The University Of Texas Health Science Center At San Antonio

This study tests whether the drug rapamycin is safe and tolerable for older adults with mild cognitive impairment or early Alzheimer's disease. Over 12 months, 40 participants will take oral rapamycin to see how it affects their health and thinking. The goal is to gather initial …

This study compares two different drug combinations for people recently diagnosed with type 2 diabetes. One group gets pioglitazone plus tirzepatide, the other gets metformin plus sitagliptin. The goal is to see which combo better lowers blood sugar and keeps it under control ove…

This study tests a combination of two experimental drugs, bemcentinib and pacritinib, in people with advanced lung adenocarcinoma that has not responded to standard treatments. The goal is to see if the combination can shrink tumors or slow cancer growth. About 44 participants wi…

This study is testing a combination of two immunotherapy drugs, tremelimumab and durvalumab, in people with advanced liver cancer who also have moderate cirrhosis (Child-Pugh B). The goal is to see if this treatment is safe and tolerable in this group, who are often excluded from…

This study tests a drug called sacituzumab govitecan in people whose glioblastoma (a fast-growing brain tumor) has come back after standard treatment. The drug targets a protein called Trop-2 found on tumor cells. Researchers want to see if it helps patients live longer compared …

This study tests two FDA-approved materials used to preserve jawbone after a tooth is pulled. One is a synthetic calcium apatite in a collagen sponge, the other is a human donor bone graft. About 44 adults needing a single tooth extraction and later a dental implant will join. Re…

This study tests if dupilumab can reduce allergic reactions in adults with asthma triggered by house dust mites. Participants will be exposed to dust mites in a special chamber and receive either dupilumab or a placebo. The goal is to see how the drug changes gene activity in the…

This study tests a new treatment called IR-TMS, which uses magnetic fields to target specific brain areas, to see if it can help people with alcohol use disorder drink less. About 150 participants will receive a few sessions of this brain stimulation, along with brain scans and b…

This early-stage study tests whether adding the drug avasopasem to standard hormone therapy and a CDK 4/6 inhibitor is safe and can help control metastatic hormone receptor positive breast cancer. About 35 women whose cancer has worsened on current treatments will participate. Th…

This study tests whether a non-invasive device that sends a mild electrical current to the brain can improve mood, reduce apathy, and ease anxiety in people with Alzheimer's disease. Participants use the device at home for 30-minute sessions. The goal is to see if this safe, drug…

This study tests whether using a microscope during gum surgery helps the gums heal better than using standard magnifying glasses (dental loupes). About 25 adults with gum disease will take part. The main goal is to see if the microscope leads to faster and better wound healing.

This study compares two antipsychotic medications, pimavanserin and quetiapine, to see which one works better for reducing hallucinations and delusions in people with Parkinson's disease or dementia with Lewy bodies. About 94 participants will be randomly assigned to one of the t…

This early study tests a medicated mist (tranexamic acid) sprayed into the mouth to stop bleeding after tonsil removal in children. The goal is to see if the mist can control bleeding without needing another surgery or blood transfusion. About 12 children aged 2 to 17 who have bl…

This study tests whether high-intensity exercise before virtual reality therapy can improve balance and brain flexibility in people with Parkinson's disease. Sixteen participants will be split into two groups: one does intense exercise plus VR, the other does stretching plus VR, …

This study tests whether taking amino acid supplements during dialysis can help reduce fatigue, frailty, and improve thinking in people with end-stage kidney disease. About 28 adults on dialysis will take either a single amino acid (valine) or a mix of essential amino acids. The …

This study looks at whether using the Calm meditation app for 10 minutes a day can help people with blood cancer who have trouble sleeping. About 276 patients will be randomly assigned to one of two app-based wellness programs for 8 weeks, then followed for another 12 weeks. The …

This study aims to improve how clinical trials for dementia and Alzheimer's are conducted. Researchers will test if a new way of measuring thinking and daily function (called "δ") can better show if a treatment works. They will also check if blood proteins called adipokines can p…

This study looks at how the hormone glucagon influences blood sugar in people who have had bariatric surgery and those who haven't. Researchers will use an investigational drug called REMD-477 to block glucagon and measure changes in glucose metabolism. The goal is to better unde…

This study looks at whether a special 3D X-ray (CBCT) can help dentists know when it's safe to place a dental implant after sinus surgery. About 25 adults who need a sinus lift for an implant will get a 3D scan right after surgery and again 6 months later. Researchers will compar…

This small early study is testing whether a drink containing ketone esters can improve how the heart works in people who have both type 2 diabetes and heart failure with reduced pumping ability. Ten adults will take the drink once and then daily for a week while researchers measu…

This study looks at how gastric bypass surgery changes the way the body controls insulin and blood sugar. Some people develop life-threatening low blood sugar years after surgery, while others see their diabetes improve. Researchers want to understand the role of gut hormones and…

This study looks at whether low-frequency ultrasound baths can improve muscle strength, thinking skills, and immune health in healthy adults aged 70 and older. Twenty participants will either receive ultrasound baths or plain baths three times a week for eight weeks. The goal is …

This study is creating a 'living biobank' of miniature tumor models (organoids) from lung cancer patients. Researchers will test how these organoids respond to chemotherapy and targeted drugs, and compare results to what happens in the patient. The goal is to better understand tr…

This study looks at how mitochondria (the energy factories in cells) work in the liver of people who have both type 2 diabetes and nonalcoholic fatty liver disease. Researchers will measure liver energy use before and after 16 weeks of treatment with the diabetes drug pioglitazon…

This study looks at how tirzepatide, a weight-loss drug, affects muscle mass and strength in adults aged 50 and older with obesity. Researchers want to know if losing weight with this drug also causes harmful muscle loss that could lead to weakness or frailty. Twenty participants…

This early-phase study looks at how a common diabetes drug (SGLT2 inhibitor) changes the way the heart and muscles use ketones for energy. Researchers will measure energy levels, exercise capacity, and walking distance in 30 adults with type 2 diabetes and heart failure. The goal…

This study looks at how two types of weight-loss surgery—gastric bypass and sleeve gastrectomy—change the way the body handles sugar after a meal. Researchers will measure insulin levels in 200 people, including those who had surgery and healthy volunteers. The goal is to underst…

This study looks at how giving DHA and ARA (types of healthy fats) to very premature babies (born at 25-29 weeks) affects their body's fat processing and development. Researchers will measure changes in blood fats and related markers to understand how these supplements influence …

This study aims to understand how gastric bypass surgery improves blood sugar control and leads to weight loss. Researchers will measure gut hormones and insulin responses in 80 adults, including those who had surgery and healthy volunteers. The goal is to learn more about the bo…

This study looks at the genes of people with rare nervous system tumors called pheochromocytoma and paraganglioma. Researchers want to find the genetic causes and link them to specific symptoms. Up to 2,000 participants, including patients and their family members, will provide D…

This study looks at how a common diabetes medication (SGLT2 inhibitor) changes energy use in the heart and muscles of people with type 2 diabetes and heart failure. Researchers will measure key energy molecules and walking ability in 71 adults aged 18-80. The goal is to understan…