Psychedelic 5-MeO-DMT infused in healthy brains: first safety trial begins
NCT ID NCT07444788
First seen Mar 06, 2026 · Last updated Jun 23, 2026 · Updated 15 times
Summary
This early-stage study is testing how safe and tolerable intravenous 5-MeO-DMT is in 40 healthy adults aged 25-65. Participants receive either a low dose of the psychedelic or a placebo, and researchers monitor their heart rate, blood pressure, and subjective experiences. The goal is to understand the drug's effects and safety before any potential therapeutic use.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University Hospital Basel
RECRUITINGBasel, Canton of Basel-City, 4056, Switzerland
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
5-MeO-DMT (a psychedelic compound)
What this could lead to
If successful, this study could provide safety data to support future trials of 5-MeO-DMT for conditions like depression or anxiety.
What could go wrong
This is an early Phase 1 safety study in healthy people, not designed to test any disease treatment. The compound may cause intense psychological effects or side effects.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.