Hospital Harderberg

    Georgsmarienhütte, 49124, Germany

  • Ordens Kinikum Linz, Barmherzige Schwestern

    Linz, 4010, Austria

  • Ospedale MultiMedica Castellanza

    Castellanza, 21053, Italy

  • Pauls Stradinš Clinical University Hospital

    Riga, 1002, Latvia

  • Samsung Medical Center

    Seoul, 06351, South Korea

  • Sanatorio Parque Breast Cancer Center

    Rosario, Santa Fe Province, S2000, Argentina

  • Spital Limmattal

    Schlieren, 8952, Switzerland

  • Spital Zollikerberg

    Zollikerberg, 8125, Switzerland

  • Stadtspital Triemli

    Zurich, 8063, Switzerland

  • Swedish Cancer Institute

    Seattle, Washington, 98104, United States

  • Tumor-and Breast centre Ostschweiz

    Sankt Gallen, 9016, Switzerland

  • University Hospital of Heraklion

    Heraklion, Crete, 71500, Greece

  • University Hospital of Patras

    Pátrai, 265 04, Greece

  • University of Szeged

    Szeged, 6720, Hungary

  • Universitäts Spital Zürich

    Zurich, 8091, Switzerland

  • Universitätsklinik für Frauenheilkunde und Geburtshilfe; Landeskrankenhaus Salzburg der PMU

    Salzburg, 5020, Austria

  • Universitätsklinikum Heidelberg, Sektion Senologie

    Heidelberg, 69120, Germany

  • Universitätsspital Basel

    Basel, 4031, Switzerland

  • ViDia Christliche Kliniken Karlsruhe, Diakonissenkrankenhaus

    Karlsruhe, 76199, Germany

  • Walter Reed National Military Medical Center

    Bethesda, Maryland, 20814, United States

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

tailored axillary surgery and radiotherapy

What this could lead to

If successful, this approach could spare many women with breast cancer from the side effects of full lymph node removal, such as arm swelling and pain, while keeping the same cancer control.

What could go wrong

This is a large phase III trial, but results are not yet available. There is a risk that the less extensive surgery may not control the cancer as well as the standard approach, leading to higher recurrence rates.

Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NODE-POSITIVE BREAST CANCER